https://m2.mtmt.hu/ hun 2026-09-21 02:37 JournalArticle 30924895 VALIDATED true Funding Agency and Grant Number: National Research, Development, and Innovation Office [NKFI-127961]; OTKA/NKFIHOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 128123, NK 115375, FIEK_16-1-2016-0005]; Hungarian Ministry for Innovation and Technology [UNKP-19-3-I-SE-15, UNKP-19-2-I-BME-380] Funding text: This research was funded by National Research, Development, and Innovation Office, grant number NKFI-127961, (T.H.) OTKA/NKFIH grant_K 128123 (L.H.), OTKA/NKFIH grant NK 115375 (B.S.) and FIEK_16-1-2016-0005 (B.S. and L.H.). Z.B. and O.M. were supported by grants UNKP-19-3-I-SE-15 (Z.B.) and UNKP-19-2-I-BME-380 (O.M.) from the Hungarian Ministry for Innovation and Technology. 0 false 2026-05-19T13:54:11.831+0000 2021-05-10T09:52:50.712+0000 2019-11-19T15:35:36.252+0000 true 10010446 Homolya László /api/author/10010446 Author true 10010446 2026-03-03T10:42:44.625+0000 2026-03-03T10:42:44.625+0000 2021-02-23T08:29:35.982+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 2021-05-10T09:52:50.724+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10003133 /api/admin/10003133 Boros Annamária true 10003133 true 2022-07-08T10:16:39.536+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Mózner, Orsolya Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism. true true /api/journal/10051562 REVIEWED true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 8 10 1215 1215 15 2019 The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells. Variants of the ABCG2 transporter, affecting cellular processing and trafficking, have been shown to cause gout and increased drug toxicity. In this paper, we overview the key cellular pathways involved in the processing and trafficking of large membrane proteins, focusing on ABC transporters. We discuss the information available for disease-causing polymorphic variants and selected mutations of ABCG2, causing increased degradation and impaired travelling of the transporter to the plasma membrane. In addition, we provide a detailed in silico analysis of an as yet unrecognized loop region of the ABCG2 protein, in which a recently discovered mutation may actually promote ABCG2 membrane expression. We suggest that post-translational modifications in this unstructured loop at the cytoplasmic surface of the protein may have special influence on ABCG2 processing and trafficking. true 2019 true true true false true false GOLD 2026-05-19 true https://doi.org/10.3390/cells8101215 26 0 26 20 3 26 26 25 21 26 26 20 20 20 6 0 26 20 26 20 0 18 18 Folyóiratcikk Journal Article 24 26 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 2 1 2 1 2021 0 6 2 6 2 2022 0 5 4 5 4 2023 0 5 5 5 5 2024 0 1 1 1 1 2025 0 5 5 5 5 2026 0 2 2 2 2 false 10073889,1241938 false false false 2019-12-06T07:45:43.390+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK); MTA-SE Molekuláris Biofizikai Kutatócsoport (SE / AOK / I / BSI) 6 35 3 6 0 true 10003133 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88804641 /api/authorship/88804641 1 0.16666667 true false false Author 10073889 /api/author/10073889 Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88804642 /api/authorship/88804642 2 0.16666667 false false false Author 10054127 /api/author/10054127 Bartos Zsuzsa true 10054127 true Bartos Zsuzsa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88804643 /api/authorship/88804643 3 0.16666667 false false false Author 10053932 /api/author/10053932 Zámbó Boglárka true 10053932 true Zámbó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88804644 /api/authorship/88804644 4 0.16666667 false false false Author 10010446 /api/author/10010446 Homolya László true 10010446 true Homolya László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88804645 /api/authorship/88804645 5 0.16666667 false false true Author 10015687 /api/author/10015687 Hegedűs Tamás true 10015687 true Hegedűs Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88804646 /api/authorship/88804646 6 0.16666667 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs true 1241938 true Sarkadi Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16122939 /api/publicationidentifier/16122939 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cells8101215 https://doi.org/10.3390/cells8101215 false true PublicationIdentifier 16122942 /api/publicationidentifier/16122942 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true GREEN true IDENTICAL 7967 https://repo.lib.semmelweis.hu/handle/123456789/7967 false true PublicationIdentifier 16122941 /api/publicationidentifier/16122941 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GOLD true 103410 http://real.mtak.hu/103410 false true PublicationIdentifier 16180012 /api/publicationidentifier/16180012 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000497336400104 https://www.webofscience.com/wos/woscc/full-record/000497336400104 false true PublicationIdentifier 18463498 /api/publicationidentifier/18463498 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85084933719 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85084933719 true true PublicationIdentifier 16122938 /api/publicationidentifier/16122938 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31597297 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31597297&dopt=Abstract false true Classification 10575 /api/classification/10575 true true Keyword 14169 /api/keyword/14169 true 14169 true Keyword 19906 /api/keyword/19906 true 19906 true Keyword 1058033 /api/keyword/1058033 true 1058033 true Keyword 1819865 /api/keyword/1819865 true true Keyword 1819866 /api/keyword/1819866 true true /api/publication/30924895 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Zsuzsa (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya László (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs Tamás ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biofizikai és Sugárbiológiai Intézet">BSI</span>/MTA-SE Molekuláris Biofizikai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30924895" target="_blank">Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism.</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">10</span> <span class="page"> Paper 1215. 15 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells8101215" target="_blank" href="https://doi.org/10.3390/cells8101215"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="7967" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/7967"> SE Repozitórium </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="103410" target="_blank" href="http://real.mtak.hu/103410"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000497336400104" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000497336400104"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85084933719" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85084933719"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31597297" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31597297&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 26</span> | Független: 20 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 25 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;26 | DOI jelölt:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30924895&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30924895</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2021.05.10. 11:52 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <div class="lockedBy">Központi kezelésű 2022.07.08. 12:16 Boros Annamária (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development, and Innovation Office [NKFI-127961]; OTKA/NKFIHOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K 128123, NK 115375, FIEK_16-1-2016-0005]; Hungarian Ministry for Innovation and Technology [UNKP-19-3-I-SE-15, UNKP-19-2-I-BME-380] Funding text: This research was funded by National Research, Development, and Innovation ...</pre> </div></div>