{ "labelLang" : "hun", "responseDate" : "2024-03-29 00:13", "content" : { "otype" : "JournalArticle", "mtid" : 31189452, "status" : "APPROVED", "published" : true, "comment" : "Department of Clinical Pathology, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt \n Department of Rheumatology and Rehabilitation, Faculty of Medicine, Beni Suef University, Kornish Elnile, Borg Elsafa, Beni Suef, 002082, Egypt \n Export Date: 21 February 2020 \n CODEN: CJIMF \n Correspondence Address: Abdelaleem, E.A.; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Beni Suef UniversityEgypt; email: dr.enas2000@gmail.com \n Chemicals/CAS: C reactive protein, 9007-41-4; rheumatoid factor, 9009-79-4\nDepartment of Clinical Pathology, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt \n Department of Rheumatology and Rehabilitation, Faculty of Medicine, Beni Suef University, Kornish Elnile, Borg Elsafa, Beni Suef, 002082, Egypt \n Export Date: 21 July 2021 \n CODEN: CJIMF \n Correspondence Address: Abdelaleem, E.A.; Department of Rheumatology and Rehabilitation, Egypt; email: dr.enas2000@gmail.com \n Chemicals/CAS: C reactive protein, 9007-41-4; rheumatoid factor, 9009-79-4", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-09-18T10:08:23.113+0000", "lastModified" : "2020-02-21T09:42:01.609+0000", "created" : "2020-02-21T09:40:49.881+0000", "creator" : { "otype" : "Admin", "mtid" : 10028537, "link" : "/api/admin/10028537", "label" : "Baczkó Gabriella (SZTE ÁOK admin5 Reuma és Farmakológia)", "familyName" : "Baczkó", "givenName" : "Gabriella", "published" : true, "oldId" : 10028537, "snippet" : true }, "lastDuplumSearch" : "2023-09-13T10:55:19.578+0000", "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" 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"snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Tumour necrosis factor gene polymorphisms in Egyptian patients with rheumatoid arthritis and their relation to disease activity and severity", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 16652073, "link" : "/api/publicationidentifier/16652073", "label" : "DOI: 10.5114/ceji.2019.89602", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.5114/ceji.2019.89602", "realUrl" : "https://doi.org/10.5114/ceji.2019.89602", "published" : false, "snippet" : true }, { "otype" : 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"/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85078199810", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85078199810", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10015570, "link" : "/api/journal/10015570", "label" : "CENTRAL-EUROPEAN JOURNAL OF IMMUNOLOGY 1426-3912 1644-4124", "pIssn" : "1426-3912", "eIssn" : "1644-4124", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10015570, "snippet" : true }, "volume" : "44", "issue" : "3", "firstPage" : "277", "lastPage" : "284", "firstPageOrInternalIdForSort" : "277", "pageLength" : 8, "publishedYear" : 2019, "abstractText" : "Aim of the study: The present case control study was conducted to assess the association of LTA 252 A>G, TNF-α 308 G>A, and TNF-α 1031 T>C gene polymorphisms with rheumatoid arthritis (RA), and their involvement in disease activity and severity. Material and methods: A total of 70 Egyptians, including 35 RA patients and 35 healthy control individuals, were included in the study. The RA patients comprised 34 females and one male. Cases with RA were diagnosed by a rheumatologist and fulfilled the 2010 ACR/EULAR criteria. Modified disease activity score (DAS28) was used to assess disease activity. Van Der Heijde-modified Sharp score (vdHSS) was used to assess radiological changes for assessment of disease severity. PCR-RFLP was used to detect the association of LTA 252 A>G, TNF-α 308 G>A, and TNF-α 1031 T>C gene polymorphisms with RA. Results: TNF-α 308 G allele and TNF-α 308 GG genotype were significantly higher in RA patients compared to healthy control subjects (p = 0.04 and p = 0.001, respectively). TNF-α 308 G allele and GG genotype were significantly higher in the RA non-remission group compared to the remission group (p = 0.008, p < 0.001). Patients with the TNF-α 308 AG genotype had higher mean of Sharp score compared to the patients with the GG and AA genotypes (p = 0.007). There was no significant association between LTA 252 A>G and TNF-α 1031 T>C gene polymorphisms and RA. Conclusions: Our results suggest that TNF-α 308 G/A gene polymorphism is genetically associated with RA and involved in disease activity and severity in Egyptian patients. © 2019 Termedia Publishing House Ltd.. 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