https://m2.mtmt.hu/ eng 2026-10-25 09:48 JournalArticle 3117280 VALIDATED true Clinical Pharmacology Unit, Department of Health, Alicante - General Hospital, c/ Pintor Baeza, 12, Alicante, 03010, Spain Neuropharmacology on Pain and Functional Diversity (NED), Research Unit, Department of Health, Alicante - General Hospital, ISABIAL, Alicante, Spain Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary MTASE- NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary Neuroscience and Psychiatry Unit, University of Manchester, UK, Manchester Academic Health Sciences Centre, Manchester, United Kingdom MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Budapest, Hungary Université Clermont Auvergne, Université d'Auvergne, NEURO-DOL, Clermont-Ferrand, France Inserm, UMR 1107, NEURO-DOL, Clermont-Ferrand, France CHU Clermont-Ferrand, Medical Pharmacology Service, Clermont-Ferrand, France Hungarian Academy of Sciences, Budapest, Hungary CICAB Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz, Spain Cited By :11 Export Date: 11 October 2021 Correspondence Address: Peiró, A.M.; Clinical Pharmacology Unit, c/ Pintor Baeza, 12, Spain; email: peiro-ana@gva.es 0 2018-02-19T13:22:39.000+0000 false 3117280 2026-10-07T11:47:44.621+0000 2023-05-18T10:36:19.005+0000 2016-09-27T06:49:32.000+0000 true 10030040 Ruzsits Ágnes /api/admin/10030040 Admin true 10030040 2026-01-12T09:29:38.255+0000 2026-01-12T09:29:38.255+0000 2023-05-18T10:36:19.315+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Peiro, AM Pharmacogenomics in pain treatment true false /api/journal/10053105 REVIEWED true false 10053105 false 10053105 true 2363-8907 2363-8915 Journal FOREIGN 31 3 131 142 131 12 2016 The experience of chronic pain is one of the commonest reasons for seeking medical attention, being a major issue in clinical practice. While pain is a universal experience, only a small proportion of people who felt pain develop pain syndromes. In addition, painkillers are associated with wide inter-individual variability in the analgesic response. This may be partly explained by the presence of single nucleotide polymorphisms in genes encoding molecular entities involved in pharmacodynamics and pharmacokinetics. However, uptake of this information has been slow due in large part to the lack of robust evidences demonstrating clinical utility. Furthermore, novel therapies, including targeting of epigenetic changes and gene therapy-based approaches are further broadening future options for the treatment of chronic pain. The aim of this article is to review the evidences behind pharmacogenetics (PGx) to individualize therapy (boosting the efficacy and minimizing potential toxicity) and genes implicated in pain medicine, in two parts: (i) genetic variability with pain sensitivity and analgesic response; and (ii) pharmacological concepts applied on PGx. 2016 677626 true true true false true false GOLD 2026-10-07 true https://doi.org/10.1515/dmpt-2016-0005 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 19 0 19 13 0 16 16 12 16 16 16 10 10 13 6 0 19 13 19 13 0 1 1 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 4 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 3 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 1 0 1 0 2018 0 3 1 3 1 2019 0 3 2 3 2 2020 0 5 3 5 3 2021 0 3 3 3 3 2022 0 2 2 2 2 2023 0 0 0 0 0 2024 0 1 1 1 1 2025 0 0 0 0 0 2026 0 1 1 1 1 Q2 false false false false 2018-02-19T13:22:39.000+0000 2016-09-27T13:44:32.000+0000 Gyógyszerhatástani Intézet (SE / GYTK); MTA-SE Neuropszichofarmakológiai és Neurokémiai... (SE / GYTK / GYHATAS); MTA-SE-NAP B Genetikai Agyi Képalkotó Migrén Ku... (SE / GYTK / GYHATAS); Molekuláris Farmakológia Kutatócsoport (KOKI / GYO) 3 24 4 9 0 false 10066925 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 8271215 /api/authorship/8271215 1 0.111 true false true Peiro AM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809972 true PersonAuthorship 8271216 /api/authorship/8271216 2 0.11111111 false false Planelles B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809971 true PersonAuthorship 8271217 /api/authorship/8271217 3 0.111 false false Author 10017483 /api/author/10017483 Juhász Gabriella true 10017483 true Juhasz G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809970 true PersonAuthorship 8271218 /api/authorship/8271218 4 0.111 false false Author 10001318 /api/author/10001318 Bagdy György true 10001318 true Bagdy G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809969 true PersonAuthorship 8271219 /api/authorship/8271219 5 0.11111111 false false Libert F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809968 true PersonAuthorship 8271220 /api/authorship/8271220 6 0.11111111 false false Eschalier A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809967 true PersonAuthorship 8271221 /api/authorship/8271221 7 0.11111111 false false Busserolles J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809966 true PersonAuthorship 8271222 /api/authorship/8271222 8 0.111 false false Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlagh B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809965 true PersonAuthorship 8271223 /api/authorship/8271223 9 0.11111111 false true Llerena A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24809964 true PublicationIdentifier 1130093 /api/publicationidentifier/1130093 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD false IDENTICAL 10.1515/dmpt-2016-0005 https://doi.org/10.1515/dmpt-2016-0005 false 1460368 true PublicationIdentifier 1130096 /api/publicationidentifier/1130096 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true false NO 43388 https://real.mtak.hu/43388 false 1540755 true PublicationIdentifier 1130097 /api/publicationidentifier/1130097 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true GREEN false IDENTICAL 3818 https://repo.lib.semmelweis.hu/handle/123456789/3818 false 1491605 true PublicationIdentifier 1130092 /api/publicationidentifier/1130092 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84989166071 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84989166071 false 1581897 true PublicationIdentifier 1130095 /api/publicationidentifier/1130095 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 27662648 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27662648&dopt=Abstract false 1460369 true PublicationIdentifier 1130094 /api/publicationidentifier/1130094 PlainSource 12 /api/publicationsource/12 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Google scholar http://scholar.Google.com/scholar?hl=en&lr=&cluster=@@@ true true 12 true false NO 6614789960564368356 http://scholar.Google.com/scholar?hl=en&lr=&cluster=6614789960564368356 false 1631992 true Classification 12125 /api/classification/12125 true true Classification 12215 /api/classification/12215 true true SjrRating 10955807 /api/sjrrating/10955807 30 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3001 /api/classificationexternal/3001 true 3001 true Q2 DIRECT true true /api/publication/3117280 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Peiro AM ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Planelles B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017483"><a href="/gui2/?type=authors&mode=browse&sel=10017483" target="_blank">Juhasz G (<span class="authorship-author-name">Juhász Gabriella</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001318"><a href="/gui2/?type=authors&mode=browse&sel=10001318" target="_blank">Bagdy G (<span class="authorship-author-name">Bagdy György</span> <span class="authorAux-mtmt"> Neuropszichofarmakológia, gyógyszertan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics; <span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/<span title="Department of Pharmacodynamics">DP</span>/MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Budapest, Hungary</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Libert F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eschalier A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Busserolles J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Llerena A </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3117280" target="_blank">Pharmacogenomics in pain treatment</a></div> <div> <span class="journal-title">DRUG METABOLISM AND PERSONALIZED THERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2363-8907">2363-8907</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2363-8915">2363-8915</a>)</span>: <span class="journal-volume">31</span> <span class="journal-issue">3</span> <span class="page"> pp 131-142 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1515/dmpt-2016-0005" target="_blank" href="https://doi.org/10.1515/dmpt-2016-0005"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="43388" target="_blank" href="https://real.mtak.hu/43388"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="3818" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/3818"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84989166071" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84989166071"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27662648" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27662648&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="6614789960564368356" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=6614789960564368356"> Google scholar </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 19</span> | Independent citation: 13 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;16 | WoS/Scopus assigned:&nbsp;16 | Number of citations with DOI:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3117280&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3117280</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3117280</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.05.18. 12:36 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:20 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Clinical Pharmacology Unit, Department of Health, Alicante - General Hospital, c/ Pintor Baeza, 12, Alicante, 03010, Spain Neuropharmacology on Pain and Functional Diversity (NED), Research Unit, Department of Health, Alicante - General Hospital, ISABIAL, Alicante, Spain Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, B...</pre> </div></div>