A novel method for synthesis of tricyclic benzimidazole derivatives by using continuous
flow reactor is reported. Disadvantages of the well-known batch methods have been
avoided utilizing the flow chemistry technology. Beside the one pot reductive cyclization
using H-Cube Pro (R), the dehydration step was also optimized producing the desired
lactam compounds. Then the acylation was optimized under microwave conditions and
that reaction was also integrated into the flow system using an Asia heater module.
This acylation dramatically reduced the reaction time under continuous-flow conditions,
with a residence time of 30 min.
