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Sgt. 40, Szeged, H-6724, Hungary \n Department of Biochemistry, University of Szeged, Dóm tér 9, Szeged, H-6720, Hungary \n Department of Pediatrics and Pediatric Health Center, University of Szeged, Korányi fasor 14-15, Szeged, H-6720, Hungary \n Department of Pharmacology and Pharmacotherapy, Semmelweis University, Nagyvárad tér 4, Budapest, H-1089, Hungary \n Cited By :10 \n Export Date: 2 March 2021 \n CODEN: NSAPC \n Correspondence Address: Jancsó, G.; Department of Physiology, Dóm tér 10, Hungary; email: gaborjancso@yahoo.co.uk \n Chemicals/CAS: allyl isothiocyanate, 57-06-7; calcitonin gene related peptide, 83652-28-2; capsaicin, 404-86-4; doxorubicin, 23214-92-8, 25316-40-9; n (4 isopropylphenyl) 2 (1,2,3,6 tetrahydro 1,3 dimethyl 2,6 dioxo 7h purin 7 yl)acetamide, 349085-38-7; vanilloid receptor 1, 363242-41-5; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; Antibiotics, Antineoplastic; Biomarkers; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Doxorubicin; mustard oil; Plant Oils; Trpa1 protein, rat; TRPC Cation Channels; TRPV Cation Channels; Trpv1 protein, rat \n Tradenames: hc 030031, Tocris, United Kingdom \n Manufacturers: Tocris, United Kingdom\nDepartment of Physiology, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary \n Department of Anatomy, University of Szeged, Kossuth L. 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"published" : true, "oldId" : 3297, "snippet" : true }, "volume" : "389", "issue" : "9", "firstPage" : "1009", "lastPage" : "1020", "firstPageOrInternalIdForSort" : "1009", "pageLength" : 12, "publishedYear" : 2016, "abstractText" : "Besides their deleterious action on cardiac muscle, anthracycline-type cytostatic agents exert significant neurotoxic effects on primary sensory neurons. Since cardiac sensory nerves confer protective effects on heart muscle and share common traits with cutaneous chemosensitive nerves, this study examined the effects of cardiotoxic doses of adriamycin on the function and morphology of epidermal nerves. Sensory neurogenic vasodilatation, plasma extravasation, and the neural CGRP release evoked by TRPV1 and TRPA1 agonists in vitro were examined by using laser Doppler flowmetry, the Evans blue technique, and ELISA, respectively. Carrageenan-induced hyperalgesia was assessed with the Hargreaves method. Immunohistochemistry was utilized to study cutaneous innervation. Adriamycin treatment resulted in profound reductions in the cutaneous neurogenic sensory vasodilatation and plasma extravasation evoked by the TRPV1 and TRPA1 agonists capsaicin and mustard oil, respectively. The in vitro capsaicin-, but not high potassium-evoked neural release of the major sensory neuropeptide, CGRP, was markedly attenuated after adriamycin treatment. Carrageenan-induced inflammatory hyperalgesia was largely abolished following the administration of adriamycin. Immunohistochemistry revealed a substantial loss of epidermal TRPV1-expressing nociceptive nerves and a marked thinning of the epidermis. These findings indicate impairments in the functions of TRPV1 and TRPA1 receptors expressed on cutaneous chemosensitive nociceptive nerves and the loss of epidermal axons following the administration of cardiotoxic doses of adriamycin. Monitoring of the cutaneous nociceptor function in the course of adriamycin therapy may well be of predictive value for early detection of the deterioration of cardiac nerves which confer protection against the deleterious effects of the drug.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12548, "link" : "/api/classification/12548", "label" : "Egyéb orvostudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12124, "link" : "/api/classification/12124", "label" : "Orvos- és egészségtudomány", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2016, "packet" : "545417", "foreignEdition" : 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