Fizikai kémia, polimertudomány, elektrokémia (szárazelemek, akkumulátorok, üzemanyagcellák,
fémek korróziója, elektrolízis)
Kémiai tudományok
Természettudományok
Abstract Histone deacetylase (HDAC) inhibitors are considered as novel therapeutic
agents inducing cell cycle arrest and apoptotic cell death in various cancer cells.
Inhibition of deacetylase activity results in a relaxed chromatin structure thereby
rendering the genetic material more vulnerable to DNA targeting agents that could
be exploited by combinational cancer therapy. The unique potential of silver nanoparticles
(AgNPs) in tumor therapy relies on the generation of reactive radicals which trigger
oxidative stress, DNA damage and apoptosis in cancer cells. The revolutionary application
of AgNPs as chemotherapeutical drugs seems very promising, nevertheless the exact
molecular mechanisms of AgNP action in combination with other anti-cancer agents have
yet to be elucidated in details before clinical administrations. As a step towards
this we investigated the combinational effect of HDAC inhibition and AgNP administration
in HeLa cervical cancer cells. We identified synergistic inhibition of cancer cell
growth and migration upon combinational treatments. Here we report that the HDAC inhibitor
Trichostatin A enhances the DNA targeting capacity and apoptosis inducing efficacy
of AgNPs most probably due to its effect on chromatin condensation. These results
point to the potential benefits of combinational application of HDAC inhibitors and
AgNPs in novel cancer medication protocols.
