https://m2.mtmt.hu/ eng 2026-05-31 16:23 JournalArticle 30842041 VALIDATED true Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary Pathobiochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University (MTA-SE), Budapest, Hungary B&B Analytics Ltd., Érd, Hungary Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Hungary Export Date: 06 August 2025; Cited By: 5; Correspondence Address: V. Zámbó; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary; email: zambo.veronika@med.semmelweis-univ.hu; CODEN: FEBLA 0 false 2026-05-19T12:11:49.464+0000 2023-05-16T11:09:17.987+0000 2019-10-10T14:36:44.475+0000 true 10000786 Csala Miklós /api/author/10000786 Author true 10000786 2026-02-19T15:59:03.190+0000 2023-05-16T11:09:18.226+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Zámbó, Veronika Investigation of the putative rate-limiting role of electron transfer in fatty acid desaturation using transfected HEK293T cells true true /api/journal/1571 REVIEWED true false 1571 false 1571 true 0014-5793 1873-3468 Journal FOREIGN 594 3 530 539 530 10 2020 Elevated fatty acid (FA) levels contribute to severe metabolic diseases. Unbalanced oversupply of saturated FAs is particularly damaging, which renders stearoyl-CoA desaturase (SCD1) activity an important factor of resistance. A SCD1-related oxidoreductase protects cells against palmitate toxicity, so we aimed to test whether desaturase activity is limited by SCD1 itself or by the associated electron supply. Unsaturated/saturated FA ratio was markedly elevated by SCD1 overexpression while it remained unaffected by the overexpression of SCD1-related electron transfer proteins in HEK293T cells. Electron supply was not rate-limiting either in palmitate-treated cells or in cells with enhanced SCD1 expression. Our findings indicate the rate-limiting role of SCD1 itself, and that FA desaturation cannot be facilitated by reinforcing the electron supply of the enzyme. 2019 true true true false true false NONE 2026-05-19 false 7 0 6 2 5 5 6 4 5 5 5 2 2 2 5 0 7 2 6 2 0 4 4 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2021 0 1 0 1 0 2022 0 2 0 2 0 2023 0 0 0 0 0 2024 0 3 1 3 1 2025 0 1 1 1 1 D1 false 10052722,10020321,10025630,10024706,10065133 false false false 2019-11-01T13:51:47.892+0000 MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT); Orvosi Vegytani, Molekuláris Biológiai és Patob... 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31557308&dopt=Abstract true true Keyword 4978 /api/keyword/4978 true 4978 true Keyword 1030136 /api/keyword/1030136 true 1030136 true Keyword 1154518 /api/keyword/1154518 true 1154518 true Keyword 1754182 /api/keyword/1754182 true true SjrRating 10754272 /api/sjrrating/10754272 13 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1304 /api/classificationexternal/1304 true 1304 true D1 DIRECT true true /api/publication/30842041 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10025630"><a href="/gui2/?type=authors&mode=browse&sel=10025630" target="_blank">Zámbó Veronika ✉ (<span class="authorship-author-name">Zámbó Veronika</span> <span class="authorAux-mtmt"> Molekuláris biológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052995"><a href="/gui2/?type=authors&mode=browse&sel=10052995" target="_blank">Simon-Szabó Laura (<span class="authorship-author-name">Simon-Szabó Laura</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/<span title="Molekuláris Biológiai Tanszék">MBT</span>/MTA-SE Patobiokémiai Kutatócsoport (2006-ig: MTA-SE Peptid-Biokémiai Kutatócsoport); <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052722"><a href="/gui2/?type=authors&mode=browse&sel=10052722" target="_blank">Sarnyai Farkas (<span class="authorship-author-name">Sarnyai Farkas</span> <span class="authorAux-mtmt"> Molekuláris biológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065133"><a href="/gui2/?type=authors&mode=browse&sel=10065133" target="_blank">Mátyási Judit (<span class="authorship-author-name">Mátyási Judit</span> <span class="authorAux-mtmt"> kémiai tudományok</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Chemical Technology and Biotechnology">FCTB</span>/Department of Inorganic and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gór-Nagy Zsófia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057497"><a href="/gui2/?type=authors&mode=browse&sel=10057497" target="_blank">Somogyi Anna (<span class="authorship-author-name">Somogyi Anna</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032149"><a href="/gui2/?type=authors&mode=browse&sel=10032149" target="_blank">Szelényi Péter (<span class="authorship-author-name">Szelényi Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020321"><a href="/gui2/?type=authors&mode=browse&sel=10020321" target="_blank">Kereszturi Éva (<span class="authorship-author-name">Kereszturi Éva</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024706"><a href="/gui2/?type=authors&mode=browse&sel=10024706" target="_blank">Tóth Blanka ✉ (<span class="authorship-author-name">Tóth Blanka</span> <span class="authorAux-mtmt"> analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Chemical Technology and Biotechnology">FCTB</span>/Department of Inorganic and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000786"><a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala Miklós (<span class="authorship-author-name">Csala Miklós</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Medical Chemistry, Molecular Biology and Pathobiochemistry</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30842041" target="_blank">Investigation of the putative rate-limiting role of electron transfer in fatty acid desaturation using transfected HEK293T cells</a></div> <div> <span class="journal-title">FEBS LETTERS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0014-5793">0014-5793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-3468">1873-3468</a>)</span>: <span class="journal-volume">594</span> <span class="journal-issue">3</span> <span class="page"> pp 530-539 </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1002/1873-3468.13622" target="_blank" href="https://doi.org/10.1002/1873-3468.13622"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000489168100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000489168100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074591574" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074591574"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31557308" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31557308&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biophysics&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Genetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Structural Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 2 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 4 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;5 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30842041&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30842041</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS - Other (pericles_18733468AxA.ris, 2019-10-10)</span> </div> <div class="lastModified">Last Modified: 2023.05.16. 13:09 Anna Berhidi (SE_KK_Admin5_BA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary Pathobiochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University (MTA-SE), Budapest, Hungary B&B Analytics Ltd., Érd, Hungary Department of Inorganic and Analytical Chemistry, Budapest Uni...</pre> </div></div>