Fizikai kémia, polimertudomány, elektrokémia (szárazelemek, akkumulátorok, üzemanyagcellák,
fémek korróziója, elektrolízis)
Kémiai tudományok
Természettudományok
Tudomány
Although accumulating evidence suggests that the crosstalk between malignant cells
and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth and
metastatic dissemination, therapeutic strategies targeting tumour stroma are still
not common in the clinical practice. Metal-based nanomaterials have been shown to
exert excellent cytotoxic and anti-cancerous activities, however, their effects on
the reactive stroma have never been investigated in details. Thus, using feasible
in vitro and in vivo systems to model tumour microenvironment, we tested whether the
presence of gold, silver or gold-core silver-shell nanoparticles exerts anti-tumour
and metastasis suppressing activities by influencing the tumour-supporting activity
of stromal fibroblasts.
