https://m2.mtmt.hu/ hun 2026-09-21 10:32 JournalArticle 30998952 VALIDATED true Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, México City, Mexico Biostatistics Consultant, Minot, United States Department of Neurology, University of PennsylvaniaPA, United States Institute for Neurological Research FLENI, Buenos Aires, Argentina Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy Department of Neurology, Semmelweis University, Budapest, Hungary Neurology Department, Hospital Juárez, México City, Mexico Department of Neurology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran, Mexico City, Mexico Department of Neurology, Institute Psychiatry and Neurology, Warsaw, Poland Department of Neurology, Sigmund Freud University Vienna, Medical Faculty and Hospital St. John of God, Beaconsfield, Australia Bayer U.S., LLC, Whippany, NJ, United States Bayer AG, Wuppertal, Germany Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada Export Date: 11 October 2022 Correspondence Address: Arauz, A.; Stroke Clinic, Mexico; email: antonio.arauz@prodigy.net.mx 0 false 2026-05-19T15:08:30.771+0000 2026-04-09T11:42:13.552+0000 2019-12-12T18:10:18.652+0000 true 10013822 WoS admin-2 -1 /api/admin/10013822 Admin true 10013822 2026-04-09T11:42:13.113+0000 2022-04-06T11:14:44.990+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Arauz, Antonio Regional, sex, and age differences in diagnostic testing among participants in the NAVIGATE-ESUS trial true true /api/journal/2152190 REVIEWED true false 2152190 false 2152190 true 1747-4930 1747-4949 Journal FOREIGN 16 1 55 62 55 8 2021 Background and aim The diagnosis of embolic stroke of undetermined source (ESUS) is based on excluding other more likely stroke etiologies, and therefore diagnostic testing plays an especially crucial role. Our objective was to compare the diagnostic testing by region, sex, and age among the participants of NAVIGATE-ESUS trial.Methods Participants were grouped according to five global regions (North America, Latin America, Western Europe, Eastern Europe and East Asia), age (<60, 60-74, and >75 years), and sex. Frequencies of each diagnostic test within areas of echocardiography, cardiac rhythm monitoring, and arterial imaging were described and compared across groups. A multivariable logistic regression model for each diagnostic test was fit to assess the independent influence of each of region, age, and sex and likelihood of testing. Results We included 6985 patients in the analysis (918 from North America; 746 from Latin America; 2853 from Western Europe; 1118 from Eastern Europe; 1350 from East Asia). Average age (highest in Western Europe (69 years), lowest in Eastern Europe (65 years)), % females (highest in Latin America (44%) and lowest in East Asia (31%)), and use of each diagnostic test varied significantly across regions. Region, but not sex, was independently associated with use of each diagnostic test examined. Transesophageal echocardiography and either CT or MR angiogram were more often used in younger patients. Conclusion Diagnostic testing differed by region, and less frequently by age, but not by sex. Our findings reflect the existing variations in global practice in diagnostic testing in ESUS patients. true true 2019 true true true false true false NONE 2026-05-19 false 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 D1 false false false false 2020-01-07T10:46:11.356+0000 Neurológiai Klinika (SE / AOK / K) 1 10 1 15 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 89432435 /api/authorship/89432435 1 0.06666667 true false true Arauz Antonio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432436 /api/authorship/89432436 2 0.06666667 false false false Serrano Fabiola true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432437 /api/authorship/89432437 3 0.06666667 false false false Pearce Lesly A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432438 /api/authorship/89432438 4 0.06666667 false false false Kasner Scott E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432439 /api/authorship/89432439 5 0.06666667 false false false Ameriso Sebastian F. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432440 /api/authorship/89432440 6 0.06666667 false false false Toni Danilo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432441 /api/authorship/89432441 7 0.06666667 false false false Author 10000800 /api/author/10000800 Bereczki Dániel true 10000800 true Bereczki Daniel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432442 /api/authorship/89432442 8 0.06666667 false false false Siegler James true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432443 /api/authorship/89432443 9 0.06666667 false false false Ruiz-Franco Angelica true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432444 /api/authorship/89432444 10 0.06666667 false false false Cantu-Brito Carlos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432445 /api/authorship/89432445 11 0.06666667 false false false Czlonkowska Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432446 /api/authorship/89432446 12 0.06666667 false false false Lang Wilfried true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432447 /api/authorship/89432447 13 0.06666667 false false false Berkowitz Scott D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432448 /api/authorship/89432448 14 0.06666667 false false false Mundl Hardi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89432449 /api/authorship/89432449 15 0.06666667 false true false Hart Robert G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16273198 /api/publicationidentifier/16273198 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1177/1747493019884523 https://doi.org/10.1177/1747493019884523 false true PublicationIdentifier 16273197 /api/publicationidentifier/16273197 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000491727400001 https://www.webofscience.com/wos/woscc/full-record/000491727400001 false true PublicationIdentifier 16574044 /api/publicationidentifier/16574044 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85074582364 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074582364 false true PublicationIdentifier 16357964 /api/publicationidentifier/16357964 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31631796 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31631796&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Keyword 437 /api/keyword/437 true 437 true Keyword 579 /api/keyword/579 true 579 true Keyword 2085 /api/keyword/2085 true 2085 true Keyword 1511445 /api/keyword/1511445 true true SjrRating 11236533 /api/sjrrating/11236533 17 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2808 /api/classificationexternal/2808 true 2808 true D1 DIRECT true true /api/publication/30998952 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Arauz Antonio ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Serrano Fabiola </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pearce Lesly A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kasner Scott E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ameriso Sebastian F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Toni Danilo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000800"><a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki Daniel (<span class="authorship-author-name">Bereczki Dániel</span> <span class="authorAux-mtmt"> Stroke</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Siegler James </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ruiz-Franco Angelica </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cantu-Brito Carlos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Czlonkowska Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lang Wilfried </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Berkowitz Scott D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mundl Hardi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hart Robert G. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30998952" target="_blank">Regional, sex, and age differences in diagnostic testing among participants in the NAVIGATE-ESUS trial</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF STROKE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1747-4930">1747-4930</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1747-4949">1747-4949</a>)</span>: <span class="journal-volume">16</span> <span class="journal-issue">1</span> <span class="page"> pp 55-62 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1177/1747493019884523" target="_blank" href="https://doi.org/10.1177/1747493019884523"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000491727400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000491727400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074582364" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074582364"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31631796" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31631796&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30998952&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30998952</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.09. 13:42 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez, México City, Mexico Biostatistics Consultant, Minot, United States Department of Neurology, University of PennsylvaniaPA, United States Institute for Neurological Research FLENI, Buenos Aires, Argentina Department o...</pre> </div></div>