{ "labelLang" : "eng", "responseDate" : "2024-03-28 16:35", "content" : { "otype" : "JournalArticle", "mtid" : 30997153, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: Slovak Research and Development AgencySlovak Research and Development Agency [APVV-14-0032]\n Funding text: This research was funded by Slovak Research and Development Agency, grant number APVV-14-0032.", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-10-11T13:31:54.823+0000", "lastModified" : "2019-12-12T16:26:35.802+0000", "created" : "2019-12-12T16:26:34.915+0000", "creator" : { "otype" : "Admin", "mtid" : 10013822, "link" : "/api/admin/10013822", "label" : "-1 WoS admin-2 (WoS import 3, admin)", "familyName" : "WoS admin-2", "givenName" : "-1", "published" : true, "oldId" : 10013822, "snippet" : true }, "lastDuplumSearch" : "2023-11-14T15:59:49.792+0000", "validated" : "2019-12-12T16:26:35.042+0000", "validator" : { "otype" : "Admin", "mtid" : 10013822, "link" : "/api/admin/10013822", "label" : "-1 WoS admin-2 (WoS import 3, admin)", "familyName" : "WoS admin-2", "givenName" : "-1", "published" : true, "oldId" : 10013822, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Journal Article", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 1134514, "link" : "/api/subtype/1134514", "label" : "Survey paper (Journal Article)", "name" : "Összefoglaló cikk", "nameEng" : "Survey paper", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Journal Article", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 102, "published" : true, "oldId" : 1134514, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Scientific", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "English", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Csobonyeiova, Maria", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 89419456, "link" : "/api/authorship/89419456", "label" : "Csobonyeiova, Maria", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Csobonyeiova", "givenName" : "Maria", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89419457, "link" : "/api/authorship/89419457", "label" : "Polak, Stefan", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Polak", "givenName" : "Stefan", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89419458, "link" : "/api/authorship/89419458", "label" : "Zamborsky, Radoslav", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Zamborsky", "givenName" : "Radoslav", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89419459, "link" : "/api/authorship/89419459", "label" : "Danisovic, Lubos ✉", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Danisovic", "givenName" : "Lubos", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Author", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Recent Progress in the Regeneration of Spinal Cord Injuries by Induced Pluripotent Stem Cells", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 16269438, "link" : "/api/publicationidentifier/16269438", "label" : "DOI: 10.3390/ijms20153838", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.3390/ijms20153838", "realUrl" : "https://doi.org/10.3390%2Fijms20153838", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16269437, "link" : "/api/publicationidentifier/16269437", "label" : "WoS: 000482383000231", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/WOS:@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000482383000231", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/WOS:000482383000231", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 21789089, "link" : "/api/publicationidentifier/21789089", "label" : "Scopus: 85071281784", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85071281784", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85071281784", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 18456685, "link" : "/api/publicationidentifier/18456685", "label" : "PubMed: 31390782", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "31390782", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31390782&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10003252, "link" : "/api/journal/10003252", "label" : "INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067", "pIssn" : "1661-6596", "eIssn" : "1422-0067", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10003252, "snippet" : true }, "volume" : "20", "issue" : "15", "internalId" : "3838", "firstPageOrInternalIdForSort" : "3838", "pageLength" : 13, "publishedYear" : 2019, "abstractText" : "Regeneration of injuries occurring in the central nervous system, particularly spinal cord injuries (SCIs), is extremely difficult. The complex pathological events following a SCI often restrict regeneration of nervous tissue at the injury site and frequently lead to irreversible loss of motor and sensory function. Neural stem/progenitor cells (NSCs/NPCs) possess neuroregenerative and neuroprotective features, and transplantation of such cells into the site of damaged tissue is a promising stem cell-based therapy for SCI. However, NSC/NPCs have mostly been induced from embryonic stem cells or fetal tissue, leading to ethical concerns. The pioneering work of Yamanaka and colleagues gave rise to the technology to induce pluripotent stem cells (iPSCs) from somatic cells, overcoming these ethical issues. The advent of iPSCs technology has meant significant progress in the therapy of neurodegenerative disease and nerve tissue damage. A number of published studies have described the successful differentiation of NSCs/NPCs from iPSCs and their subsequent engraftment into SCI animal models, followed by functional recovery of injury. The aim of this present review is to summarize various iPSC- NPCs differentiation methods, SCI modelling, and the current status of possible iPSC- NPCs- based therapy of SCI.", "subjects" : [ { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biological sciences", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10293, "link" : "/api/classification/10293", "label" : "Chemical sciences", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 366, "link" : "/api/keyword/366", "label" : "DIFFERENTIATION", "published" : true, "oldId" : 366, "snippet" : true }, { "otype" : "Keyword", "mtid" : 3119, "link" : "/api/keyword/3119", "label" : "regeneration", "published" : true, "oldId" : 3119, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1118411, "link" : "/api/keyword/1118411", "label" : "Spinal Cord Injuries", "published" : true, "oldId" : 1118411, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1131378, "link" : "/api/keyword/1131378", "label" : "Induced pluripotent stem cells", "published" : true, "oldId" : 1131378, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1339821, "link" : "/api/keyword/1339821", "label" : "Disease modeling", "published" : true, "oldId" : 1339821, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2022-10-11", "oaFree" : false, "oaLink" : "http://www.mdpi.com/journal/ijms", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10770369, "link" : "/api/sjrrating/10770369", "label" : "sjr:Q1 (2019) Scopus - Computer Science Applications INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067", "listPos" : 87, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1706, "link" : "/api/classificationexternal/1706", "label" : "Scopus - Computer Science Applications", "published" : true, "oldId" : 1706, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 8, "ownerInstituteCount" : 76, "directInstituteCount" : 0, "authorCount" : 4, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30997153", "label" : "Csobonyeiova Maria et al. Recent Progress in the Regeneration of Spinal Cord Injuries by Induced Pluripotent Stem Cells. (2019) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 20 15", "template" : "