https://m2.mtmt.hu/ hun 2026-09-20 23:30 JournalArticle 30886433 VALIDATED true 0 false 2026-07-30T12:06:16.374+0000 2023-12-11T18:42:47.632+0000 2019-11-08T12:17:06.364+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-07-30T08:45:08.075+0000 2023-12-11T18:42:48.160+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2023-12-11T17:21:36.117+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Fulop, Gabor A Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 41 5 575 589 575 15 2019 Cognitive impairment is one of the most common co-occurring chronic conditions among elderly heart failure patients (incidence: up to ~ 80%); however, the underlying mechanisms are not completely understood. It is hypothesized that in addition to decreased cardiac output, increases in central-and consequentially, cerebral-venous pressure (backward failure) also contribute significantly to the genesis of cognitive impairment. To test this hypothesis and elucidate the specific pathogenic role of venous congestion in the brain, we have established a novel model of increased cerebral venous pressure: mice with jugular vein ligation (JVL). To test the hypothesis that increased venous pressure in the brain contributes to the development of cognitive deficits by causing blood-brain barrier disruption, dysregulation of blood flow, and/or promoting neuroinflammation, in C57BL/6 mice, the internal and external jugular veins were ligated. Cognitive function (radial arm water maze), gait function (CatWalk), and motor coordination (rotarod) were tested post-JVL. Neurovascular coupling responses were assessed by measuring changes in cerebral blood flow in the whisker barrel cortex in response to contralateral whisker stimulation by laser speckle contrast imaging through a closed cranial window. Blood-brain barrier integrity (IgG extravasation) and microglia activation (Iba1 staining) were assessed in brain slices by immunohistochemistry. Neuroinflammation-related gene expression profile was assessed by a targeted qPCR array. After jugular vein ligation, mice exhibited impaired spatial learning and memory, altered motor coordination, and impaired gait function, mimicking important aspects of altered brain function observed in human heart failure patients. JVL did not alter neurovascular coupling responses. In the brains of mice with JVL, significant extravasation of IgG was detected, indicating blood-brain barrier disruption, which was associated with histological markers of neuroinflammation (increased presence of activated microglia) and a pro-inflammatory shift in gene expression profile. Thus, cerebral venous congestion per se can cause blood-brain barrier disruption and neuroinflammation, which likely contribute to the genesis of cognitive impairment. These findings have relevance to the pathogenesis of cognitive decline associated with heart failure as well as increased cerebal venous pressure due to increased jugular venous reflux in elderly human patients. 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Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 13 9 13 9 2021 0 11 7 11 7 2022 0 6 5 6 5 2023 0 11 10 11 10 2024 0 20 13 20 13 2025 0 13 13 13 13 2026 0 7 7 7 7 D1 false false false false 2019-12-01T16:20:24.670+0000 Biofizikai Intézet (HRN SZBK); Doktori Iskola (SE); Idegsebészeti Klinika (PTE / ÁOK); Klinikai Fiziológiai Tanszék (DE / ÁOK / KardI); Laki Kálmán Doktori Iskola (DE / ODT); Neurotrauma kutatócsoport (PTE / SZKK); Népegészségtani Intézet (SE / AOK / I); Orvosi Fizikai és Orvosi Informatikai Intézet (SZTE / SZAOK); Transzlációs Medicina Intézet (PTE / ÁOK); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 9 64 10 13 0 false 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88503269 /api/authorship/88503269 1 0.077 true false false Author 10044572 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/api/classification/10580 true true Classification 12227 /api/classification/12227 true true Classification 12235 /api/classification/12235 true true Classification 12124 /api/classification/12124 true true Classification 12211 /api/classification/12211 true true Keyword 1038254 /api/keyword/1038254 true 1038254 true Keyword 1061047 /api/keyword/1061047 true 1061047 true Keyword 1493411 /api/keyword/1493411 true true Keyword 1493413 /api/keyword/1493413 true true Keyword 1798035 /api/keyword/1798035 true true SjrRating 10767717 /api/sjrrating/10767717 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2707 /api/classificationexternal/2707 true 2707 true D1 DIRECT true true /api/publication/30886433 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10044572"><a href="/gui2/?type=authors&mode=browse&sel=10044572" target="_blank">Fulop Gabor A (<span class="authorship-author-name">Fülöp Gábor Áron</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Debreceni Egyetem">DE</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Laki Kálmán Doktori Iskola; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Klinikai Fiziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ahire Chetan<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csipo Tamas<sup>*</sup> (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Laki Kálmán Doktori Iskola; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Klinikai Fiziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano<sup>*</sup> (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss Tamas<sup>*</sup> (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Fizikai és Orvosi Informatikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balasubramanian Priya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy Andriy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Farkas Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003186"><a href="/gui2/?type=authors&mode=browse&sel=10003186" target="_blank">Toth Attila (<span class="authorship-author-name">Tóth Attila</span> <span class="authorAux-mtmt"> Szív és érrendszer, fájdalomkutatás</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Orvostudományi Doktori Tanács">ODT</span>/Laki Kálmán Doktori Iskola; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Klinikai Fiziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyúl-Tóth Ádám (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biofizikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021094"><a href="/gui2/?type=authors&mode=browse&sel=10021094" target="_blank">Toth Peter (<span class="authorship-author-name">Tóth Péter József</span> <span class="authorAux-mtmt"> Idegsebészet, cerebrovaszkuláris kórélettan</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Neurotrauma kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Fizikai és Orvosi Informatikai Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan ✉ (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Fizikai és Orvosi Informatikai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30886433" target="_blank">Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">41</span> <span class="journal-issue">5</span> <span class="page"> pp 575-589 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1007/s11357-019-00110-1" target="_blank" href="https://doi.org/10.1007/s11357-019-00110-1"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000494370900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000494370900001"> WoS </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:black" title="103598" target="_blank" href="https://real.mtak.hu/103598"> REAL </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="276441" target="_blank" href="http://hdl.handle.net/2437/276441"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074926339" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074926339"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31691147" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31691147&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 81</span> | Független: 64 | Függő: 17 | Nem jelölt: 0 | WoS jelölt: 76 | Scopus jelölt:&nbsp;74 | WoS/Scopus jelölt:&nbsp;80 | DOI jelölt:&nbsp;74 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30886433&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 29 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30886433</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (20765-3/2018/3(FEKUTSTRAT)), (2.3.3-15-2016-00032) Támogató: GINOP, GINOP - STAY ALIVE(GINOP-2.3.2-15-2016-00048) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, Intelligens élettudományi technológiák, módszertanok, alkalmazások fejlesztése és innovatív folya...(EFOP-3.6.1-16-2016-00008) Támogató: EFOP, A neuroinflammáció vizsgálata a neurodegenerativ folyamatokban: a molekulától a betegágyig(EFOP-3.6.2-16-2017-00008) Támogató: EFOP, (NKFI-FK123798) Támogató: OTKA-FK, (BO/00634/15) Támogató: MTA Bolyai pályázat, (ÚNKP-18–4-PTE-6) </div> <div class="lastModified">Utolsó módosítás: 2023.12.11. 19:42 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2023.12.11. 18:21 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>