{ "labelLang" : "hun", "responseDate" : "2024-03-29 10:03", "content" : { "otype" : "JournalArticle", "mtid" : 30967195, "status" : "VALIDATED", "published" : true, "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2020-05-01T11:51:03.284+0000", "lastModified" : "2019-12-06T08:46:41.185+0000", "created" : "2019-12-06T08:46:40.845+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "lastDuplumOK" : "2019-12-06T08:46:40.252+0000", "lastDuplumSearch" : "2019-12-06T08:46:40.252+0000", "validated" : "2019-12-06T08:46:40.996+0000", "validator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Suwan, Keittisak", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 89122269, "link" : "/api/authorship/89122269", "label" : "Suwan, Keittisak", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : false, "familyName" : "Suwan", "givenName" : "Keittisak", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122270, "link" : "/api/authorship/89122270", "label" : "Yata, Teerapong", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Yata", "givenName" : "Teerapong", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122271, "link" : "/api/authorship/89122271", "label" : "Waramit, Sajee", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Waramit", "givenName" : "Sajee", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122272, "link" : "/api/authorship/89122272", "label" : "Przystal, Justyna M.", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Przystal", "givenName" : "Justyna M.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122273, "link" : "/api/authorship/89122273", "label" : "Stoneham, Charlotte A.", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Stoneham", "givenName" : "Charlotte A.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122274, "link" : "/api/authorship/89122274", "label" : "Bentayebi, Kaoutar", "listPosition" : 6, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Bentayebi", "givenName" : "Kaoutar", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122275, "link" : "/api/authorship/89122275", "label" : "Asavarut, Paladd", "listPosition" : 7, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Asavarut", "givenName" : "Paladd", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122276, "link" : "/api/authorship/89122276", "label" : "Chongchai, Aitthiphon", "listPosition" : 8, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Chongchai", "givenName" : "Aitthiphon", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122277, "link" : "/api/authorship/89122277", "label" : "Pothachareon, Peraphan", "listPosition" : 9, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Pothachareon", "givenName" : "Peraphan", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122278, "link" : "/api/authorship/89122278", "label" : "Lee, Koon-Yang", "listPosition" : 10, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Lee", "givenName" : "Koon-Yang", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122279, "link" : "/api/authorship/89122279", "label" : "Topanurak, Supachai", "listPosition" : 11, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Topanurak", "givenName" : "Supachai", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122280, "link" : "/api/authorship/89122280", "label" : "Smith, Tracey L.", "listPosition" : 12, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Smith", "givenName" : "Tracey L.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122281, "link" : "/api/authorship/89122281", "label" : "Gelovani, Juri G.", "listPosition" : 13, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Gelovani", "givenName" : "Juri G.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122282, "link" : "/api/authorship/89122282", "label" : "Sidman, Richard L. ✉", "listPosition" : 14, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Sidman", "givenName" : "Richard L.", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122283, "link" : "/api/authorship/89122283", "label" : "Pasqualini, Renata ✉", "listPosition" : 15, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Pasqualini", "givenName" : "Renata", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122284, "link" : "/api/authorship/89122284", "label" : "Arap, Wadih ✉", "listPosition" : 16, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Arap", "givenName" : "Wadih", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 89122285, "link" : "/api/authorship/89122285", "label" : "Hajitou, Amin ✉", "listPosition" : 17, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Hajitou", "givenName" : "Amin", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 16205853, "link" : "/api/publicationidentifier/16205853", "label" : "DOI: 10.1073/pnas.1906653116", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "idValue" : "10.1073/pnas.1906653116", "realUrl" : "https://doi.org/10.1073%2Fpnas.1906653116", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16205852, "link" : "/api/publicationidentifier/16205852", "label" : "WoS: 000485145400063", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "idValue" : "000485145400063", "realUrl" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000485145400063&DestApp=WOS", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 3547, "link" : "/api/journal/3547", "label" : "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490", "pIssn" : "0027-8424", "eIssn" : "1091-6490", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 3547, "snippet" : true }, "volume" : "116", "issue" : "37", "firstPage" : "18571", "lastPage" : "18577", "firstPageOrInternalIdForSort" : "18571", "pageLength" : 7, "publishedYear" : 2019, "abstractText" : "Bacteriophage (phage) have attractive advantages as delivery systems compared with mammalian viruses, but have been considered poor vectors because they lack evolved strategies to confront and overcome mammalian cell barriers to infective agents. We reasoned that improved efficacy of delivery might be achieved through structural modification of the viral capsid to avoid pre- and postinternalization barriers to mammalian cell transduction. We generated multifunctional hybrid adeno-associated virus/phage (AAVP) particles to enable simultaneous display of targeting ligands on the phage's minor pIII proteins and also degradation-resistance motifs on the very numerous pVIII coat proteins. This genetic strategy of directed evolution bestows a next-generation of AAVP particles that feature resistance to fibrinogen adsorption or neutralizing antibodies and ability to escape endolysosomal degradation. This results in superior gene transfer efficacy in vitro and also in preclinical mouse models of rodent and human solid tumors. Thus, the unique functions of our next-generation AAVP particles enable improved targeted gene delivery to tumor cells.", "subjects" : [ { "otype" : "Classification", "mtid" : 10799, "link" : "/api/classification/10799", "label" : "Egyéb természettudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 643, "link" : "/api/keyword/643", "label" : "CANCER", "published" : true, "oldId" : 643, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1008053, "link" : "/api/keyword/1008053", "label" : "GENE DELIVERY", "published" : true, "oldId" : 1008053, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1048610, "link" : "/api/keyword/1048610", "label" : "phage display", "published" : true, "oldId" : 1048610, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1517031, "link" : "/api/keyword/1517031", "label" : "Preclinical studies", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1842936, "link" : "/api/keyword/1842936", "label" : "AAVP", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2020-05-01", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "MtaRating", "mtid" : 519088, "link" : "/api/mtarating/519088", "label" : "SZTB:A PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490", "ratingType" : { "otype" : "RatingType", "mtid" : 10007, "link" : "/api/ratingtype/10007", "label" : "SZTB", "code" : "SZTB", "institute" : { "otype" : "Institute", "mtid" : 14102, "link" : "/api/institute/14102", "label" : "Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]", "childrenCount" : 0, "allowInstForum" : false, "allowOnlineRegistration" : true, "name" : "Szociológiai Tudományos Bizottság", "nameEng" : "Szociológiai Tudományos Bizottság", "published" : true, "oldId" : 14102, "snippet" : true }, "published" : true, "snippet" : true }, "val" : "A", "published" : true, "oldId" : 19088, "snippet" : true }, { "otype" : "MtaRating", "mtid" : 507784, "link" : "/api/mtarating/507784", "label" : "GMB:C PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490", "ratingType" : { "otype" : "RatingType", "mtid" : 10012, "link" : "/api/ratingtype/10012", "label" : "GMB", "code" : "GMB", "institute" : { "otype" : "Institute", "mtid" : 19066, "link" : "/api/institute/19066", "label" : "Gazdaságtudományi Doktori Minősítő Bizottság IXGJO GMB [1901-]", "childrenCount" : 0, "allowInstForum" : false, "allowOnlineRegistration" : true, "name" : "Gazdaságtudományi Doktori Minősítő Bizottság", "nameEng" : "Gazdaságtudományi Doktori Minősítő Bizottság", "published" : true, "oldId" : 19066, "snippet" : true }, "published" : true, "snippet" : true }, "val" : "C", "published" : true, "oldId" : 7784, "snippet" : true }, { "otype" : "SjrRating", "mtid" : 10859064, "link" : "/api/sjrrating/10859064", "label" : "sjr:D1 (2019) Scopus - Multidisciplinary PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490", "listPos" : 4, "rankValue" : 0.0, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1000, "link" : "/api/classificationexternal/1000", "label" : "Scopus - Multidisciplinary", "published" : true, "oldId" : 1000, "snippet" : true }, "ranking" : "D1", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "mtaRatingsForSort" : "A", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 1, "ownerInstituteCount" : 3, "directInstituteCount" : 0, "authorCount" : 17, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30967195", "label" : "Suwan Keittisak et al. Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer. (2019) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490 116 37 18571-18577", "template" : "