https://m2.mtmt.hu/ hun 2026-10-24 13:52 JournalArticle 30879535 ADMIN_APPROVED true 0 false 2026-10-19T23:14:59.444+0000 2022-09-16T12:00:50.254+0000 2019-11-05T13:16:24.301+0000 true 10000492 Csiba László /api/author/10000492 Author Csiba László (Neurológia) true 10000492 2021-11-11T18:21:23.898+0000 2021-11-11T18:21:23.898+0000 2021-10-21T06:17:14.658+0000 true 10080085 Fölkerné Csernyik Rita /api/admin/10080085 Admin Fölkerné Csernyik Rita (MTMT ellenőrzés admin5) true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv (MTMT API user, admin) Ladányi Gusztáv true true Admin 10080085 /api/admin/10080085 Fölkerné Csernyik Rita (MTMT ellenőrzés admin5) Fölkerné Csernyik Rita true true 2021-10-23T01:09:39.567+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType Sokszerzős vagy csoportos szerzőségű szakcikk (Folyóiratcikk) 104 true 10000359 true 1 /api/category/1 Category Tudományos true 1 Khurana, Dheeraj true true /api/journal/10007440 REVIEWED PLOS ONE 1932-6203 true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 14 7 e0217472 e0217472 14 2019 BackgroundThe Ischemic Stroke System is a novel device designed to deliver stimulation to the sphenopalatine ganglion(SPG). The SPG sends parasympathetic innervations to the anterior cerebral circulation. In rat stroke models, SPG stimulation results in increased cerebral blood flow, reduced infarct volume, protects the blood brain barrier, and improved neurological outcome. We present here the results of a prospective, multinational, single-arm, feasibility study designed to assess the safety, tolerability, and potential benefit of SPG stimulation inpatients with acute ischemic stroke(AIS).MethodsPatients with anterior AIS, baseline NIHSS 7-20 and ability to initiate treatment within 24h from stroke onset, were implanted and treated with the SPG stimulation. Patients were followed up for 90 days. Effect was assessed by comparing the patient outcome to a matched population from the NINDS rt-PA trial placebo patients.ResultsNinety-eight patients were enrolled (mean age 57years, mean baseline NIHSS 12 and mean treatment time from stroke onset 19h). The observed mortality rate(12.2%), serious adverse events (SAE) incidence(23.5%) and nature of SAE were within the expected range for the population. The modified intention to treat cohort consisted of 84 patients who were compared to matched patients from the NINDS placebo arm. Patients treated with SPG stimulation had an average mRS lower by 0.76 than the historical controls(CMH test p = 0.001).ConclusionThe implantation procedure and the SPG stimulation, initiated within 24hr from stroke onset, are feasible, safe, and tolerable. 2019 true true true false true false GOLD 2026-10-20 true https://doi.org/10.1371/journal.pone.0217472 8 0 8 8 0 8 8 8 1 8 8 8 8 8 0 0 8 8 8 8 0 0 0 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2020 0 1 1 1 1 2021 0 1 1 1 1 2022 0 0 0 0 0 2023 0 0 0 0 0 2024 0 2 2 2 2 2025 0 1 1 1 1 2026 0 3 3 3 3 D1 A false false false false 2020-02-10T09:23:11.062+0000 Egészségtudományi Tanszék (SZE / ESK); MTA-DE Cerebrovascularis és Neurodegeneratív Ku... (DE / ÁOK); Neurológiai Tanszék (DE / ÁOK); Széchenyi István Egyetem 2 22 4 14 1 true 10080085 10067876 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 88452419 /api/authorship/88452419 Khurana, Dheeraj ✉ 1 0.071428575 true false true Khurana Dheeraj true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452420 /api/authorship/88452420 Kaul, Subhash 2 0.071428575 false false false Kaul Subhash true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452421 /api/authorship/88452421 Schneider, Dietmar 3 0.071428575 false false false Schneider Dietmar true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452422 /api/authorship/88452422 Csanyi, Attila [Csányi, Attila (Neurológia, strok...), szerző] Széchenyi István Egyetem; Egészségtudományi Tanszék (SZE / ESK) 4 0.071428575 false false false Author 10011385 /api/author/10011385 Csányi Attila (Neurológia, stroke, neurosonologia, elektrofiziológia) Csányi Attila true 10011385 true Csanyi Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452423 /api/authorship/88452423 Adam, Ilona 5 0.071428575 false false false Adam Ilona true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452424 /api/authorship/88452424 Ichaporia, Nasli R. 6 0.071428575 false false false Ichaporia Nasli R. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452425 /api/authorship/88452425 Griewing, Bernd 7 0.071428575 false false false Griewing Bernd true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88728842 /api/authorship/88728842 Csiba, Laszlo [Csiba, László (Neurológia), szerző] Neurológiai Tanszék (DE / ÁOK); MTA-DE Cerebrovascularis és Neurodegeneratív Ku... (DE / ÁOK) 8 0.071428575 false false false Author 10000492 /api/author/10000492 Csiba László (Neurológia) Csiba László true 10000492 true Csiba Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452427 /api/authorship/88452427 Valikovics, Attila 9 0.071428575 false false false Valikovics Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452428 /api/authorship/88452428 Puri, Vinod 10 0.071428575 false false false Puri Vinod true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452429 /api/authorship/88452429 Diener, Hans Christoph 11 0.071428575 false false false Diener Hans Christoph true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452430 /api/authorship/88452430 Schwab, Stefan 12 0.071428575 false false false Schwab Stefan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88452431 /api/authorship/88452431 Hetzel, Andreas 13 0.071428575 false false false Hetzel Andreas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 88728843 /api/authorship/88728843 Bornstein, Natan 14 0.071428575 false true false Bornstein Natan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 99140568 /api/authorship/99140568 ImpACT-Study, Grp [Kollaborációs szervezet] 15 0.0 false false ImpACT-Study Grp false false true AuthorshipType 30 /api/authorshiptype/30 Kollaborációs szervezet -29 true -29 true false true PublicationIdentifier 16031571 /api/publicationidentifier/16031571 DOI: 10.1371/journal.pone.0217472 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true 10.1371/journal.pone.0217472 https://doi.org/10.1371/journal.pone.0217472 false true PublicationIdentifier 16031570 /api/publicationidentifier/16031570 WoS: 000484927300005 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000484927300005 https://www.webofscience.com/wos/woscc/full-record/000484927300005 false true PublicationIdentifier 21688335 /api/publicationidentifier/21688335 Scopus: 85069268954 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85069268954 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85069268954 true true Classification 10799 /api/classification/10799 Egyéb természettudományok true true MtaRating 10486385 /api/mtarating/10486385 II. 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Powers, William J.: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association 2 false true Reference 2545966 /api/reference/2545966 3. Albers, G. W.: Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging 3 false true Reference 2545967 /api/reference/2545967 4. Nogueira, R. G.: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct 4 false true Reference 2545968 /api/reference/2545968 5. Guenego, Adrien: Hypoperfusion ratio predicts infarct growth during transfer for thrombectomy 5 false true Reference 2545969 /api/reference/2545969 6. Goyal, M.: Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke 6 false true Reference 2545970 /api/reference/2545970 7. Levi, Haviv: Stimulation of the Sphenopalatine Ganglion Induces Reperfusion and Blood-Brain Barrier Protection in the Photothrombotic Stroke Model 7 false true Reference 2545971 /api/reference/2545971 8. Shuaib, Ashfaq: Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target 8 false true Reference 2545972 /api/reference/2545972 9. Su Diansan: Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion 9 false true Reference 2545973 /api/reference/2545973 10. Bar-Shir, Amnon: Late Stimulation of the Sphenopalatine-Ganglion in Ischemic Rats: Improvement in N-Acetyl-Aspartate Levels and Diffusion Weighted Imaging Characteristics as Seen by MR 10 false true Reference 2545974 /api/reference/2545974 11. Khurana, D.: Implant for augmentation of cerebral blood flow trial 1: a pilot study evaluating the safety and effectiveness of the Ischaemic Stroke System for treatment of acute ischaemic stroke 11 false true Reference 2545975 /api/reference/2545975 12. Saver, Jeffrey L.: Treatment effects for which shift or binary analyses are advantageous in acute stroke trials 12 false true Reference 2545976 /api/reference/2545976 13. Henninger, Nils: Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke 13 false true Reference 2545977 /api/reference/2545977 14. Subramaniam, S: Massive cerebral infarction 14 false true Reference 2545978 /api/reference/2545978 15. Liebeskind, DS: Collateral circulation 15 false true Reference 2545979 /api/reference/2545979 16. Laska, AC: Aphasia in acute stroke and relation to outcome 16 false true Reference 2545980 /api/reference/2545980 17. Goldstein, LB: Reliability of the National Institutes of Health Stroke Scale - Extension to non-neurologists in the context of a clinical trial 17 false true Reference 2545981 /api/reference/2545981 18. MARLER, JR: TISSUE-PLASMINOGEN ACTIVATOR FOR ACUTE ISCHEMIC STROKE 18 false true Reference 2545982 /api/reference/2545982 19. BROTT, T: MEASUREMENTS OF ACUTE CEREBRAL INFARCTION - A CLINICAL EXAMINATION SCALE 19 false true Reference 2545983 /api/reference/2545983 20. GOLDSTEIN, LB: INTERRATER RELIABILITY OF THE NIH STROKE SCALE 20 false true Reference 2545984 /api/reference/2545984 21. SEYLAZ, J: EFFECT OF STIMULATION OF THE SPHENOPALATINE GANGLION ON CORTICAL BLOOD-FLOW IN THE RAT 21 false true /api/publication/30879535 Khurana Dheeraj et al. Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke. (2019) PLOS ONE 1932-6203 14 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Khurana Dheeraj ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kaul Subhash </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schneider Dietmar </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011385"><a href="/gui2/?type=authors&mode=browse&sel=10011385" target="_blank">Csanyi Attila (<span class="authorship-author-name">Csányi Attila</span> <span class="authorAux-mtmt"> Neurológia, stroke, neurosonologia, elektrofizi...</span>) </a> </span> <span class="author-affil">Széchenyi István Egyetem; <span title="Széchenyi István Egyetem">SZE</span>/<span title="Egészség- és Sporttudományi Kar">ESK</span>/Egészségtudományi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Adam Ilona </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ichaporia Nasli R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Griewing Bernd </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000492"><a href="/gui2/?type=authors&mode=browse&sel=10000492" target="_blank">Csiba Laszlo (<span class="authorship-author-name">Csiba László</span> <span class="authorAux-mtmt"> Neurológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Neurológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/MTA-DE Cerebrovascularis és Neurodegeneratív Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Valikovics Attila </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Puri Vinod </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Diener Hans Christoph </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwab Stefan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hetzel Andreas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bornstein Natan </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-name" >ImpACT-Study Grp </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30879535" target="_blank">Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">7</span> <span class="page"> Paper e0217472. 14 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="10.1371/journal.pone.0217472" target="_blank" href="https://doi.org/10.1371/journal.pone.0217472"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000484927300005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000484927300005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85069268954" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85069268954"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 8 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30879535</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2022.09.16. 14:00 Pappné Czappán Marianna (DE/TTK admin5) </div> <div class="lockedBy">Központi kezelésű 2021.10.23. 03:09 Ladányi Gusztáv (MTMT API user, admin) Fölkerné Csernyik Rita (MTMT ellenőrzés admin5) </div> </div></div>