https://m2.mtmt.hu/hun2024-03-28 18:30JournalArticle30904446VALIDATEDtrue0false2021-08-30T22:43:14.352+00002019-11-11T16:54:58.423+00002019-11-11T18:27:37.693+0000true565WoSimport
/api/admin/565
Admintrue2019-11-11T18:27:37.295+00002019-11-11T18:27:37.295+00002019-11-11T18:27:37.837+0000true565WoSimport
/api/admin/565
Admintruefalsefalsetrue2424
/api/publicationtype/24
PublicationType1true24JournalArticletrue10000059Articletrue2424
/api/publicationtype/24
PublicationType1true24JournalArticle
/api/subtype/10000059
SzakcikkSubType101true10000059true1
/api/category/1
Categorytrue1McCue, Scott W.Hole-closing model reveals exponents for nonlinear degenerate diffusivity functions in cell biologytruetrue
/api/journal/3677
REVIEWEDtruefalse3677false3677true0167-2789JournalFOREIGN398130140130112019Continuum mathematical models for collective cell motion normally involve reaction-diffusion equations, such as the Fisher-KPP equation, with a linear diffusion term to describe cell motility and a logistic term to describe cell proliferation. While the Fisher-KPP equation and its generalisations are commonplace, a significant drawback for this family of models is that they are not able to capture the moving fronts that arise in cell invasion applications such as wound healing and tumour growth. An alternative, less common, approach is to include nonlinear degenerate diffusion in the models, such as in the Porous-Fisher equation, since solutions to the corresponding equations have compact support and therefore explicitly allow for moving fronts. We consider here a hole-closing problem for the Porous-Fisher equation whereby there is initially a simply connected region (the hole) with a nonzero population outside of the hole and a zero population inside. We outline how self-similar solutions (of the second kind) describe both circular and non-circular fronts in the hole-closing limit. Further, we present new experimental and theoretical evidence to support the use of nonlinear degenerate diffusion in models for collective cell motion. Our methodology involves setting up a two-dimensional wound healing assay that has the geometry of a hole-closing problem, with cells initially seeded outside of a hole that closes as cells migrate and proliferate. For a particular class of fibroblast cells, the aspect ratio of an initially rectangular wound increases in time, so the wound becomes longer and thinner as it closes; our theoretical analysis shows that this behaviour is consistent with nonlinear degenerate diffusion but is not able to be captured with commonly used linear diffusion. This work is important because it provides a clear test for degenerate diffusion over linear diffusion in cell lines, whereas standard one-dimensional experiments are unfortunately not capable of distinguishing between the two approaches. (C) 2019 Elsevier B.V. All rights reserved.2019truetruetruefalsefalseNONE2021-08-31false00000000000011Q1falsefalsefalsefalse111060trueLanguage10002
/api/language/10002
AngolEnglishtrue2truePersonAuthorship88664387
/api/authorship/88664387
10.0truefalsetrueMcCueScott W.truefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship88664388
/api/authorship/88664388
20.0falsefalsefalseJinWangtruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship88664389
/api/authorship/88664389
30.0falsefalsefalseMoroneyTimothy J.truefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship88664390
/api/authorship/88664390
40.0falsefalsefalseLoKai-YintruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship88664391
/api/authorship/88664391
50.0falsefalsefalseChouShih-EntruefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePersonAuthorship88664392
/api/authorship/88664392
60.0falsetruefalseSimpsonMatthew J.truefalsefalseAuthorshipType1
/api/authorshiptype/1
0true0truefalsetruePublicationIdentifier16083276
/api/publicationidentifier/16083276
10.1016/j.physd.2019.06.005https://doi.org/10.1016%2Fj.physd.2019.06.005falsetruePublicationIdentifier16083275
/api/publicationidentifier/16083275
000477786800008http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000477786800008&DestApp=WOSfalsetrueClassification10154
/api/classification/10154
truetrueClassification10003
/api/classification/10003
truetrueKeyword6131
/api/keyword/6131
true6131trueKeyword1283522
/api/keyword/1283522
true1283522trueKeyword1809958
/api/keyword/1809958
truetrueKeyword1809959
/api/keyword/1809959
truetrueKeyword1809960
/api/keyword/1809960
truetrueKeyword1809961
/api/keyword/1809961
truetrueSjrRating11001721
/api/sjrrating/11001721
820.24journalRatingType10002
/api/ratingtype/10002
sjrtruetrueClassificationExternal3104
/api/classificationexternal/3104
true3104trueQ1DIRECTtruetrue
/api/publication/30904446
<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > McCue, Scott W. ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Jin, Wang </span> <span class="author-type"> </span> ; <span class="author-name" > Moroney, Timothy J. </span> <span class="author-type"> </span> ; <span class="author-name" > Lo, Kai-Yin </span> <span class="author-type"> </span> ; <span class="author-name" > Chou, Shih-En </span> <span class="author-type"> </span> ; <span class="author-name" > Simpson, Matthew J. </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30904446" mtid="30904446" target="_blank">Hole-closing model reveals exponents for nonlinear degenerate diffusivity functions in cell biology</a></div> <div class="pub-info"> <span class="journal-title">PHYSICA D: NONLINEAR PHENOMENA</span> <span class="journal-volume">398</span> <span class="page"> pp. 130-140. , 11 p. </span> <span class="year">(2019)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1016/j.physd.2019.06.005" target="_blank" href="https://doi.org/10.1016%2Fj.physd.2019.06.005"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="000477786800008" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000477786800008&DestApp=WOS"> WoS </a> </span> </span> </div> <span class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30904446 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </span> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >McCue Scott W. ✉ </span> ; <span class="author-name" >Jin Wang </span> ; <span class="author-name" >Moroney Timothy J. </span> ; <span class="author-name" >Lo Kai-Yin </span> ; <span class="author-name" >Chou Shih-En </span> ; <span class="author-name" >Simpson Matthew J. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;30904446" target="_blank">Hole-closing model reveals exponents for nonlinear degenerate diffusivity functions in cell biology</a></div> <div> <span class="journal-title">PHYSICA D: NONLINEAR PHENOMENA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0167-2789">0167-2789</a> )</span>: <span class="journal-volume">398</span> <span class="page"> pp 130-140 </span> <span class="year">(2019)</span> <br> </span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1016/j.physd.2019.06.005" target="_blank" href="https://doi.org/10.1016%2Fj.physd.2019.06.005"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="000477786800008" target="_blank" href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=CustomerName&SrcApp=CustomerName&DestLinkType=FullRecord&KeyUT=000477786800008&DestApp=WOS"> WoS </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30904446&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30904446</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | Tudományos </span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2019.11.11. 17:54 WoS import (admin) </div> </div></div>