NCX activity generates spontaneous Ca2+ oscillations in the astrocytic leaflet microdomain

Héja, L. ✉ [Héja, László (Neurokémia), szerző]; Kardos, J. ✉ [Kardos, Julianna (Neurokémia, az id...), szerző]

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: CELL CALCIUM 0143-4160 86 (March 2020) Paper: 102137 2020
  • SJR Scopus - Physiology: Q1
The synergy between synaptic Glu release and astrocytic Glu-Na+ symport is essential to the signalling function of the tripartite synapse. Here we used kinetic data of astrocytic Glu transporters (EAAT) and the Na+/Ca2+ exchanger (NCX) to simulate Glu release, Glu uptake and subsequent Na+ and Ca2+ dynamics in the astrocytic leaflet microdomain following single release event. Model simulations show that Glu-Na+ symport differently affect intracellular [Na+] in synapses with different extent of astrocytic coverage. Surprisingly, NCX activity alone has been shown to generate markedly stable, spontaneous Ca2+ oscillation in the astrocytic leaflet. These on-going oscillations appear when NCX operates either in the forward or reverse direction. We conjecture that intrinsic NCX activity may play a prominent role in the generation of astrocytic Ca2+ oscillations. © 2019 The Authors
Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
2020-07-07 09:04