https://m2.mtmt.hu/ eng 2026-05-31 12:02 JournalArticle 30850756 VALIDATED true 0 false 2026-05-27T15:08:56.005+0000 2024-11-25T13:36:34.940+0000 2019-10-17T12:39:47.564+0000 true 10056781 Bikádi Katalin /api/admin/10056781 Admin true 10056781 2025-03-22T18:41:53.269+0000 2025-03-22T18:41:53.269+0000 2024-11-25T13:36:35.145+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:42:14.442+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Otsu, Y Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula. true true /api/journal/4028 REVIEWED true false 4028 false 4028 true 0036-8075 1095-9203 Journal FOREIGN 366 6462 250 254 250 5 2019 The unconventional N-methyl-d-aspartate (NMDA) receptor subunits GluN3A and GluN3B can, when associated with the other glycine-binding subunit GluN1, generate excitatory conductances purely activated by glycine. However, functional GluN1/GluN3 receptors have not been identified in native adult tissues. We discovered that GluN1/GluN3A receptors are operational in neurons of the mouse adult medial habenula (MHb), an epithalamic area controlling aversive physiological states. In the absence of glycinergic neuronal specializations in the MHb, glial cells tuned neuronal activity via GluN1/GluN3A receptors. Reducing GluN1/GluN3A receptor levels in the MHb prevented place-aversion conditioning. Our study extends the physiological and behavioral implications of glycine by demonstrating its control of negatively valued emotional associations via excitatory glycinergic NMDA receptors. 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<span class="author-name" >Darcq E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pietrajtis K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="163"><a href="/gui2/?type=authors&mode=browse&sel=163" target="_blank">Matyas F (<span class="authorship-author-name">Mátyás Ferenc</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/<span title="Institute of Cognitive Neuroscience and Psychology">KPI</span>/MTA-TTK-NAP B Neuronal Network and Behaviour Research Group; <span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Alaptudományi Intézet">ATI</span>/Department of Anatomy and Histology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schwartz E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bessaih T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Abi Gerges S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rousseau C V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grand T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dieudonne S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Paoletti P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009548"><a href="/gui2/?type=authors&mode=browse&sel=10009548" target="_blank">Acsady L (<span class="authorship-author-name">Acsády László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Thalamus Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Agulhon C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kieffer B L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Diana M A </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30850756" target="_blank">Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula.</a></div> <div> <span class="journal-title">SCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0036-8075">0036-8075</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1095-9203">1095-9203</a>)</span>: <span class="journal-volume">366</span> <span class="journal-issue">6462</span> <span class="page"> pp 250-254 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1126/science.aax1522" target="_blank" href="https://doi.org/10.1126/science.aax1522"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000490014700046" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000490014700046"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="115674" target="_blank" href="http://real.mtak.hu/115674"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85073108027" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85073108027"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="31601771" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31601771&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - History and Philosophy of Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 82</span> | Independent citation: 72 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 81 | Number of citations in Scopus:&nbsp;69 | WoS/Scopus assigned:&nbsp;82 | Number of citations with DOI:&nbsp;82 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30850756&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30850756</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WoS (savedrecs (57).txt, 2019-10-17)</span> </div> <div class="funder"> Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002) </div> <div class="lastModified">Last Modified: 2024.11.25. 14:36 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:42 György Wolf (MTMT Központi admin) Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>