https://m2.mtmt.hu/ eng 2026-07-27 13:49 JournalArticle 31138120 VALIDATED true 0 false 2026-05-19T17:51:29.014+0000 2026-03-26T10:42:42.641+0000 2020-01-23T11:58:40.545+0000 true 10018922 Lazáry Áron /api/author/10018922 Author true 10018922 2026-03-26T10:42:42.837+0000 2026-03-26T10:42:42.837+0000 2021-02-24T14:09:57.564+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true 2026-03-03T09:19:14.582+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Rijsbergen, Marc van Comparison of patient-specific computational models vs. clinical follow-up, for adjacent segment disc degeneration and bone remodelling after spinal fusion true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 13 8 e0200899 e0200899 24 2018 Spinal fusion is a standard surgical treatment for patients suffering from low back pain attributed to disc degeneration. However, results are somewhat variable and unpredictable. With fusion the kinematic behaviour of the spine is altered. Fusion and/or stabilizing implants carrying considerable load and prevent rotation of the fused segments. Associated with these changes, a risk for accelerated disc degeneration at the adjacent levels to fusion has been demonstrated. However, there is yet no method to predict the effect of fusion surgery on the adjacent tissue levels, i.e. bone and disc. The aim of this study was to develop a coupled and patient-specific mechanoregulated model to predict disc generation and changes in bone density after spinal fusion and to validate the results relative to patient follow-up data. To do so, a multiscale disc mechanoregulation adaptation framework was developed and coupled with a previously developed bone remodelling algorithm. This made it possible to determine extra cellular matrix changes in the intervertebral disc and bone density changes simultaneously based on changes in loading due to fusion surgery. It was shown that for 10 cases the predicted change in bone density and degeneration grade conforms reasonable well to clinical follow-up data. This approach helps us to understand the effect of surgical intervention on the adjacent tissue remodelling. Thereby, providing the first insight for a spine surgeon as to which patient could potentially be treated successfully by spinal fusion and in which patient has a high risk for adjacent tissue changes. 2020 true true true false true false GOLD 2026-05-19 true https://doi.org/10.1371/journal.pone.0200899 44 0 44 30 5 44 43 42 38 44 44 30 30 30 14 0 44 30 44 30 0 1 1 Folyóiratcikk Journal Article 24 43 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 2 1 2 1 2020 0 4 3 4 3 2021 0 17 10 17 10 2022 0 7 4 7 4 2023 0 5 3 5 3 2024 0 2 2 2 2 2025 0 5 5 5 5 2026 0 2 2 2 2 Q1 A false false false false 2020-04-22T11:10:23.237+0000 2 8 0 10 0 true 10003134 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 90452312 /api/authorship/90452312 1 0.1 true false false Rijsbergen Marc van true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452313 /api/authorship/90452313 2 0.1 false false true van Rietbergen Bert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452314 /api/authorship/90452314 3 0.1 false false false Barthelemy Veronique true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84602835 /api/authorship/84602835 4 0.1 false false Author 10048475 /api/author/10048475 Éltes Péter Endre true 10048475 true Eltes Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452316 /api/authorship/90452316 5 0.1 false false false Author 10018922 /api/author/10018922 Lazáry Áron true 10018922 true Lazáry Áron true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452317 /api/authorship/90452317 6 0.1 false false false Lacroix Damien true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452318 /api/authorship/90452318 7 0.1 false false false Noailly Jérôme true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452319 /api/authorship/90452319 8 0.1 false false false Ho Ba Tho Marie-Christine true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452320 /api/authorship/90452320 9 0.1 false false false Wilson Wouter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 90452321 /api/authorship/90452321 10 0.1 false true false Ito Keita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16545924 /api/publicationidentifier/16545924 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0200899 https://doi.org/10.1371/journal.pone.0200899 false true PublicationIdentifier 16355702 /api/publicationidentifier/16355702 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000443388900004 https://www.webofscience.com/wos/woscc/full-record/000443388900004 true true PublicationIdentifier 16355710 /api/publicationidentifier/16355710 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85052880704 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85052880704 true true PublicationIdentifier 16545923 /api/publicationidentifier/16545923 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 30161138 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30161138&dopt=Abstract false true MtaRating 10486385 /api/mtarating/10486385 RatingType 10023 /api/ratingtype/10023 PedTB Institute 14107 /api/institute/14107 0 false true false Pedagógiai Tudományos Bizottság Pedagógiai Tudományos Bizottság true 14107 true true true A true true MtaRating 519076 /api/mtarating/519076 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19076 true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 10976076 /api/sjrrating/10976076 34 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1101 /api/classificationexternal/1101 true 1101 true Q1 DIRECT true true /api/publication/31138120 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Rijsbergen Marc van </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >van Rietbergen Bert ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barthelemy Veronique </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048475"><a href="/gui2/?type=authors&mode=browse&sel=10048475" target="_blank">Eltes Peter (<span class="authorship-author-name">Éltes Péter Endre</span> <span class="authorAux-mtmt"> mozgásszervek biomechanikája</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018922"><a href="/gui2/?type=authors&mode=browse&sel=10018922" target="_blank">Lazáry Áron (<span class="authorship-author-name">Lazáry Áron</span> <span class="authorAux-mtmt"> Gerincsebész</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lacroix Damien </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Noailly Jérôme </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ho Ba Tho Marie-Christine </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wilson Wouter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ito Keita </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31138120" target="_blank">Comparison of patient-specific computational models vs. clinical follow-up, for adjacent segment disc degeneration and bone remodelling after spinal fusion</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">8</span> <span class="page"> Paper e0200899. 24 p. </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0200899" target="_blank" href="https://doi.org/10.1371/journal.pone.0200899"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000443388900004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000443388900004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85052880704" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85052880704"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30161138" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30161138&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 44</span> | Independent citation: 30 | Self citation: 14 | Unknown citation: 0 | Number of citations in WoS: 42 | Number of citations in Scopus:&nbsp;38 | WoS/Scopus assigned:&nbsp;44 | Number of citations with DOI:&nbsp;43 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31138120&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31138120</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2026.03.26. 11:42 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.03.03. 10:19 György Wolf (MTMT Központi admin) </div> </div></div>