https://m2.mtmt.hu/ hun 2026-04-15 12:52 JournalArticle 31168342 VALIDATED true 0 false 2026-04-13T06:33:52.626+0000 2024-11-29T08:57:47.985+0000 2020-02-10T13:16:47.517+0000 true 10065973 Pastyik Edit /api/admin/10065973 Admin true 2026-02-08T20:23:26.557+0000 2026-02-08T20:23:26.557+0000 2024-11-29T08:57:48.541+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10099440 /api/admin/10099440 Csernyik Rita true true 2026-03-02T07:06:31.914+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Paz-Ares, Luis Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN) a randomised, controlled, open-label, phase 3 trial true true /api/journal/3012 REVIEWED true false 3012 false 3012 true 0140-6736 1474-547X Journal FOREIGN 394 10212 1929 1939 1929 11 2019 Most patients with small-cell lung cancer (SCLC) have extensive-stage disease at presentation, and prognosis remains poor. Recently, immunotherapy has demonstrated clinical activity in extensive-stage SCLC (ES-SCLC). The CASPIAN trial assessed durvalumab, with or without tremelimumab, in combination with etoposide plus either cisplatin or carboplatin (platinum-etoposide) in treatment-naive patients with ES-SCLC.This randomised, open-label, phase 3 trial was done at 209 sites across 23 countries. Eligible patients were adults with untreated ES-SCLC, with WHO performance status 0 or 1 and measurable disease as per Response Evaluation Criteria in Solid Tumors, version 1.1. Patients were randomly assigned (in a 1:1:1 ratio) to durvalumab plus platinum-etoposide; durvalumab plus tremelimumab plus platinum-etoposide; or platinum-etoposide alone. All drugs were administered intravenously. Platinum-etoposide consisted of etoposide 80-100 mg/m2 on days 1-3 of each cycle with investigator's choice of either carboplatin area under the curve 5-6 mg/mL per min or cisplatin 75-80 mg/m2 (administered on day 1 of each cycle). Patients received up to four cycles of platinum-etoposide plus durvalumab 1500 mg with or without tremelimumab 75 mg every 3 weeks followed by maintenance durvalumab 1500 mg every 4 weeks in the immunotherapy groups and up to six cycles of platinum-etoposide every 3 weeks plus prophylactic cranial irradiation (investigator's discretion) in the platinum-etoposide group. The primary endpoint was overall survival in the intention-to-treat population. We report results for the durvalumab plus platinum-etoposide group versus the platinum-etoposide group from a planned interim analysis. Safety was assessed in all patients who received at least one dose of their assigned study treatment. This study is registered at ClinicalTrials.gov, NCT03043872, and is ongoing.Patients were enrolled between March 27, 2017, and May 29, 2018. 268 patients were allocated to the durvalumab plus platinum-etoposide group and 269 to the platinum-etoposide group. Durvalumab plus platinum-etoposide was associated with a significant improvement in overall survival, with a hazard ratio of 0·73 (95% CI 0·59-0·91; p=0·0047]); median overall survival was 13·0 months (95% CI 11·5-14·8) in the durvalumab plus platinum-etoposide group versus 10·3 months (9·3-11·2) in the platinum-etoposide group, with 34% (26·9-41·0) versus 25% (18·4-31·6) of patients alive at 18 months. Any-cause adverse events of grade 3 or 4 occurred in 163 (62%) of 265 treated patients in the durvalumab plus platinum-etoposide group and 166 (62%) of 266 in the platinum-etoposide group; adverse events leading to death occurred in 13 (5%) and 15 (6%) patients.First-line durvalumab plus platinum-etoposide significantly improved overall survival in patients with ES-SCLC versus a clinically relevant control group. Safety findings were consistent with the known safety profiles of all drugs received.AstraZeneca. true true 2020 true true true false true false CLOSED 2026-04-13 false 1948 0 1948 1562 25 1936 1923 1790 1877 1948 1948 1562 1562 1562 386 0 1948 1562 1948 1562 0 3 3 Folyóiratcikk Journal Article 24 1919 Könyvrészlet Chapter in Book 25 27 Könyv Book 23 2 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 1 1 1 1 2020 0 183 150 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journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/31168342 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Paz-Ares Luis ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dvorkin Mikhail </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen Yuanbin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reinmuth Niels </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hotta Katsuyuki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Trukhin Dmytro </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Statsenko Galina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hochmair Maximilian J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Özgüroğlu Mustafa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ji Jun Ho </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Voitko Oleksandr </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Poltoratskiy Artem </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ponce Santiago </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Verderame Francesco </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Havel Libor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bondarenko Igor </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kazarnowicz Andrzej </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004124"><a href="/gui2/?type=authors&mode=browse&sel=10004124" target="_blank">Losonczy György (<span class="authorship-author-name">Losonczy György</span> <span class="authorAux-mtmt"> Pulmonológia, klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Conev Nikolay V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Armstrong Jon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Byrne Natalie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shire Norah </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jiang Haiyi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goldman Jonathan W </span> </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" >Batagelj Emilio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003497"><a href="/gui2/?type=authors&mode=browse&sel=10003497" target="_blank">Bogos Krisztina (<span class="authorship-author-name">Bogos Krisztina</span> <span class="authorAux-mtmt"> Tüdőgyógyászat, Klinikai Onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026959"><a href="/gui2/?type=authors&mode=browse&sel=10026959" target="_blank">Horváth Zsolt (<span class="authorship-author-name">Horváth Zsolt</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004124"><a href="/gui2/?type=authors&mode=browse&sel=10004124" target="_blank">Losonczy György (<span class="authorship-author-name">Losonczy György</span> <span class="authorAux-mtmt"> Pulmonológia, klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035747"><a href="/gui2/?type=authors&mode=browse&sel=10035747" target="_blank">Pápai Zsuzsanna (<span class="authorship-author-name">Pápai Zsuzsanna</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028723"><a href="/gui2/?type=authors&mode=browse&sel=10028723" target="_blank">Sárosi Veronika (<span class="authorship-author-name">Sárosi Veronika</span> <span class="authorAux-mtmt"> Tüdőgyógyászat, onkológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Általános Orvostudományi Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028618"><a href="/gui2/?type=authors&mode=browse&sel=10028618" target="_blank">Somfay Attila (<span class="authorship-author-name">Somfay Attila</span> <span class="authorAux-mtmt"> Tüdőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Tüdőgyógyászati Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075905"><a href="/gui2/?type=authors&mode=browse&sel=10075905" target="_blank">Somogyiné Ezer Éva (<span class="authorship-author-name">Somogyiné Ezer Éva</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil">Somogy Megyei Kaposi Mór Oktató Kórház</span> ;&nbsp;&nbsp;&nbsp; et al. (222) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">CASPIAN investigators</span> </div> <div><a target="_blank" href="/api/publication/31168342?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31168342" target="_blank">Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN) : a randomised, controlled, open-label, phase 3 trial.</a></div> <div> <span class="journal-title">LANCET</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0140-6736">0140-6736</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-547X">1474-547X</a>)</span>: <span class="journal-volume">394</span> <span class="journal-issue">10212</span> <span class="page"> pp 1929-1939 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1016/S0140-6736(19)32222-6" target="_blank" href="https://doi.org/10.1016/S0140-6736%2819%2932222-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000498868500027" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000498868500027"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85075219567" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85075219567"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31590988" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31590988&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="29981" target="_blank" href="http://publicatio.bibl.u-szeged.hu/29981"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Demográfiai Osztályközi Állandó Bizottság IXGJO DEM [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1,948</span> | Független: 1,562 | Függő: 386 | Nem jelölt: 0 | WoS jelölt: 1,790 | Scopus jelölt:&nbsp;1,877 | WoS/Scopus jelölt:&nbsp;1,948 | DOI jelölt:&nbsp;1,923 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31168342&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31168342</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.29. 09:57 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2026.03.02. 08:06 Csernyik Rita (MTMT központi admin) </div> </div></div>