Higher body mass index is linked to altered hypothalamic microstructure

Thomas, K.; Beyer, F.; Lewe, G.; Zhang, R.; Schindler, S.; Schoenknecht, P.; Stumvoll, M.; Villringer, A.; Witte, A. V. ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: SCIENTIFIC REPORTS 2045-2322 9 Paper: 17373 , 11 p. 2019
  • Szociológiai Tudományos Bizottság: B
  • SJR Scopus - Multidisciplinary: D1
    Animal studies suggest that obesity-related diets induce structural changes in the hypothalamus, a key brain area involved in energy homeostasis. Whether this translates to humans is however largely unknown. Using a novel multimodal approach with manual segmentation, we here show that a higher body mass index (BMI) selectively predicted higher proton diffusivity within the hypothalamus, indicative of compromised microstructure in the underlying tissue, in a well-characterized population-based cohort (n(1) = 338, 48% females, age 21-78 years, BMI 18-43 kg/m(2)). Results were independent from confounders and confirmed in another independent sample (n(2) = 236). In addition, while hypothalamic volume was not associated with obesity, we identified a sexual dimorphism and larger hypothalamic volumes in the left compared to the right hemisphere. Using two large samples of the general population, we showed that a higher BMI specifically relates to altered microstructure in the hypothalamus, independent from confounders such as age, sex and obesity-associated co-morbidities. This points to persisting microstructural changes in a key regulatory area of energy homeostasis occurring with excessive weight. Our findings may help to better understand the pathomechanisms of obesity and other eating-related disorders.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-03-09 03:24