{ "labelLang" : "hun", "responseDate" : "2024-03-29 12:54", "content" : { "otype" : "JournalArticle", "mtid" : 30949644, "status" : "ADMIN_APPROVED", "published" : true, "comment" : "Cell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :3 \n Export Date: 30 March 2020 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu \n Funding details: W81XWH-15-1-0284, W81XWH-13-1-0284 \n Funding details: National Sleep Foundation, NSF, 1456862 \n Funding text 1: We would like to thank the following: Nameer B. Kirma and Nicholas D. Lucio from the Bioanalytics and Single-Cell Facility at UT Health San Antonio for the multiplex immunoassays. We also thank Brian J. Lund at the San Antonio Military Medical Center for advice on use of the blast facility, and Amy E. Pletz for her expert technical assistance. This study was supported by DoD CDMRP grants W81XWH-15-1-0284 (M.S.S. and R.B.) and W81XWH-13-1-0284 ( J.D.L.), NSF grant 1456862 (R.B.) and the Morrison Trust Foundation grants (R.B. and M.S.S.)\nCell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :4 \n Export Date: 30 July 2020 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu \n Funding details: W81XWH-15-1-0284, W81XWH-13-1-0284 \n Funding details: National Sleep Foundation, NSF, 1456862 \n Funding text 1: We would like to thank the following: Nameer B. Kirma and Nicholas D. Lucio from the Bioanalytics and Single-Cell Facility at UT Health San Antonio for the multiplex immunoassays. We also thank Brian J. Lund at the San Antonio Military Medical Center for advice on use of the blast facility, and Amy E. Pletz for her expert technical assistance. This study was supported by DoD CDMRP grants W81XWH-15-1-0284 (M.S.S. and R.B.) and W81XWH-13-1-0284 ( J.D.L.), NSF grant 1456862 (R.B.) and the Morrison Trust Foundation grants (R.B. and M.S.S.)\nCell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :4 \n Export Date: 31 July 2020 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu \n Funding details: W81XWH-15-1-0284, W81XWH-13-1-0284 \n Funding details: National Sleep Foundation, NSF, 1456862 \n Funding text 1: We would like to thank the following: Nameer B. Kirma and Nicholas D. Lucio from the Bioanalytics and Single-Cell Facility at UT Health San Antonio for the multiplex immunoassays. We also thank Brian J. Lund at the San Antonio Military Medical Center for advice on use of the blast facility, and Amy E. Pletz for her expert technical assistance. This study was supported by DoD CDMRP grants W81XWH-15-1-0284 (M.S.S. and R.B.) and W81XWH-13-1-0284 ( J.D.L.), NSF grant 1456862 (R.B.) and the Morrison Trust Foundation grants (R.B. and M.S.S.)\nCell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :8 \n Export Date: 16 April 2021 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu \n Funding details: W81XWH-13-1-0284, W81XWH-15-1-0284 \n Funding details: National Sleep Foundation, NSF, 1456862 \n Funding text 1: We would like to thank the following: Nameer B. Kirma and Nicholas D. Lucio from the Bioanalytics and Single-Cell Facility at UT Health San Antonio for the multiplex immunoassays. We also thank Brian J. Lund at the San Antonio Military Medical Center for advice on use of the blast facility, and Amy E. Pletz for her expert technical assistance. This study was supported by DoD CDMRP grants W81XWH-15-1-0284 (M.S.S. and R.B.) and W81XWH-13-1-0284 ( J.D.L.), NSF grant 1456862 (R.B.) and the Morrison Trust Foundation grants (R.B. and M.S.S.)\nCell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :9 \n Export Date: 3 June 2021 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu\nCell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :12 \n Export Date: 20 September 2021 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu \n Funding details: W81XWH-13-1-0284, W81XWH-15-1-0284 \n Funding details: National Sleep Foundation, NSF, 1456862 \n Funding text 1: We would like to thank the following: Nameer B. Kirma and Nicholas D. Lucio from the Bioanalytics and Single-Cell Facility at UT Health San Antonio for the multiplex immunoassays. We also thank Brian J. Lund at the San Antonio Military Medical Center for advice on use of the blast facility, and Amy E. Pletz for her expert technical assistance. This study was supported by DoD CDMRP grants W81XWH-15-1-0284 (M.S.S. and R.B.) and W81XWH-13-1-0284 ( J.D.L.), NSF grant 1456862 (R.B.) and the Morrison Trust Foundation grants (R.B. and M.S.S.)\nCell and Integrative Physiology, University of Texas Health San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, United States \n Department of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, TX, United States \n Department of Neurology, University of Texas Health San Antonio, San Antonio, TX, United States \n Sensory Trauma, United States Army, Institute of Surgical Research, Fort Sam Houston, San Antonio, TX, United States \n Applied Research Assoc., San Antonio, TX, United States \n Cited By :12 \n Export Date: 21 September 2021 \n CODEN: JNEUE \n Correspondence Address: Brenner, R.; Cell and Integrative Physiology, 8403 Floyd Curl Drive, United States; email: brennerr@uthscsa.edu \n Funding details: W81XWH-13-1-0284, W81XWH-15-1-0284 \n Funding details: National Sleep Foundation, NSF, 1456862 \n Funding text 1: We would like to thank the following: Nameer B. Kirma and Nicholas D. Lucio from the Bioanalytics and Single-Cell Facility at UT Health San Antonio for the multiplex immunoassays. We also thank Brian J. Lund at the San Antonio Military Medical Center for advice on use of the blast facility, and Amy E. Pletz for her expert technical assistance. 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"snippet" : true }, "volume" : "37", "issue" : "2", "firstPage" : "248", "lastPage" : "261", "firstPageOrInternalIdForSort" : "248", "pageLength" : 14, "publishedYear" : 2020, "abstractText" : "Repetitive blast traumatic brain injury (TBI) affects numerous soldiers on the battlefield. Mild TBI has been shown to have long-lasting effects with repeated injury. We have investigated effects on neuronal excitability after repetitive, mild TBI in a mouse model of blast-induced brain injury. We exposed mice to mild blast trauma of an average peak overpressure of 14.6 psi, repeated across three consecutive days. While a single exposure did not reveal trauma as indicated by the glial fibrillary acidic protein indicator, three repetitive blasts did show significant increases. As well, mice had an increased indicator of inflammation (Iba-1) and increased tau, tau phosphorylation, and altered cytokine levels in the spleen. Video-electroencephalographic monitoring 48 h after the final blast exposure demonstrated seizures in 50% (12/24) of the mice, most of which were non-convulsive seizures. Long-term monitoring revealed that spontaneous seizures developed in at least 46% (6/13) of the mice. Patch clamp recording of dentate gyrus hippocampus neurons 48 h post-blast TBI demonstrated a shortened latency to the first spike and hyperpolarization of action potential threshold. We also found that evoked excitatory postsynaptic current amplitudes were significantly increased. These findings indicate that mild, repetitive blast exposures cause increases in neuronal excitability and seizures and eventual epilepsy development in some animals. The non-convulsive nature of the seizures suggests that subclinical seizures may occur in individuals experiencing even mild blast events, if repeated.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 1548, "link" : "/api/keyword/1548", "label" : "EPILEPSY", "published" : true, "oldId" : 1548, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2881, "link" : "/api/keyword/2881", "label" : "BLAST", "published" : true, "oldId" : 2881, "snippet" : true }, { "otype" : "Keyword", "mtid" : 15329, "link" : "/api/keyword/15329", "label" : "traumatic brain injury", "published" : true, "oldId" : 15329, "snippet" : true }, { "otype" : "Keyword", "mtid" : 15335, "link" : "/api/keyword/15335", "label" : "Mild traumatic brain injury", "published" : true, "oldId" : 15335, "snippet" : true }, { "otype" : "Keyword", "mtid" : 17869, "link" : "/api/keyword/17869", "label" : "seizure", "published" : true, "oldId" : 17869, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1528520, "link" : "/api/keyword/1528520", "label" : "repetitive mTBI", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : false, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-01-31", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 5, "citedCount" : 5, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10861492, "link" : "/api/sjrrating/10861492", "label" : "sjr:Q1 (2020) Scopus - Neurology (clinical) JOURNAL OF NEUROTRAUMA 0897-7151", "listPos" : 56, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2728, "link" : "/api/classificationexternal/2728", "label" : "Scopus - Neurology (clinical)", "published" : true, "oldId" : 2728, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2021-11-27T10:48:56.872+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 14, "ownerInstituteCount" : 57, "directInstituteCount" : 0, "authorCount" : 13, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30949644", "label" : "Bugay Vladislav et al. 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