The Neuroprotective and Biomarker Potential of PACAP in Human Traumatic Brain Injury.

Toth, Denes [Tóth, Dénes (Igazságügyi orvostan), szerző] Igazságügyi Orvostani Intézet (PTE / ÁOK); Tamas, Andrea [Tamás, Andrea (Idegtudomány), szerző] Anatómiai Intézet (PTE / ÁOK); MTA-PTE PACAP Kutatócsoport (PTE / KCS); Reglodi, Dora [Reglődi, Dóra (Idegtudományok), szerző] Anatómiai Intézet (PTE / ÁOK); MTA-PTE PACAP Kutatócsoport (PTE / KCS)

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
Megjelent: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 21 (3) Paper: 827 , 11 p. 2020
  • SJR Scopus - Computer Science Applications: D1
    Traumatic brain injury remains a growing public health concern and represents the greatest contributor to death and disability globally among all trauma-related injuries. There are limited clinical data regarding biomarkers in the diagnosis and outcome prediction of TBI. The lack of real effective treatment for recovery calls for research of TBI to be shifted into the area of prevention, treatment of secondary brain injury and neurorehabilitation. The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been reported to act as a hormone, a neuromodulator, a neurotransmitter and a trophic factor, and has been implicated in a variety of developmental and regenerative processes. The importance of PACAP in neuronal regeneration lies in the upregulation of endogenous PACAP and its receptors and the protective effect of exogenous PACAP after different central nervous system injury. The aim of this minireview is to summarize both the therapeutic and biomarker potential of the neuropeptide PACAP, as a novel possible target molecule presently being investigated in several human conditions including TBI, and with encouraging results in animal models of TBI.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2022-01-24 23:32