https://m2.mtmt.hu/ hun 2026-10-23 21:00 JournalArticle 30935721 VALIDATED true Funding Agency and Grant Number: St Jude Medical, Inc. Funding text: The AMICA trial (Atrial Fibrillation Management in Congestive Heart Failure With Ablation) was funded by St Jude Medical, Inc. 0 false 2026-10-22T15:32:36.724+0000 2022-11-24T18:59:08.738+0000 2019-11-27T11:29:15.777+0000 true 10055096 Nagy Regina /api/admin/10055096 Admin true 10055096 2024-10-08T07:33:29.107+0000 2024-10-08T07:33:29.107+0000 2022-11-24T18:59:08.929+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kuck, Karl-Heinz Catheter Ablation Versus Best Medical Therapy in Patients With Persistent Atrial Fibrillation and Congestive Heart Failure The Randomized AMICA Trial. true true /api/journal/10011405 REVIEWED true false 10011405 false 10011405 true 1941-3149 1941-3084 Journal FOREIGN 12 12 e007731 e007731 12 2019 Optimal treatment of patients with persistent atrial fibrillation (AF) and heart failure (HF) with reduced left ventricular ejection fraction (LVEF) and an indication for internal defibrillator therapy is controversial.Patients with persistent/longstanding persistent AF and LVEF ≤35% were randomly allocated to catheter ablation of AF or best medical therapy (BMT). The primary study end point was the absolute increase in LVEF from baseline at 1 year. Secondary end points included 6-minute walk test, quality-of-life, and NT-proBNP (N-terminal pro-brain natriuretic peptide). Pulmonary vein isolation was the primary ablation approach; BMT comprised rate or rhythm control. All patients were discharged after index hospitalization with a cardioverter-defibrillator or cardiac resynchronization therapy defibrillator implanted. The study was terminated early for futility.Of 140 patients (65±8 years, 126 [90%] men) available for the end point analysis, 68 and 72 patients were assigned to ablation and BMT, respectively. At 1 year, LVEF had increased in ablation patients by 8.8% (95% CI, 5.8%-11.9%) and in BMT patients by 7.3% (4.3%-10.3%; P=0.36). Sinus rhythm was recorded on 12-lead electrocardiograms at 1 year in 61/83 ablation patients (73.5%) and 42/84 BMT patients (50%). Device-recorded AF burden at 1 year was 0% or maximally 5% of the time in 28/39 ablation patients (72%) and 16/36 BMT patients (44%). There was no difference in secondary end point outcome between ablation patients and BMT patients.The AMICA trial (Atrial Fibrillation Management in Congestive Heart Failure With Ablation) did not reveal any benefit of catheter ablation in patients with AF and advanced HF. This was mainly because of the fact that at 1 year, LVEF increased in ablation patients to a similar extent as in BMT patients. The effect of catheter ablation of AF in patients with HF may be affected by the extent of HF at baseline, with a rather limited ablation benefit in patients with seriously advanced HF.URL: https://www.clinicaltrials.gov. 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Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 2 26 3 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88866952 /api/authorship/88866952 1 0.09090909 true false false Kuck Karl-Heinz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866953 /api/authorship/88866953 2 0.09090909 false false false Author 10002691 /api/author/10002691 Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866954 /api/authorship/88866954 3 0.09090909 false false false Zahn Ralf true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866955 /api/authorship/88866955 4 0.09090909 false false false Arentz Thomas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866956 /api/authorship/88866956 5 0.09090909 false false false Seidl Karlheinz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866957 /api/authorship/88866957 6 0.09090909 false false false Schlüter Michael true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866958 /api/authorship/88866958 7 0.09090909 false false false Tilz Roland Richard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866959 /api/authorship/88866959 8 0.09090909 false false false Piorkowski Christopher true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866960 /api/authorship/88866960 9 0.09090909 false false false Author 10013950 /api/author/10013950 Gellér László Alajos true 10013950 true Gellér László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866961 /api/authorship/88866961 10 0.09090909 false false false Kleemann Thomas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88866962 /api/authorship/88866962 11 0.09090909 false true false Hindricks Gerhard true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16143641 /api/publicationidentifier/16143641 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1161/CIRCEP.119.007731 https://doi.org/10.1161/CIRCEP.119.007731 false true PublicationIdentifier 16434818 /api/publicationidentifier/16434818 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000503199500008 https://www.webofscience.com/wos/woscc/full-record/000503199500008 false true PublicationIdentifier 19566577 /api/publicationidentifier/19566577 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85075497788 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85075497788 false true PublicationIdentifier 16143640 /api/publicationidentifier/16143640 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31760819 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31760819&dopt=Abstract false true Keyword 5924 /api/keyword/5924 true 5924 true Keyword 14018 /api/keyword/14018 true 14018 true Keyword 1011644 /api/keyword/1011644 true 1011644 true Keyword 1101336 /api/keyword/1101336 true 1101336 true Keyword 1555213 /api/keyword/1555213 true true SjrRating 10758789 /api/sjrrating/10758789 26 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true D1 DIRECT true true /api/publication/30935721 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Kuck Karl-Heinz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zahn Ralf </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Arentz Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Seidl Karlheinz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schlüter Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tilz Roland Richard </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Piorkowski Christopher </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013950"><a href="/gui2/?type=authors&mode=browse&sel=10013950" target="_blank">Gellér László (<span class="authorship-author-name">Gellér László Alajos</span> <span class="authorAux-mtmt"> Kardiológia, Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kleemann Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hindricks Gerhard </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30935721" target="_blank">Catheter Ablation Versus Best Medical Therapy in Patients With Persistent Atrial Fibrillation and Congestive Heart Failure : The Randomized AMICA Trial..</a></div> <div> <span class="journal-title">CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1941-3149">1941-3149</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1941-3084">1941-3084</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">12</span> <span class="page"> Paper e007731. 12 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1161/CIRCEP.119.007731" target="_blank" href="https://doi.org/10.1161/CIRCEP.119.007731"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000503199500008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000503199500008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85075497788" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85075497788"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31760819" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31760819&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 215</span> | Független: 197 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 192 | Scopus jelölt:&nbsp;205 | WoS/Scopus jelölt:&nbsp;215 | DOI jelölt:&nbsp;214 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30935721&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30935721</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2022.11.24. 19:59 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: St Jude Medical, Inc. Funding text: The AMICA trial (Atrial Fibrillation Management in Congestive Heart Failure With Ablation) was funded by St Jude Medical, Inc.</pre> </div></div>