https://m2.mtmt.hu/ eng 2026-10-24 15:13 JournalArticle 3101852 APPROVED true MTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Neurosurgery, University of Szeged, Szeged, Hungary Cited By :64 Export Date: 6 March 2025 Correspondence Address: Tamás, G.; MTA-SZTE Research Group for Cortical Microcircuits, Hungary; email: gtamas@bio.u-szeged.hu Funding details: European Commission, EC Funding details: Seventh Framework Programme, FP7, 293681 0 2018-02-20T17:09:33.000+0000 false 3101852 2026-10-19T11:24:02.735+0000 2025-03-03T10:20:10.231+0000 2016-08-19T10:33:42.000+0000 true 10000499 Nusser Zoltán /api/author/10000499 Author true 10000499 2025-03-17T08:33:16.323+0000 2025-03-17T08:33:16.323+0000 2019-05-29T11:03:15.250+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2021-10-28T10:51:40.461+0000 true 10073049 Sóki Edina /api/admin/10073049 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Molnar, G Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 5 e18167 e18167 12 2016 Classic theories link cognitive abilities to synaptic properties and human-specific biophysical features of synapses might contribute to the unparalleled performance of the human cerebral cortex. Paired recordings and multiple probability fluctuation analysis revealed similar quantal sizes, but 4-times more functional release sites in human pyramidal cell to fast-spiking interneuron connections compared to rats. These connections were mediated on average by three synaptic contacts in both species. Each presynaptic active zone (AZ) contains 6.2 release sites in human, but only 1.6 in rats. Electron microscopy (EM) and EM tomography showed that an AZ harbors 4 docked vesicles in human, but only a single one in rats. Consequently, a Katz's functional release site occupies ~0.012 mum2 in the human presynaptic AZ and ~0.025 mum2 in the rat. Our results reveal a robust difference in the biophysical properties of a well-defined synaptic connection of the cortical microcircuit of human and rodents. 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http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN false IDENTICAL 9716 http://publicatio.bibl.u-szeged.hu/9716 false 1467093 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12258 /api/classification/12258 true true Classification 12215 /api/classification/12215 true true SjrRating 10946621 /api/sjrrating/10946621 21 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/3101852 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10019065"><a href="/gui2/?type=authors&mode=browse&sel=10019065" target="_blank">Molnar G (<span class="authorship-author-name">Molnár Gábor</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/<span title="Department of Physiology, Anatomy and Neuroscience">ÉSZIT</span>/MTA-SZTE Research Group for Cortical Microcircuits</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049033"><a href="/gui2/?type=authors&mode=browse&sel=10049033" target="_blank">Rozsa M<sup>*</sup> (<span class="authorship-author-name">Rózsa Márton</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/<span title="Department of Physiology, Anatomy and Neuroscience">ÉSZIT</span>/MTA-SZTE Research Group for Cortical Microcircuits</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038198"><a href="/gui2/?type=authors&mode=browse&sel=10038198" target="_blank">Baka J (<span class="authorship-author-name">Baka Judith</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/<span title="Department of Physiology, Anatomy and Neuroscience">ÉSZIT</span>/MTA-SZTE Research Group for Cortical Microcircuits</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011496"><a href="/gui2/?type=authors&mode=browse&sel=10011496" target="_blank">Holderith N (<span class="authorship-author-name">Holderith Noémi</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003396"><a href="/gui2/?type=authors&mode=browse&sel=10003396" target="_blank">Barzo P (<span class="authorship-author-name">Barzó Pál</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Neurosurgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000392"><a href="/gui2/?type=authors&mode=browse&sel=10000392" target="_blank">Tamas G ✉ (<span class="authorship-author-name">Tamás Gábor</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/<span title="Department of Physiology, Anatomy and Neuroscience">ÉSZIT</span>/MTA-SZTE Research Group for Cortical Microcircuits</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3101852" target="_blank">Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">5</span> <span class="page"> Paper e18167. 12 p. </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.18167" target="_blank" href="https://doi.org/10.7554/eLife.18167"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000383808600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000383808600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84983591473" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84983591473"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27536876" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27536876&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="9716" target="_blank" href="http://publicatio.bibl.u-szeged.hu/9716"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 89</span> | Independent citation: 77 | Self citation: 12 | Unknown citation: 0 | Number of citations in WoS: 85 | Number of citations in Scopus:&nbsp;79 | WoS/Scopus assigned:&nbsp;89 | Number of citations with DOI:&nbsp;89 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3101852&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3101852</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 3101852</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Seventh Framework Programme(FP7, 293681) </div> <div class="lastModified">Last Modified: 2025.03.03. 11:20 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: MTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Neurosurgery, University of Szeged, Szeged, Hungary Cited By :64 ...</pre> </div></div>