Mechanochemical Synthesis, in vitro Evaluation and Molecular Docking Studies of 4-Amino-2-arylamino-5-(benzofuran-2-oyl)thiazoles as Antidiabetic Agents

Akhila, Vijayan R.; Priya, Maheswari R.; Sherin, Daisy R.; Krishnapriya, Girija K.; Keerthi, Sreerekha V.; Manojkumar, Thanathu K.; Rajasekharan, Kallikat N. ✉

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: LETTERS IN ORGANIC CHEMISTRY 1570-1786 16 (7) pp. 560-568 2019
  • SJR Scopus - Biochemistry: Q4
Azonosítók
Szakterületek:
    The synthesis of 4-amino-2-arylamino-5-(benzofuran-2-oyl)thiazoles 4a-h, as example of 2,4-diaminothiazole-benzofuran hybrids and an evaluation of their antidiabetic activity, by in vitro and computational methods, are reported. The synthesis of these diaminothiazoles was achieved mechano chemically by a rapid solvent-less method. Their antidiabetic activity was assessed by alpha-glucosidase and alpha-amylase inhibition assays. The, IC50 value for alpha-glucosidase inhibition by 4-amino-5-(benzofuran-2-oyl)-2-(4-methoxyphenylamino)thiazole (4d) was found to be 20.04 mu M and the IC50 value for alpha-amylase inhibition, 195.03 mu M whereas the corresponding values for reference acarbose were 53.38 mu M and 502.03 mu M, respectively. Molecular docking studies at the active sites of alpha-glucosidase and alpha-amylase showed that among the diaminothiazoles 4a-h now studied, 4-amino-5-(benzofuran-2-oyl)-2-(4-methoxyphenylamino)thiazole (4d) has the highest D-scores of -8.63 and -8.08 for alpha-glucosidase and for alpha-amylase, with binding energies -47.76 and -19.73 kcal/mol, respectively.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-01-19 09:44