Role for Endocannabinoids in Spinal Manipulative Therapy Analgesia?

Onifer, Stephen M. ✉; Sozio, Randall S.; Long, Cynthia R.

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
  • SJR Scopus - Complementary and Alternative Medicine: Q1
    Chronic pain is quite prevalent and causes significant disabilities and socioeconomic burdens. Spinal manipulative therapy and other manipulative therapies are used to manage chronic pain. There is a critical knowledge gap about mechanisms and sites of action in spinal manipulative therapy pain relief, especially the short-term analgesia that occurs following a treatment. Endocannabinoids are an activity-dependent neurotransmitter system that acts as a short-term synaptic circuit breaker. This review describes both clinical research and basic research evidence suggesting that endocannabinoids contribute to short-term manipulative therapy analgesia. Determining endocannabinoids involvement in spinal manipulative therapy will improve its clinical efficacy when results from basic science and clinical research are translated.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2020-08-10 10:36