https://m2.mtmt.hu/ hun 2026-09-23 02:34 JournalArticle 31072777 VALIDATED true 0 false 2026-09-15T10:52:54.964+0000 2024-11-29T08:57:42.015+0000 2020-01-09T17:44:36.536+0000 true 565 WoS import /api/admin/565 Admin true 2024-11-29T08:00:48.639+0000 2024-11-29T08:00:48.639+0000 2024-11-29T08:57:42.625+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Ray, K.K. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial true true /api/journal/10028839 REVIEWED true false 10028839 false 10028839 true 2213-8587 2213-8595 Journal FOREIGN 7 8 618 628 618 11 2019 Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1.4-1.8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes.Methods ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1-12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1: 1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0.65-1.30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)-defined on the basis of patient history, review of medical records, or baseline HbA(1c) or fasting serum glucose-and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. ODYSSEY OUTCOMES is registered with ClinicalTrials. gov, number NCT01663402.Findings At study baseline, 5444 patients (28.8%) had diabetes, 8246 (43.6%) had prediabetes, and 5234 (27.7%) had normoglycaemia. There were no significant differences across glycaemic categories in median LDL cholesterol at baseline (2.20-2.28 mmol/L), after 4 months' treatment with alirocumab (0.80 mmol/L), or after 4 months' treatment with placebo (2.25-2.28 mmol/L). In the placebo group, the incidence of the primary endpoint over a median of 2.8 years was greater in patients with diabetes (16.4%) than in those with prediabetes (9.2%) or normoglycaemia (8.5%); hazard ratio (HR) for diabetes versus normoglycaemia 2.09 (95% CI 1.78-2.46, p<0.0001) and for diabetes versus prediabetes 1.90 (1.65-2.17, p<0.0001). Alirocumab resulted in similar relative reductions in the incidence of the primary endpoint in each glycaemic category, but a greater absolute reduction in the incidence of the primary endpoint in patients with diabetes (2.3%, 95% CI 0.4 to 4.2) than in those with prediabetes (1.2%, 0.0 to 2.4) or normoglycaemia (1.2%, -0.3 to 2.7; absolute risk reduction p(interaction) = 0.0019). Among patients without diabetes at baseline, 676 (10.1%) developed diabetes in the placebo group, compared with 648 (9.6%) in the alirocumab group; alirocumab did not increase the risk of new-onset diabetes (HR 1.00, 95% CI 0.89-1.11). HRs were 0.97 (95% CI 0.87-1.09) for patients with prediabetes and 1.30 (95% CI 0.93-1.81) for those with normoglycaemia (p(interaction) = 0.11).Interpretation After a recent acute coronary syndrome, alirocumab treatment targeting an LDL cholesterol concentration of 0.65-1.30 mmol/L produced about twice the absolute reduction in cardiovascular events among patients with diabetes as in those without diabetes. Alirocumab treatment did not increase the risk of new-onset diabetes. Copyright (C) 2019 Elsevier Ltd. All rights reserved. true true 2020 true true true false true false GREEN 2026-09-15 true http://publicatio.bibl.u-szeged.hu/23453 377 0 372 322 4 367 341 335 302 377 372 327 322 327 50 0 377 327 372 322 0 4 4 Folyóiratcikk Journal Article 24 355 Könyvrészlet Chapter in Book 25 10 Könyv Book 23 7 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 5 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 18 12 18 12 2020 0 62 42 62 42 2021 0 78 71 78 71 2022 0 38 35 38 35 2023 0 51 49 51 49 2024 0 67 60 67 60 2025 0 54 51 54 51 2026 0 9 7 9 7 D1 false false false false 2021-04-03T22:34:54.553+0000 II. sz. Belgyógyászati Klinika és Kardiológiai ... 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IDENTICAL 31272931 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31272931&dopt=Abstract true true PublicationIdentifier 20480183 /api/publicationidentifier/20480183 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 23453 http://publicatio.bibl.u-szeged.hu/23453 false true Classification 12215 /api/classification/12215 true true Classification 12124 /api/classification/12124 true true Classification 12221 /api/classification/12221 true true SjrRating 10796493 /api/sjrrating/10796493 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true D1 DIRECT true true /api/publication/31072777 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Ray K.K. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Colhoun H.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szarek M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Baccara-Dinet M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhatt D.L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bittner V.A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Budaj A.J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Diaz R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goodman S.G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hanotin C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harrington R.A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jukema J.W. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Loizeau V. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lopes R.D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moryusef A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Murin J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pordy R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ristic A.D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Roe M.T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tuñón J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >White H.D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zeiher A.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwartz G.G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Steg P. G. </span> </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" >Tibor Turi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Bela Merkely (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062147"><a href="/gui2/?type=authors&mode=browse&sel=10062147" target="_blank">Imre Ungi (<span class="authorship-author-name">Ungi Imre</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Kardiológiai Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Geza Lupkovics </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lajos Nagy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059927"><a href="/gui2/?type=authors&mode=browse&sel=10059927" target="_blank">András Katona (<span class="authorship-author-name">Katona András</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Kardiológiai Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >István Édes </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gábor Müller </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014594"><a href="/gui2/?type=authors&mode=browse&sel=10014594" target="_blank">Iván Horvath (<span class="authorship-author-name">Horváth Iván</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/Általános Orvostudományi Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tibor Kapin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zsolt Szigeti </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >József Faluközy </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">ODYSSEY OUTCOMES Committees Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31072777" target="_blank">Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial</a></div> <div> <span class="journal-title">LANCET DIABETES & ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2213-8587">2213-8587</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2213-8595">2213-8595</a>)</span>: <span class="journal-volume">7</span> <span class="journal-issue">8</span> <span class="page"> pp 618-628 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S2213-8587(19)30158-5" target="_blank" href="https://doi.org/10.1016/S2213-8587%2819%2930158-5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000475553300016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000475553300016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85068931122" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85068931122"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31272931" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31272931&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="23453" target="_blank" href="http://publicatio.bibl.u-szeged.hu/23453"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 377</span> | Független: 327 | Függő: 50 | Nem jelölt: 0 | WoS jelölt: 335 | Scopus jelölt:&nbsp;302 | WoS/Scopus jelölt:&nbsp;377 | DOI jelölt:&nbsp;341 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31072777&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31072777</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2024.11.29. 09:57 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>