{ "labelLang" : "hun", "responseDate" : "2024-03-28 16:54", "content" : { "otype" : "JournalArticle", "mtid" : 30872995, "status" : "VALIDATED", "published" : true, "comment" : "Funding Agency and Grant Number: Institut Pasteur; Universidad de las Americas; Programme Transversal de Recherche [PTR484]; TOTAL Foundation\n Funding text: This work was supported by the Institut Pasteur, the Universidad de las Americas, a \"Programme Transversal de Recherche PTR484\" grant, and a TOTAL Foundation grant (https://www.foundation.total/fr).\nOne Health Research Group, Faculty of Health Sciences, Universidad de las Américas, Quito, Pichincha, EC170125, Ecuador \n Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, 75015, France \n Institut Pasteur, Biology of Enteric Viruses Unit, Paris, 75015, France \n INSERM U994, Institut National de la Santé et de la Recherche Médicale, Paris, 75015, France \n Export Date: 13 February 2020 \n Correspondence Address: Muslin, C.; One Health Research Group, Faculty of Health Sciences, Universidad de las Américas, Quito, Ecuador; email: claire.muslin@udla.edu.ec\nCited By :12 \n Export Date: 19 May 2021", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-02-05T21:41:24.930+0000", "lastModified" : "2019-11-01T17:52:44.324+0000", "created" : "2019-11-01T20:04:30.658+0000", "creator" : { "otype" : "Admin", "mtid" : 10039043, "link" : "/api/admin/10039043", "label" : "Milánkovics Róbert (PTE ÁOK admin 4)", "familyName" : "Milánkovics", "givenName" : "Róbert", "published" : true, "oldId" : 10039043, "snippet" : true }, "lastDuplumSearch" : "2024-01-11T12:37:05.573+0000", "validated" : "2019-11-01T20:04:30.856+0000", "validator" : { "otype" : "Admin", "mtid" : 10039043, "link" : "/api/admin/10039043", "label" : "Milánkovics Róbert (PTE ÁOK admin 4)", "familyName" : "Milánkovics", "givenName" : "Róbert", "published" : true, "oldId" : 10039043, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 1134514, "link" : "/api/subtype/1134514", "label" : "Összefoglaló cikk (Folyóiratcikk)", "name" : "Összefoglaló cikk", "nameEng" : "Survey paper", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 102, "published" : true, "oldId" : 1134514, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Muslin, Claire", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 88407909, "link" : "/api/authorship/88407909", "label" : "Muslin, Claire ✉", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "corresponding" : true, "familyName" : "Muslin", "givenName" : "Claire", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88407910, "link" : "/api/authorship/88407910", "label" : "Mac Kain, Alice", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Mac Kain", "givenName" : "Alice", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88407911, "link" : "/api/authorship/88407911", "label" : "Bessaud, Mael", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Bessaud", "givenName" : "Mael", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88407912, "link" : "/api/authorship/88407912", "label" : "Blondel, Bruno", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : false, "corresponding" : false, "familyName" : "Blondel", "givenName" : "Bruno", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 88407913, "link" : "/api/authorship/88407913", "label" : "Delpeyroux, Francis", "listPosition" : 5, "share" : 0.0, "first" : false, "last" : true, "corresponding" : false, "familyName" : "Delpeyroux", "givenName" : "Francis", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "snippet" : true } ], "title" : "Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 16019710, "link" : "/api/publicationidentifier/16019710", "label" : "DOI: 10.3390/v11090859", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.3390/v11090859", "realUrl" : "https://doi.org/10.3390/v11090859", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16019709, "link" : "/api/publicationidentifier/16019709", "label" : "WoS: 000487962400001", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/WOS:@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "000487962400001", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/WOS:000487962400001", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16621729, "link" : "/api/publicationidentifier/16621729", "label" : "Scopus: 85072525030", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "85072525030", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85072525030", "published" : false, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16621663, "link" : "/api/publicationidentifier/16621663", "label" : "PubMed: 31540135", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "31540135", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31540135&dopt=Abstract", "published" : false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10015873, "link" : "/api/journal/10015873", "label" : "VIRUSES 1999-4915", "eIssn" : "1999-4915", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10015873, "snippet" : true }, "volume" : "11", "issue" : "9", "internalId" : "859", "firstPageOrInternalIdForSort" : "859", "pageLength" : 30, "publishedYear" : 2019, "abstractText" : "RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologous intertypic recombinant enteroviruses that were observed in nature would be the final products of a multi-step process, during which precursor nonhomologous recombinant genomes are generated through an initial inter-genomic RNA recombination event and can then evolve into a diversity of fitter homologous recombinant genomes over subsequent intra-genomic rearrangements. Moreover, these experimental studies demonstrated that the enterovirus genome could be defined as a combination of genomic modules that can be preferentially exchanged through recombination, and enabled defining the boundaries of these recombination modules. These results provided the first experimental evidence supporting the theoretical model of enterovirus modular evolution previously elaborated from phylogenetic studies of circulating enterovirus strains. This review summarizes our current knowledge regarding the mechanisms of recombination in enteroviruses and presents a new evolutionary process that may apply to other RNA viruses.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 2743, "link" : "/api/keyword/2743", "label" : "RECOMBINATION", "published" : true, "oldId" : 2743, "snippet" : true }, { "otype" : "Keyword", "mtid" : 12382, "link" : "/api/keyword/12382", "label" : "emergence", "published" : true, "oldId" : 12382, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1038793, "link" : "/api/keyword/1038793", "label" : "RNA virus", "published" : true, "oldId" : 1038793, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1204895, "link" : "/api/keyword/1204895", "label" : "Enterovirus", "published" : true, "oldId" : 1204895, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1499576, "link" : "/api/keyword/1499576", "label" : "Viral evolution", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2023-02-05", "oaFree" : false, "oaLink" : "http://www.mdpi.com/journal/viruses", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10823325, "link" : "/api/sjrrating/10823325", "label" : "sjr:Q1 (2019) Scopus - Infectious Diseases VIRUSES 1999-4915", "listPos" : 42, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2725, "link" : "/api/classificationexternal/2725", "label" : "Scopus - Infectious Diseases", "published" : true, "oldId" : 2725, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "directInstitutesForSort" : "", "ownerAuthorCount" : 3, "ownerInstituteCount" : 11, "directInstituteCount" : 0, "authorCount" : 5, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30872995", "label" : "Muslin Claire et al. Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process. (2019) VIRUSES 1999-4915 11 9", "template" : "