https://m2.mtmt.hu/ hun 2026-09-23 05:42 JournalArticle 30924863 VALIDATED true 0 false 2026-05-19T13:54:18.079+0000 2022-12-12T14:09:51.225+0000 2019-11-19T14:49:37.905+0000 true 10015745 Enyedi Ágnes /api/author/10015745 Author true 10015745 5385285 2026-02-02T10:30:38.612+0000 2026-02-02T10:30:38.911+0000 Author 10015745 /api/author/10015745 Enyedi Ágnes true 10015745 true SUSPECT 2025-03-20T20:04:30.661+0000 2026-02-02T10:30:38.857+0000 2021-02-17T10:33:02.688+0000 true 10020110 Farkas Andrea /api/admin/10020110 Admin true 10020110 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hegedűs, L. Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions true true /api/journal/15628 REVIEWED true false 15628 false 15628 true 0065-2598 2214-8019 Journal FOREIGN 1131 93 129 93 37 2020 Plasma membrane Ca2+ transport ATPases (PMCA1-4, ATP2B1-4) are responsible for removing excess Ca2+ from the cell in order to keep the cytosolic Ca2+ ion concentration at the low level essential for normal cell function. While these pumps take care of cellular Ca2+ homeostasis they also change the duration and amplitude of the Ca2+ signal and can create Ca2+ gradients across the cell. This is accomplished by generating more than twenty PMCA variants each having the character – fast or slow response, long or short memory, distinct interaction partners and localization signals – that meets the specific needs of the particular cell-type in which they are expressed. It has become apparent that these pumps are essential to normal tissue development and their malfunctioning can be linked to different pathological conditions such as certain types of neurodegenerative and heart diseases, hearing loss and cancer. In this chapter we summarize the complexity of PMCA regulation and function under normal and pathological conditions with particular attention to recent developments of the field. © Springer Nature Switzerland AG 2020. 2019 true true true false true false NONE 2026-05-19 false 22 0 22 20 3 22 22 21 16 22 22 20 20 20 2 0 22 20 22 20 0 30 30 Folyóiratcikk Journal Article 24 21 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 3 3 3 3 2021 0 6 5 6 5 2022 0 3 3 3 3 2023 0 0 0 0 0 2024 0 4 3 4 3 2025 0 4 4 4 4 2026 0 2 2 2 2 Q2 false 10015745,10029020,10015749 false false false 2020-02-17T15:09:15.010+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Enzimológiai Intézet (TTK); II. 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/api/reference/2552707 241 false true Reference 2552708 /api/reference/2552708 242 false true Reference 2552709 /api/reference/2552709 243 false true Reference 2552710 /api/reference/2552710 244 false true Reference 2552711 /api/reference/2552711 245 false true Reference 2552712 /api/reference/2552712 246 false true Reference 2552713 /api/reference/2552713 247 false true Reference 2552714 /api/reference/2552714 248 false true /api/publication/30924863 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hegedűs L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó B. (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015749"><a href="/gui2/?type=authors&mode=browse&sel=10015749" target="_blank">Pászty K. (<span class="authorship-author-name">Pászty Katalin</span> <span class="authorAux-mtmt"> Biokémia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029020"><a href="/gui2/?type=authors&mode=browse&sel=10029020" target="_blank">Padányi R. (<span class="authorship-author-name">Padányi Rita</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035825"><a href="/gui2/?type=authors&mode=browse&sel=10035825" target="_blank">Varga K. (<span class="authorship-author-name">Varga Karolina</span> <span class="authorAux-mtmt"> kémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Penniston J.T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015745"><a href="/gui2/?type=authors&mode=browse&sel=10015745" target="_blank">Enyedi Á. ✉ (<span class="authorship-author-name">Enyedi Ágnes</span> <span class="authorAux-mtmt"> Biokémia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/II. Sz. Patológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30924863" target="_blank">Molecular Diversity of Plasma Membrane Ca2+ Transporting ATPases: Their Function Under Normal and Pathological Conditions</a></div> <div> <span class="journal-title">ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0065-2598">0065-2598</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2214-8019">2214-8019</a>)</span>: <span class="journal-volume">1131</span> <span class="page"> pp 93-129 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/978-3-030-12457-1_5" target="_blank" href="https://doi.org/10.1007/978-3-030-12457-1_5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000539038900005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000539038900005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074100841" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074100841"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31646508" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31646508&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 20 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 21 | Scopus jelölt:&nbsp;16 | WoS/Scopus jelölt:&nbsp;22 | DOI jelölt:&nbsp;22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30924863&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 30 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30924863</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző Duplumgyanú | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="duplumMark">Duplumjelölés: </div> <div class="lastModified">Utolsó módosítás: 2022.12.12. 15:09 Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) </div> </div></div>