{ "labelLang" : "hun", "responseDate" : "2024-03-28 20:29", "content" : { "otype" : "JournalArticle", "mtid" : 30854183, "status" : "APPROVED", "published" : true, "comment" : "Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul,Avcilar, 34320, Turkey \n Department of Microbiology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul,Avcilar, 34320, Turkey \n Department of Biology, Faculty of Education, Sivas Cumhuriyet University, Sivas, 58140, Turkey \n Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Yenimahalle-Ankara, 06330, Turkey \n Cited By :2 \n Export Date: 13 February 2020 \n CODEN: MOLEF \n Correspondence Address: Anlas, C.; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University-CerrahpasaTurkey; email: cerenis@istanbul.edu.tr\nDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul,Avcilar, 34320, Turkey \n Department of Microbiology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul,Avcilar, 34320, Turkey \n Department of Biology, Faculty of Education, Sivas Cumhuriyet University, Sivas, 58140, Turkey \n Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Yenimahalle-Ankara, 06330, Turkey \n Cited By :5 \n Export Date: 29 October 2020 \n CODEN: MOLEF \n Correspondence Address: Anlas, C.; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Istanbul University-CerrahpasaTurkey; email: cerenis@istanbul.edu.tr", "unhandledTickets" : 0, "deleted" : false, "lastRefresh" : "2023-02-16T08:16:08.677+0000", "lastModified" : "2019-10-21T06:36:02.690+0000", "created" : "2019-10-20T05:24:23.113+0000", "creator" : { "otype" : "Author", "mtid" : 10001420, "link" : "/api/author/10001420", "label" : "Felinger Attila (Analitikai kémia)", "familyName" : "Felinger", "givenName" : "Attila", "published" : true, 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Despite the widespread traditional use of TS, there is not any scientific report confirming the effectiveness of this plant on the healing process. This research aimed to investigate the effects of different extracts obtained from TS on biological events during wound healing, on a cellular basis. In this context, proliferative activities of the extracts, as well as the effects on wound closure and hydroxyproline synthesis, were determined. In addition to wound healing properties, the antioxidant, antibacterial and anti-inflammatory activities of the extracts were evaluated. Decoction (D) and infusion (I) extracts contained the highest amount of phenolic content and showed the most potent activity against DPPH radical. All extracts exhibited complete protection against the damage induced by hydrogen peroxide (H2O2) by increasing cell viability compared to only H2O2-treated groups, both in co-treatment and pre-treatment protocols. None of the extracts exhibited cytotoxic activity, and most of the extracts from the TS stimulated fibroblast proliferation and migration. All TS extracts exert anti-inflammatory activity by suppressing the overproduction of tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO). The most pronounced activity on hydroxyproline synthesis was observed in D extract. In summary, it was observed that TS extracts can promote the healing process by enhancing fibroblast migration, proliferation and collagen synthesis as well as suppressing pro-inflammatory cytokines. The obtained data in this work support the traditional use of TS as a valuable plant-based compound for the treatment of wounds.", "subjects" : [ { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10293, "link" : "/api/classification/10293", "label" : "Kémiai tudományok", "published" : true, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 2694, "link" : "/api/keyword/2694", "label" : "ANTIBACTERIAL", "published" : true, "oldId" : 2694, "snippet" : true }, { "otype" : "Keyword", "mtid" : 4826, "link" : "/api/keyword/4826", "label" : "ANTIOXIDANT", "published" : true, "oldId" : 4826, "snippet" : true }, { "otype" : "Keyword", "mtid" : 6131, "link" : "/api/keyword/6131", "label" : "Wound healing", "published" : true, "oldId" : 6131, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1019316, "link" : "/api/keyword/1019316", "label" : "anti-inflammatory", "published" : true, "oldId" : 1019316, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1786754, "link" : "/api/keyword/1786754", "label" : "Thymus sipyleus Boiss", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1786755, "link" : "/api/keyword/1786755", "label" : "subsp", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1786756, "link" : "/api/keyword/1786756", "label" : "rosulans (Borbas) Jalas", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2023-02-16", "oaFree" : false, "oaLink" : "http://www.mdpi.com/journal/molecules", "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 1, "citedCount" : 1, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10872180, "link" : "/api/sjrrating/10872180", "label" : "sjr:Q1 (2019) Scopus - Pharmaceutical Science MOLECULES 1420-3049 1420-3049", "listPos" : 44, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3003, "link" : "/api/classificationexternal/3003", "label" : "Scopus - Pharmaceutical Science", "published" : true, "oldId" : 3003, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2020-01-19T07:36:02.421+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 7, "ownerInstituteCount" : 47, "directInstituteCount" : 0, "authorCount" : 9, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/30854183", "label" : "Ustuner Oya et al. 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