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Public Health, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, China; email: gaoyu_ciel@sjtu.edu.cn\nDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China \n School of Nursing, Shanghai Jiao Tong University School of Medicine, Shanghai, China \n MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China \n Department of Pediatrics, Shanghai East Hospital, Tongji University School of Medicine, China \n Department of Respiratory Medicine, Shanghai Children's Hospital Shanghai Jiao Tong University, Shanghai, China \n School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China \n Cited By :7 \n Export Date: 10 September 2020 \n CODEN: IJEHF \n Correspondence Address: Gao, Y.; Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University 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However, a limited number of studies are available for effects during children at a younger age, especially in China.Methods: Based on Laizhou Wan Birth Cohort (LWBC), BPA concentrations were measured in urine among 506 pregnant women during their hospital admission for delivery and neurodevelopment of their children was assessed using the Gesell Development Schedules at 12 months (n = 368) and 24 months (n = 296). Linear regression and generalized linear models were used to analyze the association between prenatal BPA exposure and the children's developmental quotient scores (DQs).Results: The median of maternal BPA concentration was 0.48 mu g/L or 1.05 mu g/g creatinine. Maternal BPA concentrations were adversely associated with children DQs at 12 months of age, with a 10-fold increase in prenatal BPA concentrations correlated to 1.43-point decrease in DQs in the adaptive domain (beta = -1.43; 95% CI: -2.30 to -0.56, p = 0.001). When stratified by gender, prenatal BPA concentrations were adversely associated with the adaptive domain DQs among boys (p-trend = 0.012) and girls (p-trend = 0.028) and the social domain DQs (p-trend = 0.019) only among girls. At 24 months of age, the significant adverse association was only found in the language domain among girls (beta = -1.69; 95% CI: -3.23 to -0.15, p = 0.032).Conclusion: Based on a Chinese population, we found potential impacts of prenatal BPA exposure on childhood neurodevelopment at 12 and 24 months of age, especially among girls.", "subjects" : [ { "otype" : "Classification", "mtid" : 12347, "link" : "/api/classification/12347", "label" : "Egészségtudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12347, "link" : "/api/classification/12347", "label" : "Egészségtudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 658, "link" : "/api/keyword/658", "label" : "CHILDREN", "published" : true, "oldId" : 658, "snippet" : true }, { "otype" : "Keyword", "mtid" : 9634, "link" : "/api/keyword/9634", "label" : "CHINA", "published" : true, "oldId" : 9634, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1008988, "link" : "/api/keyword/1008988", "label" : "Prenatal", "published" : true, "oldId" : 1008988, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1084282, "link" : "/api/keyword/1084282", "label" : "neurodevelopment", "published" : true, "oldId" : 1084282, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1486197, "link" : "/api/keyword/1486197", "label" : "Bisphenol A", "published" : true, "oldId" : 1486197, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2020-09-10", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10886382, "link" : "/api/sjrrating/10886382", "label" : "sjr:Q1 (2019) Scopus - Public Health, Environmental and Occupational Health INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 1438-4639 1618-131X", "listPos" : 62, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2739, "link" : "/api/classificationexternal/2739", "label" : "Scopus - Public Health, Environmental and Occupational Health", "published" : true, "oldId" : 2739, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 10, "ownerInstituteCount" : 33, "directInstituteCount" : 0, "authorCount" : 10, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30912525", "label" : "Pan Rui et al. 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