This volume is essential for geneticists, molecular biologists, biochemists, and medical
doctors interested in the use of mouse models in cancer research. Recent genome studies,
together with refined genetic engineering techniques, have greatly increased the value
of using mice for research on cancer and other human disorders. The chapters of this
book will support scientists in choosing the most suitable mouse models for their
research questions. The book provides detailed methodological information for genetic
or chemical induction of different types of cancer, histomorphometric cancer analysis,
and in vivo imaging, as well as protocols to investigate oncogene addiction, immune
surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like
articles provide background information on mouse technologies and histopathologic
differences between mouse and human cancers. The mouse models described in individual
chapters will fuel the understanding of cancer initiation, immune system roles, tumor
angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed
among human cancers. Written in the highly successful Methods in Molecular Biology
series format, chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily reproducible laboratory
protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a
valuable laboratory resource for all researchers, from the graduate level upwards,
who study cancer and new possibilities for its treatment.
