Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background
and environmental triggers. Patients with psoriasis and psoriatic arthritis are at
greater risk of developing other chronic and potentially severe comorbidities, such
as psoriatic arthritis, hyperlipidemia, type 2 diabetes mellitus, obesity, metabolic
syndrome, cardiovascular diseases or depression. Recently, accumulating epidemiologic,
genetic and pathogenetic evidence indicates that psoriasis is also associated with
periodontitis, a chronic progressive inflammatory disease, which may result in tooth
loss without early and adequate therapy.Areas covered: In this review article we summarize
and discuss in detail the available epidemiologic, genetic, microbiological and immunological
links between psoriasis and periodontitis.Expertopinion: Periodontitis, via the immunomodulatory
effect of the oral microbiota, may play both a direct and indirect role in the development
or exacerbation of psoriasis, and may influence the efficacy of antipsoriatic therapy.
These new findings indicate a need for increased awareness, early recognition and
focus on prevention of periodontitis for patients with psoriasis.