https://m2.mtmt.hu/ hun 2026-05-01 13:05 JournalArticle 31083813 VALIDATED true Funding Agency and Grant Number: Eli Lilly and CompanyEli Lilly; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA008748] Funding Source: NIH RePORTER Funding text: Eli Lilly and Company. 0 false 2026-04-28T14:45:02.081+0000 2024-03-21T11:08:37.807+0000 2020-01-10T00:01:45.784+0000 true 565 WoS import /api/admin/565 Admin true 2025-09-19T08:28:32.028+0000 2025-09-19T08:28:32.028+0000 2024-03-21T11:08:38.206+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Gerstein, Hertzel C. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial true true /api/journal/3012 REVIEWED true false 3012 false 3012 true 0140-6736 1474-547X Journal FOREIGN 394 10193 121 130 121 10 2019 Background Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk with high glycated haemoglobin A 1c (HbA 1c) concentrations. We assessed the effect of the GLP-1 receptor agonist dulaglutide on major adverse cardiovascular events when added to the existing antihyperglycaemic regimens of individuals with type 2 diabetes with and without previous cardiovascular disease and a wide range of glycaemic control.Methods This multicentre, randomised, double-blind, placebo-controlled trial was done at 371 sites in 24 countries. Men and women aged at least 50 years with type 2 diabetes who had either a previous cardiovascular event or cardiovascular risk factors were randomly assigned (1: 1) to either weekly subcutaneous injection of dulaglutide (1.5 mg) or placebo. Randomisation was done by a computer-generated random code with stratification by site. All investigators and participants were masked to treatment assignment. Participants were followed up at least every 6 months for incident cardiovascular and other serious clinical outcomes. The primary outcome was the first occurrence of the composite endpoint of non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes (including unknown causes), which was assessed in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT01394952.Findings Between Aug 18, 2011, and Aug 14, 2013, 9901 participants (mean age 66.2 years [SD 6.5], median HbA 1c 7.2% [IQR 6.6-8.1], 4589 [46.3%] women) were enrolled and randomly assigned to receive dulaglutide (n=4949) or placebo (n=4952). During a median follow-up of 5.4 years (IQR 5.1-5.9), the primary composite outcome occurred in 594 (12.0%) participants at an incidence rate of 2.4 per 100 person-years in the dulaglutide group and in 663 (13.4%) participants at an incidence rate of 2.7 per 100 person-years in the placebo group (hazard ratio [HR] 0.88, 95% CI 0.79-0.99; p=0.026). All-cause mortality did not differ between groups (536 [10.8%] in the dulaglutide group vs 592 [12.0%] in the placebo group; HR 0.90, 95% CI 0.80-1.01; p=0.067). 2347 (47.4%) participants assigned to dulaglutide reported a gastrointestinal adverse event during follow-up compared with 1687 (34.1%) participants assigned to placebo (p< 0.0001).Interpretation Dulaglutide could be considered for the management of glycaemic control in middle-aged and older people with type 2 diabetes with either previous cardiovascular disease or cardiovascular risk factors. Copyright (c) 2019 Elsevier Ltd. 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true A nemzetközi false true MtaRating 519059 /api/mtarating/519059 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19059 true SjrRating 10990195 /api/sjrrating/10990195 6 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/31083813 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Gerstein Hertzel C. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002738"><a href="/gui2/?type=authors&mode=browse&sel=10002738" target="_blank">Keltai Matyas (<span class="authorship-author-name">Keltai Mátyás</span> <span class="authorAux-mtmt"> Klinikai kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (37) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10023829"><a href="/gui2/?type=authors&mode=browse&sel=10023829" target="_blank">Keltai Katalin (<span class="authorship-author-name">Keltai Katalin</span> <span class="authorAux-mtmt"> Kardiológia, belgyógyászat</span>) </a> </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">REWIND Investigator</span> </div> <div><a target="_blank" href="/api/publication/31083813?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31083813" target="_blank">Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial</a></div> <div> <span class="journal-title">LANCET</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0140-6736">0140-6736</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-547X">1474-547X</a>)</span>: <span class="journal-volume">394</span> <span class="journal-issue">10193</span> <span class="page"> pp 121-130 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S0140-6736(19)31149-3" target="_blank" href="https://doi.org/10.1016/S0140-6736%2819%2931149-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000475393900025" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000475393900025"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85068151338" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85068151338"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31189511" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31189511&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Demográfiai Osztályközi Állandó Bizottság IXGJO DEM [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2,509</span> | Független: 2,429 | Függő: 80 | Nem jelölt: 0 | WoS jelölt: 2,274 | Scopus jelölt:&nbsp;2,356 | WoS/Scopus jelölt:&nbsp;2,508 | DOI jelölt:&nbsp;2,426 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31083813&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31083813</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.03.21. 12:08 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Eli Lilly and CompanyEli Lilly; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30CA008748] Funding Source: NIH RePORTER Funding text: Eli Lilly and Company.</pre> </div></div>