{ "labelLang" : "hun", "responseDate" : "2024-03-28 09:47", "content" : { "otype" : "JournalArticle", "mtid" : 30909627, "status" : "VALIDATED", "published" : true, "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2022-02-12T13:54:17.454+0000", "lastModified" : "2019-11-11T20:26:23.580+0000", "created" : "2019-11-12T04:38:34.327+0000", "creator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "lastDuplumOK" : "2022-01-03T21:31:27.533+0000", "lastDuplumSearch" : "2022-01-03T21:31:27.533+0000", "validated" : "2019-11-12T04:38:34.476+0000", "validator" : { "otype" : "Admin", "mtid" : 565, "link" : "/api/admin/565", "label" : "WoS import (admin)", "familyName" : "WoS", "givenName" : "import", "published" : true, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Grillone, Agostina", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 88721550, "link" : "/api/authorship/88721550", "label" : "Grillone, Agostina ✉", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : true, "familyName" : "Grillone", "givenName" : "Agostina", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721551, "link" : "/api/authorship/88721551", "label" : "Battaglini, Matteo ✉", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Battaglini", "givenName" : "Matteo", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721552, "link" : "/api/authorship/88721552", "label" : "Moscato, Stefania", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Moscato", "givenName" : "Stefania", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721553, "link" : "/api/authorship/88721553", "label" : "Mattii, Letizia", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Mattii", "givenName" : "Letizia", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721554, "link" : "/api/authorship/88721554", "label" : "Fernandez, Cesar de Julian", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Fernandez", "givenName" : "Cesar de Julian", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721555, "link" : "/api/authorship/88721555", "label" : "Scarpellini, Alice", "listPosition" : 6, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Scarpellini", "givenName" : "Alice", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721556, "link" : "/api/authorship/88721556", "label" : "Giorgi, Mario", "listPosition" : 7, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Giorgi", "givenName" : "Mario", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721557, "link" : "/api/authorship/88721557", "label" : "Sinibaldi, Edoardo ✉", "listPosition" : 8, "share" : 0.0, "first" : false, "last" : false, "corresponding" : true, "familyName" : "Sinibaldi", "givenName" : "Edoardo", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88721558, "link" : "/api/authorship/88721558", "label" : "Ciofani, Gianni ✉", "listPosition" : 9, "share" : 0.0, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Ciofani", "givenName" : "Gianni", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 16093801, "link" : "/api/publicationidentifier/16093801", "label" : "DOI: 10.2217/nnm-2018-0436", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "idValue" : "10.2217/nnm-2018-0436", "realUrl" : "https://doi.org/10.2217%2Fnnm-2018-0436", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16093800, "link" : "/api/publicationidentifier/16093800", "label" : "WoS: 000465611700006", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=@@@&DestApp=WOS", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "idValue" : "000465611700006", "realUrl" : "http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000465611700006&DestApp=WOS", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10007177, "link" : "/api/journal/10007177", "label" : "NANOMEDICINE 1743-5889 1748-6963", "pIssn" : "1743-5889", "eIssn" : "1748-6963", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10007177, "snippet" : true }, "volume" : "14", "issue" : "6", "firstPage" : "727", "lastPage" : "752", "firstPageOrInternalIdForSort" : "727", "pageLength" : 26, "publishedYear" : 2019, "abstractText" : "Aim: Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency. Materials & methods: Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells. Results: Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug. Conclusion: Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.[GRAPHICS]", "subjects" : [ { "otype" : "Classification", "mtid" : 11058, "link" : "/api/classification/11058", "label" : "Környezeti biotechnológia", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 11077, "link" : "/api/classification/11077", "label" : "Nanotechnológia", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 10193, "link" : "/api/keyword/10193", "label" : "Blood-Brain Barrier", "published" : true, "oldId" : 10193, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1055127, "link" : "/api/keyword/1055127", "label" : "glioblastoma multiforme", "published" : true, "oldId" : 1055127, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1208798, "link" : "/api/keyword/1208798", "label" : "SOLID LIPID NANOPARTICLES", "published" : true, "oldId" : 1208798, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1571998, "link" : "/api/keyword/1571998", "label" : "Nutlin-3a", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1575536, "link" : "/api/keyword/1575536", "label" : "Magnetic targeting", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1814793, "link" : "/api/keyword/1814793", "label" : "dynamic fluidic models", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-02-12", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10753722, "link" : "/api/sjrrating/10753722", "label" : "sjr:Q1 (2019) Scopus - Biomedical Engineering NANOMEDICINE 1743-5889 1748-6963", "listPos" : 56, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2204, "link" : "/api/classificationexternal/2204", "label" : "Scopus - Biomedical Engineering", "published" : true, "oldId" : 2204, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 7, "ownerInstituteCount" : 20, "directInstituteCount" : 0, "authorCount" : 9, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30909627", "label" : "Grillone Agostina et al. Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment. (2019) NANOMEDICINE 1743-5889 1748-6963 14 6 727-752", "template" : "