Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive
disease in adult patients: a new classification from the European Society for Blood
and Marrow Transplantation
Mohty, M ✉; Malard, F*; Abecassis, M*; Aerts, E*; Alaskar, AS*; Aljurf, M*; Arat, M*; Bader, P*; Baron, F*; Bazarbachi, A*; Blaise, D*; Ciceri, F*; Corbacioglu, S*; Dalle, JH*; Dignan, F*; Fukuda, T*; Huynh, A*; Masszi, T* [Masszi, Tamás (Belgyógyászat, ha...), author] III. Department of Internal
Medicine (SU / FM / C); Michallet, M*; Nagler, A*; NiChonghaile, M*; Okamoto, S*; Pagliuca, A*; Peters, C*; Petersen, FB*; Richardson, PG*; Ruutu, T*; Savani, BN*; Wallhult, E*; Yakoub-Agha, I*; Duarte, RF*; Carreras, E*
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is
a potentially life threatening complication that can develop after hematopoietic cell
transplantation. Although SOS/VOD progressively resolves within a few weeks in most
patients, the most severe forms result in multi-organ dysfunction and are associated
with a high mortality rate (480%). Therefore, careful attention must be paid to allow
an early detection of SOS/VOD, particularly as drugs have now proven to be effective
and licensed for its treatment. Unfortunately, current criteria lack sensitivity and
specificity, making early identification and severity assessment of SOS/VOD difficult.
The aim of this work is to propose a new definition for diagnosis, and a severity-grading
system for SOS/VOD in adult patients, on behalf of the European Society for Blood
and Marrow Transplantation.
