https://m2.mtmt.hu/ hun 2026-09-22 20:17 JournalArticle 3111905 VALIDATED true Export Date: 30 April 2026; Cited By: 807; Correspondence Address: B. Gyorffy; MTA-TTK Lendület Cancer Biomarker Research Group, Budapest, Hungary; email: gyorffy.balazs@ttk.mta.hu; 0 2018-06-19T12:56:32.000+0000 false 3111905 2026-09-07T13:24:45.100+0000 2026-04-30T12:07:21.585+0000 2016-09-14T13:54:27.000+0000 true 10000041 Szabó András /api/author/10000041 Author true 10000041 2026-04-30T12:07:21.469+0000 2024-12-06T17:42:26.767+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szasz, AM Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. true true /api/journal/10022516 REVIEWED true false 10022516 false 10022516 true 1949-2553 Journal FOREIGN 7 31 49322 49333 49322 12 2016 INTRODUCTION: Multiple gene expression based prognostic biomarkers have been repeatedly identified in gastric carcinoma. However, without confirmation in an independent validation study, their clinical utility is limited. Our goal was to establish a robust database enabling the swift validation of previous and future gastric cancer survival biomarker candidates. RESULTS: The entire database incorporates 1,065 gastric carcinoma samples, gene expression data. Out of 29 established markers, higher expression of BECN1 (HR = 0.68, p = 1.5E-05), CASP3 (HR = 0.5, p = 6E-14), COX2 (HR = 0.72, p = 0.0013), CTGF (HR = 0.72, p = 0.00051), CTNNB1 (HR = 0.47, p = 4.3E-15), MET (HR = 0.63, p = 1.3E-05), and SIRT1 (HR = 0.64, p = 2.2E-07) correlated to longer OS. Higher expression of BIRC5 (HR = 1.45, p = 1E-04), CNTN1 (HR = 1.44, p = 3.5E- 05), EGFR (HR = 1.86, p = 8.5E-11), ERCC1 (HR = 1.36, p = 0.0012), HER2 (HR = 1.41, p = 0.00011), MMP2 (HR = 1.78, p = 2.6E-09), PFKB4 (HR = 1.56, p = 3.2E-07), SPHK1 (HR = 1.61, p = 3.1E-06), SP1 (HR = 1.45, p = 1.6E-05), TIMP1 (HR = 1.92, p = 2.2E- 10) and VEGF (HR = 1.53, p = 5.7E-06) were predictive for poor OS. MATERIALS AND METHODS: We integrated samples of three major cancer research centers (Berlin, Bethesda and Melbourne datasets) and publicly available datasets with available follow-up data to form a single integrated database. Subsequently, we performed a literature search for prognostic markers in gastric carcinomas (PubMed, 2012-2015) and re-validated their findings predicting first progression (FP) and overall survival (OS) using uni- and multivariate Cox proportional hazards regression analysis. CONCLUSIONS: The major advantage of our analysis is that we evaluated all genes in the same set of patients thereby making direct comparison of the markers feasible. 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Sz. Gyermekgyógyászati Klinika (SE / AOK / K); II. Sz. 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Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073052"><a href="/gui2/?type=authors&mode=browse&sel=10073052" target="_blank">Lanczky A (<span class="authorship-author-name">Lánczky András</span> <span class="authorAux-mtmt"> Bioinformatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047679"><a href="/gui2/?type=authors&mode=browse&sel=10047679" target="_blank">Nagy A (<span class="authorship-author-name">Nagy Ádám</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Forster S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hark K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Green JE </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Boussioutas A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Busuttil R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000041"><a href="/gui2/?type=authors&mode=browse&sel=10000041" target="_blank">Szabo A (<span class="authorship-author-name">Szabó András</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Gyorffy B ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/II. Sz. Gyermekgyógyászati Klinika; <span title="MTA Természettudományi Kutatóközpont">MTA TTK</span>/<span title="Enzimológiai Intézet">EI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3111905" target="_blank">Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients.</a></div> <div> <span class="journal-title">ONCOTARGET</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1949-2553">1949-2553</a>)</span>: <span class="journal-volume">7</span> <span class="journal-issue">31</span> <span class="page"> pp 49322-49333 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.18632/oncotarget.10337" target="_blank" href="https://doi.org/10.18632/oncotarget.10337"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="39758" target="_blank" href="https://real.mtak.hu/39758"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="3674" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/3674"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000385422000040" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000385422000040"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84981344780" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84981344780"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27384994" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27384994&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/84981344780?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/84981344780?origin=resultslist"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="PMC5226511" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226511"> Pubmed Central </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 860</span> | Független: 842 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 833 | Scopus jelölt:&nbsp;816 | WoS/Scopus jelölt:&nbsp;860 | DOI jelölt:&nbsp;821 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3111905&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3111905</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3111905</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.30. 14:07 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 30 April 2026; Cited By: 807; Correspondence Address: B. Gyorffy; MTA-TTK Lendület Cancer Biomarker Research Group, Budapest, Hungary; email: gyorffy.balazs@ttk.mta.hu;</pre> </div></div>