https://m2.mtmt.hu/hun2024-03-28 13:53JournalArticle31023490ADMIN_APPROVEDtrueDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, Netherlands
Department of Applied Mathematics and Technical Medical Centre, University of Twente, Enschede, Netherlands
Cited By :1
Export Date: 18 August 2020
CODEN: EJONE
Correspondence Address: Hebbink, J.; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre UtrechtNetherlands; email: g.j.hebbink@utwente.nl0false2022-11-18T11:14:12.735+00002021-12-01T12:16:34.227+00002019-12-22T09:17:35.362+0000true565WoSimport
/api/admin/565
Admintrue2024-01-29T07:33:49.337+00002021-12-01T12:16:34.237+0000true10044649TomcsányiZsuzsanna
/api/admin/10044649
Admintrue10044649falsefalsetrue2424
/api/publicationtype/24
PublicationType1true24JournalArticletrue10000059Articletrue2424
/api/publicationtype/24
PublicationType1true24JournalArticle
/api/subtype/10000059
SzakcikkSubType101true10000059true1
/api/category/1
Categorytrue1Hebbink, JurgenPathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibitiontruetrue
/api/journal/1510
REVIEWEDtruefalse1510false1510true0953-816X1460-9568JournalFOREIGN514112211361122152020Delineation of epileptogenic cortex in focal epilepsy patients may profit from single-pulse electrical stimulation during intracranial EEG recordings. Single-pulse electrical stimulation evokes early and delayed responses. Early responses represent connectivity. Delayed responses are a biomarker for epileptogenic cortex, but up till now, the precise mechanism generating delayed responses remains elusive. We used a data-driven modelling approach to study early and delayed responses. We hypothesized that delayed responses represent indirect responses triggered by early response activity and investigated this for 11 patients. Using two coupled neural masses, we modelled early and delayed responses by combining simulations and bifurcation analysis. An important feature of the model is the inclusion of feedforward inhibitory connections. The waveform of early responses can be explained by feedforward inhibition. Delayed responses can be viewed as second-order responses in the early response network which appear when input to a neural mass falls below a threshold forcing it temporarily to a spiking state. The combination of the threshold with noisy background input explains the typical stochastic appearance of delayed responses. The intrinsic excitability of a neural mass and the strength of its input influence the probability at which delayed responses to occur. Our work gives a theoretical basis for the use of delayed responses as a biomarker for the epileptogenic zone, confirming earlier clinical observations. The combination of early responses revealing effective connectivity, and delayed responses showing intrinsic excitability, makes single-pulse electrical stimulation an interesting tool to obtain data for computational models of epilepsy surgery.2019truetruetruefalsefalsefalseNONE2022-11-18false00000000000022Q2falsefalsefalsefalse2021-11-30T12:16:33.981+0000645050trueLanguage10002
/api/language/10002
AngolEnglishtrue2truePersonAuthorship89671382
/api/authorship/89671382
10.0truefalsetrueHebbinkJurgentruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship89671383
/api/authorship/89671383
20.0falsefalsefalseHuiskampGeertjantruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship89671384
/api/authorship/89671384
30.0falsefalsefalsevan GilsStephan A.truefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship89671385
/api/authorship/89671385
40.0falsefalsefalseLeijtenFrans S. S.truefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship89671386
/api/authorship/89671386
50.0falsetruefalseMeijerHil G. E.truefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePublicationIdentifier16323495
/api/publicationidentifier/16323495
IDENTICAL10.1111/ejn.14562https://doi.org/10.1111/ejn.14562falsetruePublicationIdentifier16323494
/api/publicationidentifier/16323494
IDENTICAL000487412200001https://www.webofscience.com/wos/woscc/full-record/WOS:000487412200001falsetruePublicationIdentifier17123703
/api/publicationidentifier/17123703
IDENTICAL85073829414http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85073829414falsetruePublicationIdentifier17123716
/api/publicationidentifier/17123716
IDENTICAL31454445http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31454445&dopt=AbstractfalsetrueClassification12125
/api/classification/12125
truetrueKeyword1041660
/api/keyword/1041660
true1041660trueKeyword1519183
/api/keyword/1519183
truetrueKeyword1871031
/api/keyword/1871031
truetrueKeyword1872183
/api/keyword/1872183
truetrueKeyword1872184
/api/keyword/1872184
truetrueSjrRating10862761
/api/sjrrating/10862761
420.49journalRatingType10002
/api/ratingtype/10002
sjrtruetrueClassificationExternal2801
/api/classificationexternal/2801
true2801trueQ2DIRECTtruetrue
/api/publication/31023490
<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Hebbink, Jurgen ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Huiskamp, Geertjan </span> <span class="author-type"> </span> ; <span class="author-name" > van Gils, Stephan A. </span> <span class="author-type"> </span> ; <span class="author-name" > Leijten, Frans S. S. </span> <span class="author-type"> </span> ; <span class="author-name" > Meijer, Hil G. E. </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31023490" mtid="31023490" target="_blank">Pathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibition</a></div> <div class="pub-info"> <span class="journal-title">EUROPEAN JOURNAL OF NEUROSCIENCE</span> <span class="journal-volume">51</span> : <span class="journal-issue">4</span> <span class="page"> pp. 1122-1136. , 15 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/ejn.14562" target="_blank" href="https://doi.org/10.1111/ejn.14562"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000487412200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000487412200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85073829414" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85073829414"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31454445" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31454445&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:31023490 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Hebbink Jurgen ✉
</span>
;
<span class="author-name" >Huiskamp Geertjan
</span>
;
<span class="author-name" >van Gils Stephan A.
</span>
;
<span class="author-name" >Leijten Frans S. S.
</span>
;
<span class="author-name" >Meijer Hil G. E.
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;31023490" target="_blank">Pathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibition</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF NEUROSCIENCE</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0953-816X">0953-816X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-9568">1460-9568</a>)</span>:
<span class="journal-volume">51</span> <span class="journal-issue">4</span>
<span class="page">
pp 1122-1136
</span> <span class="year">(2020)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
Angol
| </span>
<span class="identifiers">
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="10.1111/ejn.14562" target="_blank" href="https://doi.org/10.1111/ejn.14562">
DOI
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="000487412200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000487412200001">
WoS
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="85073829414" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85073829414">
Scopus
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="31454445" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31454445&dopt=Abstract">
PubMed
</a>
</span>
</span>
<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;31023490&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 2
</a>
</div>
<div class="mtid"><span class="long-pub-mtid">Közlemény: 31023490</span>
| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
</span>
Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">WoS-XML</span>
</div>
<div class="lastModified">Utolsó módosítás: 2021.12.01. 13:16 Tomcsányi Zsuzsanna (MTMT_KP_admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, Netherlands
Department of Applied Mathematics and Technical Medical Centre, University of Twente, Enschede, Netherlands
Cited By :1
Export Date: 18 August 2020
CODEN: EJONE
...</pre>
</div></div>