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Du Pasquier-Fediaevsky, Laurence
Low-Dose Rituximab for Active Moderate to Severe Graves' Orbitopathy Resistant to Conventional Treatment
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Purpose: To report low-dose rituximab effect in Graves' orbitopathy (GO) resistant to conventional treatment. Methods: Retrospective analysis of medical records, filled in according to the European Group on Graves' Orbitopathy (EUGOGO) standards, of patients with active moderate-to-severe GO who received low-dose rituximab after failure of conventional treatment. Efficacy was defined by a decrease of the clinical activity score of 2 points or Results: Among 219 patients treated between 2012 and 2016 by pulse methylprednisolone, possibly followed by oral steroids and/or orbital radiotherapy, 15 (6.8%) finally received 100 mg rituximab doses (cumulative dose, 100-400 mg) owing to persistent active disease. Rituximab showed efficacy within 2 months in 13 of 15 (87%), stable at 1 year. No significant effect was observed on proptosis, lid fissure width, and eye motility. Conclusion: Low-dose rituximab showed sustained anti-inflammatory effect in most patients with active GO resistant to conventional treatment.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Du Pasquier-Fediaevsky, Laurence ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Andrei, Stefan </span> <span class="author-type"> </span> ; <span class="author-name" > Berche, Michel </span> <span class="author-type"> </span> ; <span class="author-name" > Leenhardt, Laurence </span> <span class="author-type"> </span> ; <span class="author-name" > Heron, Emmanuel </span> <span class="author-type"> </span> ; <span class="author-name" > Riviere, Sebastien </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30985758" mtid="30985758" target="_blank">Low-Dose Rituximab for Active Moderate to Severe Graves' Orbitopathy Resistant to Conventional Treatment</a></div> <div class="pub-info"> <span class="journal-title">OCULAR IMMUNOLOGY AND INFLAMMATION</span> <span class="journal-volume">27</span> : <span class="journal-issue">5</span> <span class="page"> pp. 844-850. , 7 p. </span> <span class="year">(2019)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1080/09273948.2018.1453078" target="_blank" href="https://doi.org/10.1080%2F09273948.2018.1453078"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="000480636000025" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000480636000025&DestApp=WOS"> WoS </a> </span> </span> </div> <span class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30985758 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző</span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </span> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Du Pasquier-Fediaevsky Laurence ✉ </span> ; <span class="author-name" >Andrei Stefan </span> ; <span class="author-name" >Berche Michel </span> ; <span class="author-name" >Leenhardt Laurence </span> ; <span class="author-name" >Heron Emmanuel </span> ; <span class="author-name" >Riviere Sebastien </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;30985758" target="_blank">Low-Dose Rituximab for Active Moderate to Severe Graves' Orbitopathy Resistant to Conventional Treatment</a></div> <div> <span class="journal-title">OCULAR IMMUNOLOGY AND INFLAMMATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0927-3948">0927-3948</a> )</span>: <span class="journal-volume">27</span> <span class="journal-issue">5</span> <span class="page"> pp 844-850 </span> <span class="year">(2019)</span> <br> </span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1080/09273948.2018.1453078" target="_blank" href="https://doi.org/10.1080%2F09273948.2018.1453078"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="000480636000025" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000480636000025&DestApp=WOS"> WoS </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30985758&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30985758</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | Tudományos </span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2019.12.11. 21:34 WoS import (admin) </div> </div></div>