{ "labelLang" : "hun", "responseDate" : "2024-03-29 16:18", "content" : { "otype" : "JournalArticle", "mtid" : 30914066, "status" : "VALIDATED", "published" : true, "comment" : "Department of Public Health and Pediatric Sciences, University of Turin, Via Santena 9, Turin, 10126, Italy \n Otorhinolaryngology Division, Department of Surgical Sciences, University of Turin, Via Genova 3, Turin, 10126, Italy \n Department of Translational Medicine, University of Eastern Piedmont “A. Avogadro”, Via Solaroli 17, Novara, 28100, Italy \n Otorhinolaryngology Division, Department of Surgery, University of Eastern Piedmont “A. Avogadro”, Corso Mazzini 18, Novara, Italy \n Cited By :4 \n Export Date: 8 September 2020 \n CODEN: MLBRB \n Correspondence Address: Landolfo, S.; Department of Public Health and Pediatric Sciences, University of Turin, Via Santena 9, Italy; email: santo.landolfo@unito.it \n Chemicals/CAS: cytidine deaminase, 9025-06-3; AIM2 protein, human; APOBEC3 protein, human; Biomarkers, Tumor; Cytidine Deaminase; DNA, Viral; DNA-Binding Proteins; IFI16 protein, human; Nuclear Proteins; Phosphoproteins \n Funding details: Università degli Studi di Torino, UNITO, LANS_RILO_17_01, DELV_RILO_17_01 \n Funding details: 2015RMNSTA \n Funding text 1: Funding This work was supported by: Italian Ministry of Education, University and Research-MIUR (PRIN 2015 to VDO, 2015RMNSTA); Research Funding from the University of Turin (DELV_RILO_17_01, LANS_RILO_17_01, 2018, to SL and VDO). 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clinical characteristics, and survival. For this purpose, 34 HNSCC tissue specimens along with healthy surrounding mucosa were collected from patients surgically treated for HNSCC. Nucleic acids were isolated to assess the presence of HPV and the expression levels of selected molecular markers. Survival analysis was carried out using the Kaplan-Meier method. In HPV-negative (HPV-) HNSCCs, we detected low mRNA expression levels of IFI16, A3A, and A3B, whereas these genes were upregulated of 2-100 folds in HPV-positive (HPV+) tumors (p<0.05). Interestingly, AIM2 gene expression levels were predominantly unchanged in HPV+ HNSCCs compared to their HPV- counterparts, in which AIM2 was predominantly upregulated (10% vs. 50% of patients). In HPV- tumors, upregulation of TP53, NOTCH1, PD-L1, and IFI16 correlated with lower occurrence of nodal metastases. On the other hand, the expression of APOBEC family members did not correlate with clinical characteristics. Regarding survival, patients with upregulated A3F gene expression had a worse prognosis, while patients without changes in A3H expression had a lower survival rate. In conclusion, our findings indicate that the innate immune sensors IFI16 and AIM2 and some APOBEC family members could be potentially used as biomarkers for disease outcome in HNSCC patients regardless of HPV presence.", "subjects" : [ { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 1168, "link" : "/api/keyword/1168", "label" : "SURVIVAL", "published" : true, "oldId" : 1168, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1033294, "link" : "/api/keyword/1033294", "label" : "Head and neck cancer", "published" : true, "oldId" : 1033294, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1067310, "link" : "/api/keyword/1067310", "label" : "human papillomavirus", "published" : true, "oldId" : 1067310, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1817206, "link" : "/api/keyword/1817206", "label" : "PYHIN proteins", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1817207, "link" : "/api/keyword/1817207", "label" : "APOBEC proteins", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2021-11-18", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10994407, "link" : "/api/sjrrating/10994407", "label" : "sjr:Q2 (2019) Scopus - Medicine (miscellaneous) MOLECULAR BIOLOGY REPORTS 0301-4851 1573-4978", "listPos" : 1334, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2701, "link" : "/api/classificationexternal/2701", "label" : "Scopus - Medicine (miscellaneous)", "published" : true, "oldId" : 2701, "snippet" : true }, "ranking" : "Q2", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 14, "ownerInstituteCount" : 27, "directInstituteCount" : 0, "authorCount" : 8, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30914066", "label" : "Riva Giuseppe et al. 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