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Thereafter, immunohisto chemical approaches were utilized to determine parvalbumin (PV) and calbindin D-28K (CB) expression in the hippocampus following brain trauma in a time course. All hippocampal tissues were analyzed qualitatively and quantitatively using immunoreactivity, cell counting and densitometry. Statistical significance was determined by one-way ANOVA and Bonferroni's test.Results: At early time period following TBI, both PV and CB immunoreactivities decreased in the lesioned hippocampus. However, their expression levels were recovered to control levels as time passed by. On the other hand, PV immunoreactivity in contralateral hippocampus was transiently reduced whereas CB expression remained unchanged.Interpretation: Results of this study revealed that altered distribution of interneuronal populations in the hippocampus might contribute to neuronal loss induced by abnormality of inhibitory neurotransmission at early time period following brain damage, thus leading to the development of epileptogenesis in patients with TBI.", "subjects" : [ { "otype" : "Classification", "mtid" : 10399, "link" : "/api/classification/10399", "label" : "Föld- és kapcsolódó környezettudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 15329, "link" : "/api/keyword/15329", "label" : "traumatic brain injury", "published" : true, "oldId" : 15329, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1030818, "link" : "/api/keyword/1030818", "label" : "PARVALBUMIN", "published" : true, "oldId" : 1030818, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1046577, "link" : "/api/keyword/1046577", "label" : "epileptogenesis", "published" : true, "oldId" : 1046577, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1065886, "link" : "/api/keyword/1065886", "label" : "Calbindin D-28K", "published" : true, "oldId" : 1065886, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1503274, "link" : "/api/keyword/1503274", "label" : "Post-traumatic epilepsy", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : true, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2021-04-07", "oaFree" : false, "oaLink" : "http://www.jeb.co.in", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 8, "ownerInstituteCount" : 38, "directInstituteCount" : 0, "authorCount" : 6, "contributorCount" : 0, "hasQualityFactor" : false, "link" : "/api/publication/30893984", "label" : "Yu Y. 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