https://m2.mtmt.hu/ eng 2026-06-24 00:38 JournalArticle 31009490 VALIDATED true Cited By :16 Export Date: 20 September 2022 0 false 2026-06-15T07:07:16.922+0000 2025-03-28T12:51:24.765+0000 2019-12-16T10:01:40.842+0000 true 10000223 Hamar Péter /api/author/10000223 Author true 10000223 2026-06-15T07:05:40.518+0000 2026-06-15T07:05:40.518+0000 2025-03-28T12:51:25.227+0000 true 10097129 Vékony-Pap Lili /api/admin/10097129 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szűcs, Gergő Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac Lipidome and Proteome and Leads to Deterioration of Cardiac Function prior to the Development of Excessive Oxidative Stress and Cell Damage true true /api/journal/10011773 REVIEWED true false 10011773 false 10011773 true 1942-0900 1942-0994 Journal FOREIGN 2019 3218275 3218275 21 2019 Prediabetes is a condition affecting more than 35% of the population. In some forms, excessive carbohydrate intake (primarily refined sugar) plays a prominent role. Prediabetes is a symptomless, mostly unrecognized disease which increases cardiovascular risk. In our work, we examined the effect of a fructose-enriched diet on cardiac function and lipidome as well as proteome of cardiac muscle. Male Wistar rats were divided into two groups. The control group received a normal diet while the fructose-fed group received 60% fructose-supplemented chow for 24 weeks. Fasting blood glucose measurement and oral glucose tolerance test (OGTT) showed slightly but significantly elevated values due to fructose feeding indicating development of a prediabetic condition. Both echocardiography and isolated working heart perfusion performed at the end of the feeding protocol demonstrated diastolic cardiac dysfunction in the fructose-fed group. Mass spectrometry-based, high-performance lipidomic and proteomic analyses were executed from cardiac tissue. The lipidomic analysis revealed complex rearrangement of the whole lipidome with special emphasis on defects in cardiolipin remodeling. The proteomic analysis showed significant changes in 75 cardiac proteins due to fructose feeding including mitochondria-, apoptosis-, and oxidative stress-related proteins. Nevertheless, just very weak or no signs of apoptosis induction and oxidative stress were detected in the hearts of fructose-fed rats. Our results suggest that fructose feeding induces marked alterations in the cardiac lipidome, especially in cardiolipin remodeling, which leads to mitochondrial dysfunction and impaired cardiac function. However, at the same time, several adaptive responses are induced at the proteome level in order to maintain a homeostatic balance. These findings demonstrate that even very early stages of prediabetes can impair cardiac function and can result in significant changes in the lipidome and proteome of the heart prior to the development of excessive oxidative stress and cell damage. 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/api/publication/31009490 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027528"><a href="/gui2/?type=authors&mode=browse&sel=10027528" target="_blank">Szűcs Gergő ✉ (<span class="authorship-author-name">Szűcs Gergő</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055941"><a href="/gui2/?type=authors&mode=browse&sel=10055941" target="_blank">Sója Andrea<sup>*</sup> (<span class="authorship-author-name">Apjok-Sója Andrea</span> <span class="authorAux-mtmt"> Metabolikus betegségek szívhatásai</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025206"><a href="/gui2/?type=authors&mode=browse&sel=10025206" target="_blank">Péter Mária<sup>*</sup> (<span class="authorship-author-name">Péter Mária</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028929"><a href="/gui2/?type=authors&mode=browse&sel=10028929" target="_blank">Sárközy Márta (<span class="authorship-author-name">Sárközy Márta</span> <span class="authorAux-mtmt"> Elméleti orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055010"><a href="/gui2/?type=authors&mode=browse&sel=10055010" target="_blank">Bruszel Bella (<span class="authorship-author-name">Bruszel Bella</span> <span class="authorAux-mtmt"> Analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Medical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028747"><a href="/gui2/?type=authors&mode=browse&sel=10028747" target="_blank">Siska Andrea (<span class="authorship-author-name">Siska Andrea</span> <span class="authorAux-mtmt"> klinikai kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Laboratory Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029238"><a href="/gui2/?type=authors&mode=browse&sel=10029238" target="_blank">Földesi Imre (<span class="authorship-author-name">Földesi Imre</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Laboratory Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027486"><a href="/gui2/?type=authors&mode=browse&sel=10027486" target="_blank">Szabó Zoltán (<span class="authorship-author-name">Szabó Zoltán</span> <span class="authorAux-mtmt"> proteomika</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Medical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008620"><a href="/gui2/?type=authors&mode=browse&sel=10008620" target="_blank">Janáky Tamás (<span class="authorship-author-name">Janáky Tamás</span> <span class="authorAux-mtmt"> Kémiai analitika</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Medical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1035720"><a href="/gui2/?type=authors&mode=browse&sel=1035720" target="_blank">Vígh László (<span class="authorship-author-name">Vigh László</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024899"><a href="/gui2/?type=authors&mode=browse&sel=10024899" target="_blank">Balogh Gábor<sup>**</sup> (<span class="authorship-author-name">Balogh Gábor</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Biochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028282"><a href="/gui2/?type=authors&mode=browse&sel=10028282" target="_blank">Csont Tamás ✉ (<span class="authorship-author-name">Csont Tamás Bálint</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Biochemistry</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31009490" target="_blank">Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac Lipidome and Proteome and Leads to Deterioration of Cardiac Function prior to the Development of Excessive Oxidative Stress and Cell Damage</a></div> <div> <span class="journal-title">OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0900">1942-0900</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0994">1942-0994</a>)</span>: <span class="journal-volume">2019</span> <span class="page"> Paper 3218275. 21 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2019/3218275" target="_blank" href="https://doi.org/10.1155/2019/3218275"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000504219500002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000504219500002"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="114245" target="_blank" href="https://real.mtak.hu/114245"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85077314070" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85077314070"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31885782" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31885782&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="18653" target="_blank" href="http://publicatio.bibl.u-szeged.hu/18653"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 41</span> | Independent citation: 32 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 39 | Number of citations in Scopus:&nbsp;29 | WoS/Scopus assigned:&nbsp;40 | Number of citations with DOI:&nbsp;39 (Not published:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31009490&sort=publishedYear,desc&sort=title"> Number of cited publications: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 31009490</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Funder: NRDIO </div> <div class="notDuplums"><a target="_blank" href="/api/publication/31009490/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2025.03.28. 13:51 Lili Vékony-Pap (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :16 Export Date: 20 September 2022</pre> </div></div>