https://m2.mtmt.hu/ hun 2026-05-01 20:53 JournalArticle 30939202 APPROVED true TTK-NAP B - Drug Discovery Research Group – Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, United Kingdom Cantabio Pharmaceuticals, Palo Alto, CA, United States Institute of Materials and Environmental Chemistry Research Centre for Natural Sciences, Budapest, Hungary Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom MS Metabolomic Research Laboratory, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary Department of Medicinal Chemistry and Molecular Pharmacology and Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, United States Export Date: 29 November 2019 CODEN: NUDIE Correspondence Address: Tóth, G.; TTK-NAP B - Drug Discovery Research Group – Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural SciencesHungary; email: toth.gergely@ttk.hu Chemicals/CAS: alpha synuclein, 154040-18-3; amyloid, 11061-24-8; cysteine, 4371-52-2, 52-89-1, 52-90-4; glyoxalase, 37347-76-5; serine, 56-45-1, 6898-95-9 0 false 2026-04-27T08:24:26.167+0000 2021-02-18T11:06:34.110+0000 2019-11-29T13:23:14.798+0000 true 10000609 Zsila Ferenc /api/author/10000609 Author Zsila Ferenc (Cirkuláris dikroizmus és elektronabszorpciós spektroszkópia) true 10000609 2026-04-27T08:22:18.029+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Solti, K. true true /api/journal/14239 REVIEWED NEUROBIOLOGY OF DISEASE 0969-9961 1095-953X true false 14239 false 14239 true 0969-9961 1095-953X Journal FOREIGN 134 104629 104629 2020 The loss of native function of the DJ-1 protein has been linked to the development of Parkinson's (PD) and other neurodegenerative diseases. Here we show that DJ-1 aggregates into β-sheet structured soluble and fibrillar aggregates in vitro under physiological conditions and that this process is promoted by the oxidation of its catalytic Cys106 residue. This aggregation resulted in the loss of its native biochemical glyoxalase function and in addition oxidized DJ-1 aggregates were observed to localize within Lewy bodies, neurofibrillary tangles and amyloid plaques in human PD and Alzheimer's (AD) patients' post-mortem brain tissue. These findings suggest that the aggregation of DJ-1 may be a critical player in the development of the pathology of PD and AD and demonstrate that loss of DJ-1 function can happen through DJ-1 aggregation. This could then contribute to AD and PD disease onset and progression. © 2019 Elsevier Inc. 2019 true true true false true false NONE 2026-04-27 false 13 0 13 10 1 13 13 12 13 13 13 10 10 10 3 0 13 10 13 10 0 2 2 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 3 1 3 1 2021 0 4 3 4 3 2022 0 1 1 1 1 2023 0 3 3 3 3 2024 0 1 1 1 1 2025 0 1 1 1 1 D1 false 10014805,10039427 false false false 2020-03-01T09:24:07.925+0000 Anyag- és Környezetkémiai Intézet (TTK); Biológiai Nanokémiai Kutatócsoport (HRN TTK / AKI); MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurode... (HRN TTK / SZKI); Műszercentrum (TTK) 8 47 4 18 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 88879547 /api/authorship/88879547 Solti, K. ✉ 1 0.055555556 true false true Solti K. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879548 /api/authorship/88879548 Kuan, W.-L. 2 0.055555556 false false false Kuan W.-L. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879549 /api/authorship/88879549 Fórizs, B. 3 0.055555556 false false false Fórizs B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879550 /api/authorship/88879550 Kustos, G. 4 0.055555556 false false false Kustos G. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879551 /api/authorship/88879551 Mihály, J. [Mihály, Judith (IR és Raman spekt...), szerző] Anyag- és Környezetkémiai Intézet (TTK); Biológiai Nanokémiai Kutatócsoport (HRN TTK / AKI) 5 0.055555556 false false false Author 10010387 /api/author/10010387 Mihály Judith (IR és Raman spektroszkópia, biofizika) Mihály Judith true 10010387 true Mihály J. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879552 /api/authorship/88879552 Varga, Z. [Varga, Zoltán (biofizika, kolloi...), szerző] Anyag- és Környezetkémiai Intézet (TTK); Biológiai Nanokémiai Kutatócsoport (HRN TTK / AKI) 6 0.055555556 false false false Author 10014807 /api/author/10014807 Varga Zoltán (biofizika, kolloidkémia) Varga Zoltán true 10014807 true Varga Z. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879553 /api/authorship/88879553 Herberth, B. [Herberth, Balázs (Idegi fejlődésbio...), szerző] MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurode... (HRN TTK / SZKI) 7 0.055555556 false false false Author 10012358 /api/author/10012358 Herberth Balázs (Idegi fejlődésbiológia, biológus) Herberth Balázs true 10012358 true Herberth B. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879554 /api/authorship/88879554 Moravcsik, É. 8 0.055555556 false false false Moravcsik É. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879555 /api/authorship/88879555 Kiss, R. ✉ [Kiss, Róbert (gyógyszerkutatás), szerző] MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurode... (HRN TTK / SZKI) 9 0.055555556 false false true Author 10058698 /api/author/10058698 Kiss Róbert (gyógyszerkutatás) Kiss Róbert true 10058698 true Kiss R. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879556 /api/authorship/88879556 Kárpáti, M. [Kárpáti, Manuéla (molekuláris sejtb...), szerző] 10 0.055555556 false false false Author 10040074 /api/author/10040074 Kárpáti Manuéla (molekuláris sejtbiológia) Kárpáti Manuéla true 10040074 true Kárpáti M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879557 /api/authorship/88879557 Mikes, A. [Mikes, Anna (biológus), szerző] MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurode... (HRN TTK / SZKI) 11 0.055555556 false false false Author 10070998 /api/author/10070998 Mikes Anna (biológus) Mikes Anna true true Mikes A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879558 /api/authorship/88879558 Zhao, Y. 12 0.055555556 false false false Zhao Y. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879559 /api/authorship/88879559 Imre, T. [Imre, Timea (Tömegspektrometria), szerző] Műszercentrum (TTK) 13 0.055555556 false false false Author 10014805 /api/author/10014805 Imre Timea (Tömegspektrometria) Imre Timea true 10014805 true Imre T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879560 /api/authorship/88879560 Rochet, J.-C. 14 0.055555556 false false false Rochet J.-C. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879561 /api/authorship/88879561 Aigbirhio, F. 15 0.055555556 false false false Aigbirhio F. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879562 /api/authorship/88879562 Williams-Gray, C.H. 16 0.055555556 false false false Williams-Gray C.H. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879563 /api/authorship/88879563 Barker, R.A. 17 0.055555556 false false false Barker R.A. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88879564 /api/authorship/88879564 Tóth, G. ✉ [Tóth, Gergely (neuroscience), szerző] MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurode... (HRN TTK / SZKI) 18 0.055555556 false true true Author 10039427 /api/author/10039427 Tóth Gergely (neuroscience) Tóth Gergely true 10039427 true Tóth G. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 16150168 /api/publicationidentifier/16150168 DOI: 10.1016/j.nbd.2019.104629 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.nbd.2019.104629 https://doi.org/10.1016/j.nbd.2019.104629 false true PublicationIdentifier 18451596 /api/publicationidentifier/18451596 WoS: 000509818400020 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000509818400020 https://www.webofscience.com/wos/woscc/full-record/000509818400020 true 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/api/keyword/3176 CATALYSIS true 3176 true Keyword 4394 /api/keyword/4394 Molecular weight true 4394 true Keyword 4524 /api/keyword/4524 protein localization true 4524 true Keyword 4600 /api/keyword/4600 priority journal true 4600 true Keyword 4608 /api/keyword/4608 controlled study true 4608 true Keyword 5412 /api/keyword/5412 Histopathology true 5412 true Keyword 6586 /api/keyword/6586 in vitro study true 6586 true Keyword 6662 /api/keyword/6662 protein phosphorylation true 6662 true Keyword 6666 /api/keyword/6666 enzyme activity true 6666 true Keyword 6668 /api/keyword/6668 cellular distribution true 6668 true Keyword 8129 /api/keyword/8129 Protein Stability true 8129 true Keyword 8513 /api/keyword/8513 Autopsy true 8513 true Keyword 10949 /api/keyword/10949 Solubility true 10949 true Keyword 12980 /api/keyword/12980 CYSTEINE true 12980 true Keyword 13171 /api/keyword/13171 PROTEIN FUNCTION true 13171 true Keyword 13979 /api/keyword/13979 human cell true 13979 true Keyword 14231 /api/keyword/14231 onset age true 14231 true Keyword 14302 /api/keyword/14302 disease exacerbation true 14302 true Keyword 14679 /api/keyword/14679 human tissue true 14679 true Keyword 17751 /api/keyword/17751 Parkinson disease true 17751 true Keyword 19969 /api/keyword/19969 serine true 19969 true Keyword 1002329 /api/keyword/1002329 amyloid true 1002329 true Keyword 1002329 /api/keyword/1002329 amyloid true 1002329 true Keyword 1006706 /api/keyword/1006706 upregulation true 1006706 true Keyword 1006832 /api/keyword/1006832 oxidation reduction reaction true 1006832 true Keyword 1009611 /api/keyword/1009611 Alzheimer disease true 1009611 true Keyword 1010979 /api/keyword/1010979 amyloid beta protein[1-42] true 1010979 true Keyword 1013426 /api/keyword/1013426 alpha helix true 1013426 true Keyword 1020369 /api/keyword/1020369 frontal cortex true 1020369 true Keyword 1047363 /api/keyword/1047363 protein aggregation true 1047363 true Keyword 1047364 /api/keyword/1047364 neurofibrillary tangle true 1047364 true Keyword 1047367 /api/keyword/1047367 Lewy body true 1047367 true Keyword 1047377 /api/keyword/1047377 alpha synuclein true 1047377 true Keyword 1052313 /api/keyword/1052313 Protein misfolding true 1052313 true Keyword 1066366 /api/keyword/1066366 tau protein true 1066366 true Keyword 1067983 /api/keyword/1067983 homodimer true 1067983 true Keyword 1079891 /api/keyword/1079891 beta sheet true 1079891 true Keyword 1124163 /api/keyword/1124163 protein homeostasis true 1124163 true Keyword 1412268 /api/keyword/1412268 Parkinson’s true 1412268 true Keyword 1412275 /api/keyword/1412275 Alzheimer’s true 1412275 true Keyword 1494623 /api/keyword/1494623 glyoxalase true true Keyword 1495684 /api/keyword/1495684 amyloid plaque true true Keyword 1512638 /api/keyword/1512638 protein deglycase DJ-1 true true Keyword 1528065 /api/keyword/1528065 DJ-1 true true Keyword 2373926 /api/keyword/2373926 amygdala true true SjrRating 10860871 /api/sjrrating/10860871 sjr:D1 (2020) Scopus - Neurology NEUROBIOLOGY OF DISEASE 0969-9961 1095-953X 14 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2808 /api/classificationexternal/2808 Scopus - Neurology true 2808 true D1 DIRECT true true Reference 2557501 /api/reference/2557501 1. Aleyasin, H., Rousseaux, M.W., Phillips, M., Kim, R.H., Bland, R.J., Callaghan, S., Slack, R.S., Park, D.S., The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 18748-18753 1 false true Reference 2557502 /api/reference/2557502 2. Ariga, H., Takahashi-Niki, K., Kato, I., Maita, H., Niki, T., Iguchi-Ariga, S.M., Neuroprotective function of DJ-1 in Parkinson's disease (2013) Oxidative Med. Cell. Longev., 2013 2 false true Reference 2557503 /api/reference/2557503 3. Aslund, A., Sigurdson, C.J., Klingstedt, T., Grathwohl, S., Bolmont, T., Dickstein, D.L., Glimsdal, E., Konradsson, P., Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses (2009) ACS Chem. Biol., 4, pp. 673-684 3 false true Reference 2557504 /api/reference/2557504 4. Baulac, S., LaVoie, M.J., Strahle, J., Schlossmacher, M.G., Xia, W., Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain (2004) Mol. Cell. Neurosci., 27, pp. 236-246 4 false true Reference 2557505 /api/reference/2557505 5. Bonifati, V., Rizzu, P., van Baren, M.J., Schaap, O., Breedveld, G.J., Krieger, E., Dekker, M.C., Joosse, M., Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism (2003) Science, 299, pp. 256-259 5 false true Reference 2557506 /api/reference/2557506 6. Cao, J., Lou, S., Ying, M., Yang, B., DJ-1 as a human oncogene and potential therapeutic target (2015) Biochem. Pharmacol., 93, pp. 241-250 6 false true Reference 2557507 /api/reference/2557507 7. Cha, S.S., Jung, H.I., Jeon, H., An, Y.J., Kim, I.K., Yun, S., Ahn, H.J., Kang, S.O., Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner (2008) J. Biol. Chem., 283, pp. 34069-34075 7 false true Reference 2557508 /api/reference/2557508 8. Chan, F.T., Kaminski Schierle, G.S., Kumita, J.R., Bertoncini, C.W., Dobson, C.M., Kaminski, C.F., Protein amyloids develop an intrinsic fluorescence signature during aggregation (2013) Analyst, 138, pp. 2156-2162 8 false true Reference 2557509 /api/reference/2557509 9. Chen, J., Li, L., Chin, L.S., Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage (2010) Hum. Mol. Genet., 15 (12), pp. 2395-2408 9 false true Reference 2557510 /api/reference/2557510 10. Choi, J., Sullards, M.C., Olzmann, J.A., Rees, H.D., Weintraub, S.T., Bostwick, D.E., Gearing, M., Li, L., Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases (2006) J. Biol. Chem., 281, pp. 10816-10824 10 false true Reference 2557511 /api/reference/2557511 11. Conway, K.A., Harper, J.D., Lansbury, P.T., Jr., Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid (2000) Biochemistry, 39, pp. 2552-2563 11 false true Reference 2557512 /api/reference/2557512 12. Drummond, E., Nayak, S., Faustin, A., Pires, G., Hickman, R.A., Askenazi, M., Cohen, M., Han, X., Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease (2017) Acta Neuropathol., 133, pp. 933-954 12 false true Reference 2557513 /api/reference/2557513 13. Glenner, G.G., Wong, C.W., Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein (1984) Biochem. Biophys. Res. Commun., 120, pp. 885-890 13 false true Reference 2557514 /api/reference/2557514 14. Hanagasi, H.A., Giri, A., Kartal, E., Guven, G., Bilgic, B., Hauser, A.K., Emre, M., Gasser, T., A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family (2016) Parkinsonism Relat. Disord., 29, pp. 117-120 14 false true Reference 2557515 /api/reference/2557515 15. Herrera, F.E., Zucchelli, S., Jezierska, A., Lavina, Z.S., Gustincich, S., Carloni, P., On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson disease. A combined computational and in vitro study (2007) J. Biol. Chem., 282, pp. 24905-24914 15 false true Reference 2557516 /api/reference/2557516 16. Honbou, K., Suzuki, N.N., Horiuchi, M., Niki, T., Taira, T., Ariga, H., Inagaki, F., The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease (2003) J. Biol. Chem., 278, pp. 31380-31384 16 false true Reference 2557517 /api/reference/2557517 17. Inberg, A., Linial, M., Protection of pancreatic beta-cells from various stress conditions is mediated by DJ-1 (2010) J. Biol. Chem., 285, pp. 25686-25698 17 false true Reference 2557518 /api/reference/2557518 18. Jain, D., Jain, R., Eberhard, D., Eglinger, J., Bugliani, M., Piemonti, L., Marchetti, P., Lammert, E., Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes (2012) J. Mol. Cell Biol., 4, pp. 221-230 18 false true Reference 2557519 /api/reference/2557519 19. Kahle, P.J., Waak, J., Gasser, T., DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders (2009) Free Radic. Biol. Med., 47, pp. 1354-1361 19 false true Reference 2557520 /api/reference/2557520 20. Kim, M.S., Lee, S., Yun, S., Suh, P.G., Park, J., Cui, M., Choi, S., Jin, W., Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation (2018) Int. J. Biol. Macromol., 107, pp. 1650-1658 20 false true Reference 2557521 /api/reference/2557521 21. Kinumi, T., Kimata, J., Taira, T., Ariga, H., Niki, E., Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells (2004) Biochem. Biophys. Res. Commun., 317, pp. 722-728 21 false true Reference 2557522 /api/reference/2557522 22. Kiss, R., Zhu, M., Jojart, B., Czajlik, A., Solti, K., Forizs, B., Nagy, E., Toth, G., Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease (1861) Biochim. Biophys. Acta, 2017, pp. 2619-2629 22 false true Reference 2557523 /api/reference/2557523 23. Lee, V.M., Goedert, M., Trojanowski, J.Q., Neurodegenerative tauopathies (2001) Annu. Rev. Neurosci., 24, pp. 1121-1159 23 false true Reference 2557524 /api/reference/2557524 24. Lee, J.Y., Song, J., Kwon, K., Jang, S., Kim, C., Baek, K., Kim, J., Park, C., Human DJ-1 and its homologs are novel glyoxalases (2012) Hum. Mol. Genet., 21, pp. 3215-3225 24 false true Reference 2557525 /api/reference/2557525 25. Meulener, M.C., Graves, C.L., Sampathu, D.M., Armstrong-Gold, C.E., Bonini, N.M., Giasson, B.I., DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein (2005) J. Neurochem., 93, pp. 1524-1532 25 false true Reference 2557526 /api/reference/2557526 26. Meulener, M.C., Graves, C.L., Sampathu, D.M., Armstrong-Gold, C.E., Bonini, N.M., Giasson, B.I., DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein (2005) J. Neurochem., 93, pp. 1524-1532 26 false true Reference 2557527 /api/reference/2557527 27. Micsonai, A., Wien, F., Kernya, L., Lee, Y.H., Goto, Y., Refregiers, M., Kardos, J., Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy (2015) Proc. Natl. Acad. Sci. U. S. A., 112, pp. E3095-E3103 27 false true Reference 2557528 /api/reference/2557528 28. Moore, D.J., Zhang, L., Troncoso, J., Lee, M.K., Hattori, N., Mizuno, Y., Dawson, T.M., Dawson, V.L., Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress (2005) Hum. Mol. Genet., 14, pp. 71-84 28 false true Reference 2557529 /api/reference/2557529 29. Nural, H., He, P., Beach, T., Sue, L., Xia, W., Shen, Y., Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients (2009) Mol. Neurodegener., 4, p. 23 29 false true Reference 2557530 /api/reference/2557530 30. Ramsey, C.P., Giasson, B.I., L10p and P158DEL DJ-1 mutations cause protein instability, aggregation, and dimerization impairments (2010) J. Neurosci. Res., 88, pp. 3111-3124 30 false true Reference 2557531 /api/reference/2557531 31. Richarme, G., Liu, C., Mihoub, M., Abdallah, J., Leger, T., Joly, N., Liebart, J.C., Bouloc, P., Guanine glycation repair by DJ-1/Park7 and its bacterial homologs (2017) Science, 357, pp. 208-211 31 false true Reference 2557532 /api/reference/2557532 32. Riek, R., Eisenberg, D.S., The activities of amyloids from a structural perspective (2016) Nature, 539, pp. 227-235 32 false true Reference 2557533 /api/reference/2557533 33. Rizzu, P., Hinkle, D.A., Zhukareva, V., Bonifati, V., Severijnen, L.A., Martinez, D., Ravid, R., Lee, V.M., DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia (2004) Ann. Neurol., 55, pp. 113-118 33 false true Reference 2557534 /api/reference/2557534 34. Saito, Y., Oxidized DJ-1 as a possible biomarker of Parkinson's disease (2014) J. Clin. Biochem. Nutr., 54, pp. 138-144 34 false true Reference 2557535 /api/reference/2557535 35. Saito, Y., Miyasaka, T., Hatsuta, H., Takahashi-Niki, K., Hayashi, K., Mita, Y., Kusano-Arai, O., Hamakubo, T., Immunostaining of oxidized DJ-1 in human and mouse brains (2014) J. Neuropathol. Exp. Neurol., 73, pp. 714-728 35 false true Reference 2557536 /api/reference/2557536 36. Saito, Y., Akazawa-Ogawa, Y., Matsumura, A., Saigoh, K., Itoh, S., Sutou, K., Kobayashi, M., Hisahara, S., Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients (2016) Sci. Rep., 6 36 false true Reference 2557537 /api/reference/2557537 37. Selkoe, D.J., Hardy, J., The amyloid hypothesis of Alzheimer's disease at 25 years (2016) EMBO Mol. Med., 8, pp. 595-608 37 false true Reference 2557538 /api/reference/2557538 38. Shendelman, S., Jonason, A., Martinat, C., Leete, T., Abeliovich, A., DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation (2004) PLoS Biol., 2, p. e362 38 false true Reference 2557539 /api/reference/2557539 39. Sipe, J.D., Benson, M.D., Buxbaum, J.N., Ikeda, S.I., Merlini, G., Saraiva, M.J., Westermark, P., Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines (2016) Amyloid, 23, pp. 209-213 39 false true Reference 2557540 /api/reference/2557540 40. Smith, N., Wilson, M.A., Structural biology of the DJ-1 superfamily (2017) Adv. Exp. Med. Biol., 1037, pp. 5-24 40 false true Reference 2557541 /api/reference/2557541 41. Spillantini, M.G., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q., Jakes, R., Goedert, M., Alpha-synuclein in Lewy bodies (1997) Nature, 388, pp. 839-840 41 false true Reference 2557542 /api/reference/2557542 42. Taipa, R., Pereira, C., Reis, I., Alonso, I., Bastos-Lima, A., Melo-Pires, M., Magalhaes, M., DJ-1 linked parkinsonism (PARK7) is associated with Lewy body pathology (2016) Brain, 139, pp. 1680-1687 42 false true Reference 2557543 /api/reference/2557543 43. Wilson, M.A., The role of cysteine oxidation in DJ-1 function and dysfunction (2011) Antioxid. Redox Signal., 15, pp. 111-122 43 false true Reference 2557544 /api/reference/2557544 44. Yamagishi, Y., Saigoh, K., Saito, Y., Ogawa, I., Mitsui, Y., Hamada, Y., Samukawa, M., Hirano, M., Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein (2018) Neurosci. Res., 128, pp. 58-62 44 false true Reference 2557545 /api/reference/2557545 45. Zhou, W., Zhu, M., Wilson, M.A., Petsko, G.A., Fink, A.L., The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein (2006) J. Mol. Biol., 356, pp. 1036-104 45 false true /api/publication/30939202 Solti K. et al. DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits. (2020) NEUROBIOLOGY OF DISEASE 0969-9961 1095-953X 134<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Solti K. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kuan W.-L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fórizs B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kustos G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010387"><a href="/gui2/?type=authors&mode=browse&sel=10010387" target="_blank">Mihály J. (<span class="authorship-author-name">Mihály Judith</span> <span class="authorAux-mtmt"> IR és Raman spektroszkópia, biofizika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Anyag- és Környezetkémiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Anyag- és Környezetkémiai Intézet">AKI</span>/Biológiai Nanokémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014807"><a href="/gui2/?type=authors&mode=browse&sel=10014807" target="_blank">Varga Z. (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> biofizika, kolloidkémia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Anyag- és Környezetkémiai Intézet; <span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Anyag- és Környezetkémiai Intézet">AKI</span>/Biológiai Nanokémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012358"><a href="/gui2/?type=authors&mode=browse&sel=10012358" target="_blank">Herberth B. (<span class="authorship-author-name">Herberth Balázs</span> <span class="authorAux-mtmt"> Idegi fejlődésbiológia, biológus</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurodegeneratív betegségek</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Moravcsik É. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058698"><a href="/gui2/?type=authors&mode=browse&sel=10058698" target="_blank">Kiss R. ✉ (<span class="authorship-author-name">Kiss Róbert</span> <span class="authorAux-mtmt"> gyógyszerkutatás</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurodegeneratív betegségek</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040074"><a href="/gui2/?type=authors&mode=browse&sel=10040074" target="_blank">Kárpáti M. (<span class="authorship-author-name">Kárpáti Manuéla</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070998"><a href="/gui2/?type=authors&mode=browse&sel=10070998" target="_blank">Mikes A. (<span class="authorship-author-name">Mikes Anna</span> <span class="authorAux-mtmt"> biológus</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurodegeneratív betegségek</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhao Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014805"><a href="/gui2/?type=authors&mode=browse&sel=10014805" target="_blank">Imre T. (<span class="authorship-author-name">Imre Timea</span> <span class="authorAux-mtmt"> Tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Műszercentrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rochet J.-C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aigbirhio F. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Williams-Gray C.H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barker R.A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039427"><a href="/gui2/?type=authors&mode=browse&sel=10039427" target="_blank">Tóth G. ✉ (<span class="authorship-author-name">Tóth Gergely</span> <span class="authorAux-mtmt"> neuroscience</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/<span title="Szerves Kémiai Intézet">SZKI</span>/MTA-TTK-NAP B Gyógyszerkutató Csoport - Neurodegeneratív betegségek</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30939202" target="_blank">DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits</a></div> <div> <span class="journal-title">NEUROBIOLOGY OF DISEASE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0969-9961">0969-9961</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1095-953X">1095-953X</a>)</span>: <span class="journal-volume">134</span> <span class="page"> Paper 104629. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.nbd.2019.104629" target="_blank" href="https://doi.org/10.1016/j.nbd.2019.104629"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000509818400020" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000509818400020"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074968402" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074968402"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31669752" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31669752&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/85074968402?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/85074968402?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 13</span> | Független: 10 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt:&nbsp;13 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30939202&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30939202</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2021.02.18. 12:06 Farkas Andrea (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: TTK-NAP B - Drug Discovery Research Group – Neurodegenerative Diseases, Institute of Organic Chemistry, Research Center for Natural Sciences, Budapest, Hungary John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, United Kingdom Cantabio Pharmaceuticals...</pre> </div></div>