https://m2.mtmt.hu/ hun 2026-05-31 15:42 JournalArticle 30869113 VALIDATED true * Megosztott szerzőség 0 false 2026-05-19T12:55:25.658+0000 2023-09-02T15:29:48.879+0000 2019-10-30T13:26:14.495+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-07-31T08:40:25.305+0000 2023-09-02T15:29:49.171+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Kaune, Tom Common variants in glyoxalase I do not increase chronic pancreatitis risk true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 14 10 e0222927 e0222927 14 2019 Chronic pancreatitis (CP) may be caused by oxidative stress. An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE). Methylglyoxal is detoxified by Glyoxalase I (GLO1). A reduction in GLO1 activity results in increased ROS. Single nucleotide polymorphisms (SNPs) of GLO1 have been linked to various inflammatory diseases. Here, we analyzed whether common GLO1 variants are associated with alcoholic (ACP) and non-alcoholic CP (NACP).Using melting curve analysis, we genotyped a screening cohort of 223 ACP, 218 NACP patients, and 328 controls for 11 tagging SNPs defined by the SNPinfo LD TAG SNP Selection tool and the functionally relevant variant rs4746. For selected variants the cohorts were extended to up to 1,441 patient samples.In the ACP cohort, comparison of genotypes for rs1937780 between patients and controls displayed an ambiguous result in the screening cohort (p = 0.08). However, in the extended cohort of 1,441 patients no statistically significant association was found for the comparison of genotypes (p = 0.11), nor in logistic regression analysis (p = 0.214, OR 1.072, 95% CI 0.961-1.196). In the NACP screening cohort SNPs rs937662, rs1699012, and rs4746 displayed an ambiguous result when patients were compared to controls in the recessive or dominant model (p = 0.08, 0.08, and 0.07, respectively). Again, these associations were not confirmed in the extended cohorts (rs937662, dominant model: p = 0.07, logistic regression: p = 0.07, OR 1.207, 95% CI 0.985-1.480) or in the replication cohorts for rs4746 (Germany, p = 0.42, OR 1.080, 95% CI 0.673-1.124; France, p = 0.19, OR 0.90, 95% CI 0.76-1.06; China, p = 0.24, OR 1.18, 95% CI 0.90-1.54) and rs1699012 (Germany, Munich; p = 0.279, OR 0.903, 95% CI 0.750-1.087).Common GLO1 variants do not increase chronic pancreatitis risk. 2019 true true true false true false GOLD 2026-05-19 true https://doi.org/10.1371/journal.pone.0222927 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 D1 A false false false false 2019-10-29T14:10:00.217+0000 I. sz. Belgyógyászati Klinika (PTE / ÁOK); MTA-SZTE Lendület Gasztroenterológiai Multidisz... (SZTE / SZAOK / BK / I.BelK); Transzlációs Medicina Intézet (PTE / ÁOK) 1 27 3 33 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88388840 /api/authorship/88388840 1 0.0 true false false Kaune Tom true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388841 /api/authorship/88388841 2 0.0 true false false Hollenbach Marcus true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388842 /api/authorship/88388842 3 0.0 false false false Keil Bettina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388843 /api/authorship/88388843 4 0.0 false false false Chen Jian-Min true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388844 /api/authorship/88388844 5 0.0 false false false Masson Emmanuelle true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388845 /api/authorship/88388845 6 0.0 false false false Becker Carla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388846 /api/authorship/88388846 7 0.0 false false false Damm Marko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388847 /api/authorship/88388847 8 0.0 false false false Ruffert Claudia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388848 /api/authorship/88388848 9 0.0 false false false Grützmann Robert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388849 /api/authorship/88388849 10 0.0 false false false Hoffmeister Albrecht true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388850 /api/authorship/88388850 11 0.0 false false false Te Morsche Rene H M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388851 /api/authorship/88388851 12 0.0 false false false Cavestro Giulia Martina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388852 /api/authorship/88388852 13 0.0 false false false Zuppardo Raffaella Alessia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388853 /api/authorship/88388853 14 0.0 false false false Saftoiu Adrian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388854 /api/authorship/88388854 15 0.0 false false false Malecka-Panas Ewa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388855 /api/authorship/88388855 16 0.0 false false false Głuszek Stanislaw true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388856 /api/authorship/88388856 17 0.0 false false false Bugert Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388857 /api/authorship/88388857 18 0.0 false false false Lerch Markus M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388858 /api/authorship/88388858 19 0.0 false false false Weiss Frank Ulrich true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388859 /api/authorship/88388859 20 0.0 false false false Zou Wen-Bin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388860 /api/authorship/88388860 21 0.0 false false false Liao Zhuan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88389351 /api/authorship/88389351 22 0.0 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388862 /api/authorship/88388862 23 0.0 false false false Drenth Joost Ph true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388863 /api/authorship/88388863 24 0.0 false false false Riedel Jan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388864 /api/authorship/88388864 25 0.0 false false false Férec Claude true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388865 /api/authorship/88388865 26 0.0 false false false Scholz Markus true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388866 /api/authorship/88388866 27 0.0 false false false Kirsten Holger true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388867 /api/authorship/88388867 28 0.0 false false false Tóth Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388868 /api/authorship/88388868 29 0.0 false false false Ewers Maren true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388869 /api/authorship/88388869 30 0.0 false false false Witt Heiko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388870 /api/authorship/88388870 31 0.0 false false false Griesmann Heidi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388871 /api/authorship/88388871 32 0.0 false false false Michl Patrick true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 88388872 /api/authorship/88388872 33 0.0 false true true Rosendahl Jonas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16012736 /api/publicationidentifier/16012736 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0222927 https://doi.org/10.1371/journal.pone.0222927 false true PublicationIdentifier 16947257 /api/publicationidentifier/16947257 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000532653400005 https://www.webofscience.com/wos/woscc/full-record/000532653400005 false true PublicationIdentifier 16071743 /api/publicationidentifier/16071743 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85074280588 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10023 /api/ratingtype/10023 PedTB Institute 14107 /api/institute/14107 0 false true false Pedagógiai Tudományos Bizottság Pedagógiai Tudományos Bizottság true 14107 true true true A true true MtaRating 519076 /api/mtarating/519076 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19076 true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 10859094 /api/sjrrating/10859094 10 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/30869113 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Kaune Tom </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Peter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="I. sz. Belgyógyászati Klinika">I.BelK</span>/MTA-SZTE Lendület Gasztroenterológiai Multidiszciplináris Kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; et al. (33) </div> <div><a target="_blank" href="/api/publication/30869113?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30869113" target="_blank">Common variants in glyoxalase I do not increase chronic pancreatitis risk</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">10</span> <span class="page"> Paper e0222927. 14 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0222927" target="_blank" href="https://doi.org/10.1371/journal.pone.0222927"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000532653400005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000532653400005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074280588" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074280588"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31661534" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31661534&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22007" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22007"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30869113&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30869113</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.02. 17:29 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>