https://m2.mtmt.hu/ hun 2026-04-30 09:44 JournalArticle 3115066 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 3115066 2026-01-30T09:41:22.286+0000 2026-01-22T07:46:33.927+0000 2016-09-21T08:37:03.000+0000 true 10000109 Győrffy Balázs /api/author/10000109 Author true 10000109 2026-01-22T07:46:35.471+0000 2026-01-22T07:46:35.471+0000 2024-12-06T17:42:30.988+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Santarpia, L Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer true true /api/journal/10001321 REVIEWED true false 10001321 false 10001321 true 1083-7159 1549-490X Journal FOREIGN 21 9 1063 1078 1063 16 2016 : Advances in DNA and RNA sequencing revealed substantially greater genomic complexity in breast cancer than simple models of a few driver mutations would suggest. Only very few, recurrent mutations or copy-number variations in cancer-causing genes have been identified. The two most common alterations in breast cancer are TP53 (affecting the majority of triple-negative breast cancers) and PIK3CA (affecting almost half of estrogen receptor-positive cancers) mutations, followed by a long tail of individually rare mutations affecting <1%-20% of cases. Each cancer harbors from a few dozen to a few hundred potentially high-functional impact somatic variants, along with a much larger number of potentially high-functional impact germline variants. It is likely that it is the combined effect of all genomic variations that drives the clinical behavior of a given cancer. Furthermore, entirely new classes of oncogenic events are being discovered in the noncoding areas of the genome and in noncoding RNA species driven by errors in RNA editing. In light of this complexity, it is not unexpected that, with the exception of HER2 amplification, no robust molecular predictors of benefit from targeted therapies have been identified. In this review, we summarize the current genomic portrait of breast cancer, focusing on genetic aberrations that are actively being targeted with investigational drugs. IMPLICATIONS FOR PRACTICE: Next-generation sequencing is now widely available in the clinic, but interpretation of the results is challenging, and its impact on treatment selection is often limited. This work provides an overview of frequently encountered molecular abnormalities in breast cancer and discusses their potential therapeutic implications. This review emphasizes the importance of administering investigational targeted therapies, or off-label use of approved targeted drugs, in the context of a formal clinical trial or registry programs to facilitate learning about the clinical utility of tumor target profiling. 2016 581181 true true true false true false CLOSED 2026-01-30 false true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 51 0 51 45 4 49 46 48 46 51 51 45 45 45 6 0 51 45 51 45 0 8 8 Folyóiratcikk Journal Article 24 49 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 4 2 4 2 2017 0 9 7 9 7 2018 0 10 9 10 9 2019 0 6 5 6 5 2020 0 6 6 6 6 2021 0 7 7 7 7 2022 0 4 4 4 4 2023 0 0 0 0 0 2024 0 1 1 1 1 2025 0 4 4 4 4 D1 false false false false 2017-11-22T15:50:30.000+0000 2016-09-21T08:38:00.000+0000 II. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); II. Sz. 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Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pusztai L ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3115066" target="_blank">Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer</a></div> <div> <span class="journal-title">ONCOLOGIST</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1083-7159">1083-7159</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1549-490X">1549-490X</a>)</span>: <span class="journal-volume">21</span> <span class="journal-issue">9</span> <span class="page"> pp 1063-1078 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1634/theoncologist.2015-0369" target="_blank" href="https://doi.org/10.1634/theoncologist.2015-0369"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="46184" target="_blank" href="http://real.mtak.hu/46184"> REAL </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="4042" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/4042"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000383393600007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000383393600007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84987995246" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84987995246"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27384237" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27384237&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 51</span> | Független: 45 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 48 | Scopus jelölt:&nbsp;46 | WoS/Scopus jelölt:&nbsp;51 | DOI jelölt:&nbsp;46 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3115066&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3115066</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3115066</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.22. 08:46 Mátics Bernadett (OOI admin5) </div> </div></div>