{ "labelLang" : "hun", "responseDate" : "2024-03-28 21:02", "content" : { "otype" : "JournalArticle", "mtid" : 31089821, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: AstraZeneca, Cambridge, UKAstraZeneca\n Funding text: The authors would like to thank the patients and investigators involved in each study. Medical writing support, under the direction of the authors, was provided by Mark Holland, PhD, of CMC Connect, a division of McCann Health Medical Communications Ltd, Manchester, UK and Karleen Nicholson PhD, on behalf of CMC Connect, funded by AstraZeneca, Cambridge, UK, in accordance with Good Publication Practice (GPP3) guidelines.\nDivision of Breast Surgery, The University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, United Kingdom \n Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, No. 8 Dongda Street, Fengtai District, Beijing, 100071, China \n “Sandro Pitigliani” Medical Oncology Department, Hospital of Prato, Azienda USL Toscana Centro, Piazza Dell’ospedale 2, Prato, 59100, Italy \n Breast Oncology Center, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan \n Sunnybrook Odette Cancer Centre and the University of Toronto, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada \n Lester and Sue Smith Breast Center, Baylor College of Medicine, 6620 S Main St #1350, Houston, TX 77030, United States \n Frontier Science, Grampian View, Kincraig, Kingussie, PH21 1NA, United Kingdom \n Cited By :1 \n Export Date: 16 June 2020 \n Correspondence Address: Robertson, J.F.R.; Division of Breast Surgery, The University of Nottingham, Nottingham City Hospital, Hucknall Road, United Kingdom; email: John.Robertson@nottingham.ac.uk\nDivision of Breast Surgery, The University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, United Kingdom \n Department of Breast Cancer, Affiliated Hospital of Academy of Military Medical Sciences, No. 8 Dongda Street, Fengtai District, Beijing, 100071, China \n “Sandro Pitigliani” Medical Oncology Department, Hospital of Prato, Azienda USL Toscana Centro, Piazza Dell’ospedale 2, Prato, 59100, Italy \n Breast Oncology Center, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan \n Sunnybrook Odette Cancer Centre and the University of Toronto, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada \n Lester and Sue Smith Breast Center, Baylor College of Medicine, 6620 S Main St #1350, Houston, TX 77030, United States \n Frontier Science, Grampian View, Kincraig, Kingussie, PH21 1NA, United Kingdom \n Cited By :2 \n Export Date: 15 August 2020 \n Correspondence Address: Robertson, J.F.R.; Division of Breast Surgery, The University of Nottingham, Nottingham City Hospital, Hucknall Road, United Kingdom; email: John.Robertson@nottingham.ac.uk", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-07-10T11:58:42.108+0000", "lastModified" : "2020-01-10T03:37:55.774+0000", "created" : "2020-01-10T03:37:54.765+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "validated" : "2020-01-10T03:37:54.854+0000", "validator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Robertson, John F. 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"volume" : "26", "issue" : "6", "firstPage" : "703", "lastPage" : "711", "firstPageOrInternalIdForSort" : "703", "pageLength" : 9, "publishedYear" : 2019, "abstractText" : "Background Fulvestrant, a selective estrogen receptor degrader, is approved for first- and second-line treatment of postmenopausal women with hormone receptor-positive advanced breast cancer (ABC).Methods Meta-analysis of randomized controlled trials (RCTs) evaluating fulvestrant 500 mg in postmenopausal hormone receptor-positive ABC, to evaluate differences in clinical benefit rate (CBR; proportion of patients experiencing best overall response of complete response, partial response, or stable disease for >= 24 weeks) between fulvestrant 500 mg and comparator endocrine therapies. Odds ratios (OR) and 95% confidence intervals (CI) for CBR were calculated; fixed effects (FE) models were constructed (first- and second-line data, alone and combined).Results Six RCTs were included. Four studies evaluated fulvestrant 500 mg vs. fulvestrant 250 mg; two evaluated fulvestrant 500 mg vs. anastrozole 1 mg. In total, 1054 and 534 patients were included (first- and second-line treatment, respectively). Analysis of OR and 95% CI of CBR by therapy line favored fulvestrant 500 mg vs. comparator therapy. Assessing all results combined in the FE model indicated significant improvement in CBR with fulvestrant 500 mg vs. comparator treatments (OR 1.33; 95% CI 1.13-1.57; p = 0.001). Restricting the FE model to therapy line demonstrated significant improvement in CBR vs. comparator treatments (OR 1.33; 95% CI 1.02-1.73; p = 0.035) for first-line, and a trend to improvement vs. comparator treatments (OR 1.27; 95% CI 0.90-1.79; p = 0.174) for second-line.Conclusions In postmenopausal patients with hormone receptor-positive ABC, fulvestrant 500 mg first-line was associated with significantly greater CBR (more patients benefiting from treatment) vs. comparator endocrine therapy.", "subjects" : [ { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 13575, "link" : "/api/keyword/13575", "label" : "Meta-analysis", "published" : true, "oldId" : 13575, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1079308, "link" : "/api/keyword/1079308", "label" : "fulvestrant", "published" : true, "oldId" : 1079308, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1562736, "link" : "/api/keyword/1562736", "label" : "hormone receptor-positive", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1562738, "link" : "/api/keyword/1562738", "label" : "advanced breast cancer", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1921162, "link" : "/api/keyword/1921162", "label" : "Clinical benefit rate", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2020, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-07-10", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10992145, "link" : "/api/sjrrating/10992145", "label" : "sjr:Q1 (2019) Scopus - Medicine (miscellaneous) BREAST CANCER: THE JOURNAL OF THE JAPANESE BREAST CANCER SOCIETY 1340-6868 1880-4233", "listPos" : 611, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2701, "link" : "/api/classificationexternal/2701", "label" : "Scopus - Medicine (miscellaneous)", "published" : true, "oldId" : 2701, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 3, "ownerInstituteCount" : 16, "directInstituteCount" : 0, "authorCount" : 8, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/31089821", "label" : "Robertson John F. et al. 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