https://m2.mtmt.hu/ hun 2026-05-30 23:10 JournalArticle 31203017 VALIDATED true * Megosztott szerzőség 0 false 2026-05-22T10:05:29.513+0000 2026-04-16T07:24:31.896+0000 2020-03-02T18:45:14.597+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-04-16T07:24:32.295+0000 2026-04-16T07:24:32.295+0000 2023-09-02T15:34:18.177+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10073918 /api/admin/10073918 Kovács Marcell true true 2024-09-09T07:21:55.189+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Brenner, Gábor B Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion true true /api/journal/10051562 REVIEWED true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 9 3 551 551 17 2020 Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of 'hidden cardiotoxicity' is defined as cardiotoxicity of a drug that manifests in the diseased (e.g. ischemic/reperfused), but not in the healthy heart or as a drug-induced deterioration of cardiac stress adaptation (e.g. ischemic conditioning). Here, we aimed to test if the cardiotoxicity of a selective COX-2 inhibitor rofecoxib that was revealed during its clinical use, i.e., increased occurrence of proarrhythmic and thrombotic events, could have been revealed in early phases of drug development by using preclinical models of ischemia/reperfusion (I/R) injury. Rats that were treated with rofecoxib or vehicle for four weeks were subjected to 30 min. coronary artery occlusion and 120 min. reperfusion with or without cardioprotection that is induced by ischemic preconditioning (IPC). Rofecoxib increased overall the arrhythmias including ventricular fibrillation (VF) during I/R. The proarrhythmic effect of rofecoxib during I/R was not observed in the IPC group. Rofecoxib prolonged the action potential duration (APD) in isolated papillary muscles, which was not seen in the simulated IPC group. Interestingly, while showing hidden cardiotoxicity manifested as a proarrhythmic effect during I/R, rofecoxib decreased the infarct size and increased the survival of adult rat cardiac myocytes that were subjected to simulated I/R injury. This is the first demonstration that rofecoxib increased acute mortality due to its proarrhythmic effect via increased APD during I/R. Rofecoxib did not interfere with the cardiprotective effect of IPC; moreover, IPC was able to protect against rofecoxib-induced hidden cardiotoxicity. These results show that cardiac safety testing with simple preclinical models of I/R injury uncovers hidden cardiotoxicity of rofecoxib and might reveal the hidden cardiotoxicity of other drugs. 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Classification 12125 /api/classification/12125 true true Classification 12226 /api/classification/12226 true true Classification 12184 /api/classification/12184 true true Classification 12207 /api/classification/12207 true true Keyword 1882 /api/keyword/1882 true 1882 true Keyword 3511 /api/keyword/3511 true 3511 true Keyword 14008 /api/keyword/14008 true 14008 true Keyword 15030 /api/keyword/15030 true 15030 true Keyword 17893 /api/keyword/17893 true 17893 true Keyword 1311845 /api/keyword/1311845 true 1311845 true Keyword 1560811 /api/keyword/1560811 true true Keyword 1724784 /api/keyword/1724784 true true Keyword 1974252 /api/keyword/1974252 true true Keyword 1974253 /api/keyword/1974253 true true SjrRating 10991447 /api/sjrrating/10991447 398 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 DIRECT true true /api/publication/31203017 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10052112"><a href="/gui2/?type=authors&mode=browse&sel=10052112" target="_blank">Brenner Gábor B (<span class="authorship-author-name">Brenner Gábor</span> <span class="authorAux-mtmt"> Kardiovaszkuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055074"><a href="/gui2/?type=authors&mode=browse&sel=10055074" target="_blank">Makkos András (<span class="authorship-author-name">Makkos András</span> <span class="authorAux-mtmt"> orvos</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051812"><a href="/gui2/?type=authors&mode=browse&sel=10051812" target="_blank">Nagy Csilla Terézia (<span class="authorship-author-name">Nagy Csilla Terézia</span> <span class="authorAux-mtmt"> kardiovaszkuláris megbetegedések</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061054"><a href="/gui2/?type=authors&mode=browse&sel=10061054" target="_blank">Onódi Zsófia (<span class="authorship-author-name">Onódi Zsófia</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074459"><a href="/gui2/?type=authors&mode=browse&sel=10074459" target="_blank">Sayour Nabil V (<span class="authorship-author-name">Sayour Viktor Nabil</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074629"><a href="/gui2/?type=authors&mode=browse&sel=10074629" target="_blank">Gergely Tamás G (<span class="authorship-author-name">Gergely Tamás G</span> <span class="authorAux-mtmt"> kardiovaszkuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064374"><a href="/gui2/?type=authors&mode=browse&sel=10064374" target="_blank">Kiss Bernadett (<span class="authorship-author-name">Kiss Bernadett</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027602"><a href="/gui2/?type=authors&mode=browse&sel=10027602" target="_blank">Görbe Anikó (<span class="authorship-author-name">Görbe Anikó</span> <span class="authorAux-mtmt"> orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037547"><a href="/gui2/?type=authors&mode=browse&sel=10037547" target="_blank">Sághy Éva (<span class="authorship-author-name">Sághy Éva</span> <span class="authorAux-mtmt"> Gyógyszertudományok, farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017488"><a href="/gui2/?type=authors&mode=browse&sel=10017488" target="_blank">Zádori Zoltán S (<span class="authorship-author-name">Zádori Zoltán Sándor</span> <span class="authorAux-mtmt"> Farmakológia, gasztrointesztinális farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057402"><a href="/gui2/?type=authors&mode=browse&sel=10057402" target="_blank">Lázár Bernadette (<span class="authorship-author-name">Lázár Bernadette</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040912"><a href="/gui2/?type=authors&mode=browse&sel=10040912" target="_blank">Baranyai Tamás (<span class="authorship-author-name">Baranyai Tamás</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047823"><a href="/gui2/?type=authors&mode=browse&sel=10047823" target="_blank">Varga Richárd S (<span class="authorship-author-name">Varga Richárd Sándor</span> <span class="authorAux-mtmt"> Kísérletes szív-elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027733"><a href="/gui2/?type=authors&mode=browse&sel=10027733" target="_blank">Husti Zoltán (<span class="authorship-author-name">Husti Zoltán</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001232"><a href="/gui2/?type=authors&mode=browse&sel=10001232" target="_blank">Varró András (<span class="authorship-author-name">Varró András</span> <span class="authorAux-mtmt"> Szívelektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015597"><a href="/gui2/?type=authors&mode=browse&sel=10015597" target="_blank">Tóthfalusi László (<span class="authorship-author-name">Tóthfalusi László</span> <span class="authorAux-mtmt"> Farmakometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001718"><a href="/gui2/?type=authors&mode=browse&sel=10001718" target="_blank">Baczkó István<sup>**</sup> (<span class="authorship-author-name">Baczkó István</span> <span class="authorAux-mtmt"> Kardiovaszkuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026898"><a href="/gui2/?type=authors&mode=browse&sel=10026898" target="_blank">Giricz Zoltán<sup>**</sup> ✉ (<span class="authorship-author-name">Giricz Zoltán</span> <span class="authorAux-mtmt"> Biokémia, Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter ✉ (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31203017" target="_blank">Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">3</span> <span class="page"> Paper 551. 17 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells9030551" target="_blank" href="https://doi.org/10.3390/cells9030551"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000529337400028" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000529337400028"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8448" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8448"> SE Repozitórium </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="115670" target="_blank" href="http://real.mtak.hu/115670"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85086863280" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85086863280"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32111102" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32111102&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="18357" target="_blank" href="http://publicatio.bibl.u-szeged.hu/18357"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 25</span> | Független: 12 | Függő: 13 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt:&nbsp;25 | WoS/Scopus jelölt:&nbsp;25 | DOI jelölt:&nbsp;25 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31203017&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31203017</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, A szívizom repolarizációs rezerv proaritmiás szerepének tisztázása krónikus betegség modellekben(K-128851) Támogató: NKFIH, GINOP-2.3.2-15-2016-00040(GINOP-2.3.2-15-2016-00040) Támogató: NKFIH, (ÚNKP-18-4), (UNKP-19-3-I-SE-60) </div> <div class="lastModified">Utolsó módosítás: 2026.04.16. 09:24 Csernyik Rita (MTMT központi admin) </div> <div class="lockedBy">Központi kezelésű 2024.09.09. 09:21 Kovács Marcell (MTMT Közp., admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>