https://m2.mtmt.hu/ eng 2026-06-24 00:39 JournalArticle 30886434 VALIDATED true 0 false 2026-05-19T13:27:46.611+0000 2023-12-11T18:28:59.935+0000 2019-11-08T12:17:08.058+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-05-15T10:25:35.041+0000 2023-12-11T18:29:00.300+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2023-12-11T17:21:36.117+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Czigler, Andras Prostaglandin E2, a postulated mediator of neurovascular coupling, at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles true true /api/journal/25660 REVIEWED true false 25660 false 25660 true 1098-8823 2212-196X Journal FOREIGN 146 106389 106389 7 2020 There is considerable controversy regarding the vasoactive action of prostaglandin E2 (PGE2). On the one hand, indirect evidence implicates that astrocytic release of PGE2 contributes to neurovascular coupling responses mediating functional hyperemia in the brain. On the other hand, overproduction of PGE2 was also reported to contribute to cerebral vasospasm associated with subarachnoid hemorrhage. The present study was conducted to resolve this controversy by determining the direct vasoactive effects of PGE2 in resistance-sized human cerebral parenchymal arterioles. To achieve this goal PGE2-induced isotonic vasomotor responses were assessed in parenchymal arterioles isolated from fronto-temporo-parietal cortical tissues surgically removed from patients and expression of PGE2 receptors were examined. In functionally intact parenchymal arterioles lower concentrations of PGE2 (from 10-8 to 10-6 mol/l) caused significant, endothelium-independent vasorelaxation, which was inhibited by the EP4 receptor blocker BGC201531. In contrast, higher concentrations of PGE2 evoked significant EP1-dependent vasoconstriction, which could not be reversed by the EP4 receptor agonist CAY10598. We also confirmed previous observations that PGE2 primarily evokes constriction in intracerebral arterioles isolated from R. norvegicus. Importantly, vascular mRNA and protein expression of vasodilator EP4 receptors was significantly higher than that of vasoconstrictor EP1 receptors in human cerebral arterioles. PGE2 at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles. This bimodal vasomotor response is consistent with both the proposed vasodilator role of PGE2 during functional hyperemia and its putative role in cerebral vasospasm associated with subarachnoid hemorrhage in human patients. Funding 1983693 /api/funding/1983693 false true Funding 1983694 /api/funding/1983694 false true Funding 1983695 /api/funding/1983695 false true Funding 1983696 /api/funding/1983696 false true Funding 1983697 /api/funding/1983697 false true Funding 2013317 /api/funding/2013317 false true Funding 2013318 /api/funding/2013318 false true Funding 2013319 /api/funding/2013319 false true Funding 2013320 /api/funding/2013320 false true Funding 2013321 /api/funding/2013321 false true Funding 2013322 /api/funding/2013322 false true true 2019 true true true false true false RESTRICTED 2026-05-19 false 27 0 24 22 3 23 25 23 22 23 22 21 20 25 2 0 27 25 24 22 0 8 8 Folyóiratcikk Journal Article 24 24 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 2 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 1 1 1 2021 0 5 3 5 3 2022 0 5 5 5 5 2023 0 4 4 4 4 2024 0 3 3 3 3 2025 0 6 6 6 6 2026 0 3 3 3 3 Q2 false false false false 2019-12-29T13:47:32.002+0000 Idegsebészeti Klinika (PTE / ÁOK); Immunológiai és Biotechnológiai Intézet (PTE / ÁOK); Keringéskutató Laboratórium (PTE / SZKK); MTA-PTE Klinikai Idegtudományi Képalkotó Kutató... (PTE / KCS); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Neurotrauma kutatócsoport (PTE / SZKK); Orvosi Biológiai Intézet és Központi Elektronmi... (PTE / ÁOK); Szentágothai János Kutatóközpont (PTE); Transzlációs Medicina Intézet (PTE / ÁOK) 9 64 9 12 0 true 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88504726 /api/authorship/88504726 1 0.083333336 true false false Author 10062737 /api/author/10062737 Czigler András true 10062737 true Czigler Andras true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88504727 /api/authorship/88504727 2 0.083333336 false false false Author 10062680 /api/author/10062680 Tóth Luca true 10062680 true Toth Luca true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88504728 /api/authorship/88504728 3 0.083333336 false false false Author 10044514 /api/author/10044514 Szarka Nikolett true 10044514 true Szarka Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88503285 /api/authorship/88503285 4 0.083333336 false false false Szilágyi Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88504729 /api/authorship/88504729 5 0.083333336 false false false Author 10021059 /api/author/10021059 Kellermayer Zoltán true 10021059 true Kellermayer Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88504730 /api/authorship/88504730 6 0.083333336 false false false Author 10021151 /api/author/10021151 Stayer-Harci Alexandra true 10021151 true Harci Alexandra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88503288 /api/authorship/88503288 7 0.083333336 false false false Vecsernyes Monika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88504731 /api/authorship/88504731 8 0.083333336 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false 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1246653 /api/keyword/1246653 true 1246653 true Keyword 1565422 /api/keyword/1565422 true true Keyword 1574578 /api/keyword/1574578 true true Keyword 1575676 /api/keyword/1575676 true true SjrRating 10750978 /api/sjrrating/10750978 194 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q2 DIRECT true true /api/publication/30886434 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062737"><a href="/gui2/?type=authors&mode=browse&sel=10062737" target="_blank">Czigler Andras (<span class="authorship-author-name">Czigler András</span> <span class="authorAux-mtmt"> Általános orvos</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="University of Pécs">UP</span>/Szentágothai Research Centre; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062680"><a href="/gui2/?type=authors&mode=browse&sel=10062680" target="_blank">Toth Luca (<span class="authorship-author-name">Tóth Luca</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="University of Pécs">UP</span>/Szentágothai Research Centre; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044514"><a href="/gui2/?type=authors&mode=browse&sel=10044514" target="_blank">Szarka Nikolett (<span class="authorship-author-name">Szarka Nikolett</span> <span class="authorAux-mtmt"> Idegtudomány, agyi vérkeringés</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Neurotrauma Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szilágyi Krisztina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021059"><a href="/gui2/?type=authors&mode=browse&sel=10021059" target="_blank">Kellermayer Zoltan (<span class="authorship-author-name">Kellermayer Zoltán</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Immunology and Biotechnology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021151"><a href="/gui2/?type=authors&mode=browse&sel=10021151" target="_blank">Harci Alexandra (<span class="authorship-author-name">Stayer-Harci Alexandra</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Medical Biology and Central Electron Microscope Laboratory</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vecsernyes Monika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szolics Alex </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002221"><a href="/gui2/?type=authors&mode=browse&sel=10002221" target="_blank">Koller Akos (<span class="authorship-author-name">Koller Ákos</span> <span class="authorAux-mtmt"> Szív és vérkeringés</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="Semmelweis University">SU</span>/<span title="Faculty of Health Sciences">FHS</span>/Department of Morphology and Physiology; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Circulation Research Laboratory</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002667"><a href="/gui2/?type=authors&mode=browse&sel=10002667" target="_blank">Buki Andras (<span class="authorship-author-name">Büki András</span> <span class="authorAux-mtmt"> Idegsebészet, idegtudományok</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Neurotrauma Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021094"><a href="/gui2/?type=authors&mode=browse&sel=10021094" target="_blank">Toth Peter ✉ (<span class="authorship-author-name">Tóth Péter József</span> <span class="authorAux-mtmt"> Idegsebészet, cerebrovaszkuláris kórélettan</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Neurosurgery; <span title="University of Pécs">UP</span>/<span title="Research Groups">RG</span>/MTA-PTE Clinical Neuroscience MR Research Group; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Neurotrauma Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30886434" target="_blank">Prostaglandin E2, a postulated mediator of neurovascular coupling, at low concentrations dilates whereas at higher concentrations constricts human cerebral parenchymal arterioles</a></div> <div> <span class="journal-title">PROSTAGLANDINS & OTHER LIPID MEDIATORS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1098-8823">1098-8823</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2212-196X">2212-196X</a>)</span>: <span class="journal-volume">146</span> <span class="page"> Paper 106389. 7 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.prostaglandins.2019.106389" target="_blank" href="https://doi.org/10.1016/j.prostaglandins.2019.106389"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000510312800006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000510312800006"> WoS </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:black" title="173369" target="_blank" href="http://real.mtak.hu/173369"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85075539677" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85075539677"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31689497" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31689497&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Physiology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 27</span> | Independent citation: 25 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 23 | Number of citations in Scopus:&nbsp;22 | WoS/Scopus assigned:&nbsp;23 | Number of citations with DOI:&nbsp;25 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30886434&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30886434</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> A neuroinflammáció vizsgálata a neurodegenerativ folyamatokban: a molekulától a betegágyig(EFOP-3.6.2-16-2017-00008) Funder: EFOP, GINOP - STAY ALIVE(GINOP-2.3.2-15-2016-00048) Funder: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (2.3.3-15-2016-00032) Funder: GINOP, (20765-3/2018/3(FEKUTSTRAT)), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (NKFI-FK123798) Funder: OTKA-FK, (K108444), (BO/00634/15) Funder: MTA Bolyai pályázat, (PTE AOK-KA 3/2016 04.01/F), (ÚNKP-18–4-PTE-6), (GINOP-2.3.3-15-2016-00032) </div> <div class="lastModified">Last Modified: 2023.12.11. 19:28 Éva Pécsi (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Centrally managed 2023.12.11. 18:21 Éva Pécsi (MTMT Közp 2,3, admin) </div> </div></div>