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Clinical progress was monitored by the Multiple organ dysfunction score, systemic inflammatory response by serum procalcitonin (PCT), C-reactive protein (CRP) and microalbuminuria during the first 3 postoperative days. Mann-Whitney and chi 2 tests were used for statistical analysis.\n\nRESULTS:\nThere was no significant difference between the two groups regarding the MODS, organ dysfunction, length of intensive care stay, days of mechanical ventilation and mortality. PCT and microalbuminuria did not differ significantly. Significantly lower CRP levels were found in the NAC group on day one and two [t24: median: 84.5 interquartile range: (62.48-120.25) vs. 118 (86-137) mg/l; p = 0.020; t48: 136 (103-232) vs. 195 (154.5-252) mg/l p = 0.013, NAC vs. placebo].\n\nCONCLUSION:\nThe results of this study do not support the routine use of NAC as a prophylactic drug during surgery, and reinforce previous evidence which challenge the indication of NAC in the critically ill patient.", "subjects" : [ { "otype" : "Classification", "mtid" : 10580, "link" : "/api/classification/10580", "label" : "Anyagcsere", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12249, "link" : "/api/classification/12249", "label" : "Intenzív ellátás", "published" : true, "snippet" : true } ], "digital" : null, "printed" : true, "sourceYear" : 2020, "foreignEdition" : false, "foreignLanguage" : false, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, 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