{ "labelLang" : "hun", "responseDate" : "2024-03-28 10:21", "content" : { "otype" : "JournalArticle", "mtid" : 30841665, "status" : "VALIDATED", "published" : true, "comment" : "Export Date: 10 October 2019 \n CODEN: FRBME \n Correspondence Address: Hwang, T.-L.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259 Wenhwa 1st Road, Kweishan, Taiwan; email: htl@mail.cgu.edu.tw \n Funding details: 107-2320-B-182A-003 \n Funding details: Ministry of Education, MOE, EMRPD1I0501, EMRPD1I0441 \n Funding details: Ministry of Science and Technology, Taiwan, MOST \n Funding details: 106-2320-B-255-003-MY3 \n Funding details: 108-2320-B-255-003-MY3 \n Funding details: Chang Gung Memorial Hospital, CGMH, BMRP450, CMRPG3J1001~3, CMRPG3G1201 \n Funding details: 107-2320-B-182A-008-MY3 \n Funding details: 106-2320-B-182A-002-MY2 \n Funding text 1: Funding: This work was supported by the grants from the Ministry of Science Technology ( MOST 107-2320-B-182A-008-MY3 , MOST 106-2320-B-255-003-MY3 , MOST 108-2320-B-255-003-MY3 , MOST 106-2320-B-182A-002-MY2 , and MOST 107-2320-B-182A-003 ), Ministry of Education ( EMRPD1I0501 and EMRPD1I0441 ), and Chang Gung Memorial Hospital ( CMRPG3J1001~3 , CMRPF1J0051~3 , CMRPF1G0241~3 , BMRP450 , and CMRPG3G1201 ), Taiwan. Appendix A\nExport Date: 5 December 2019 \n CODEN: FRBME \n Correspondence Address: Hwang, T.-L.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259 Wenhwa 1st Road, Kweishan, Taiwan; email: htl@mail.cgu.edu.tw \n Chemicals/CAS: Bruton tyrosine kinase, 149147-12-6; protein tyrosine kinase, 80449-02-1; resveratrol, 501-36-0; Vav protein, 282122-55-8 \n Funding details: 107-2320-B-182A-003 \n Funding details: Ministry of Education, MOE, EMRPD1I0501, EMRPD1I0441 \n Funding details: Ministry of Science and Technology, Taiwan, MOST \n Funding details: 106-2320-B-255-003-MY3 \n Funding details: 108-2320-B-255-003-MY3 \n Funding details: Chang Gung Memorial Hospital, CGMH, BMRP450, CMRPG3J1001~3, CMRPG3G1201 \n Funding details: 107-2320-B-182A-008-MY3 \n Funding details: 106-2320-B-182A-002-MY2 \n Funding text 1: Funding: This work was supported by the grants from the Ministry of Science Technology ( MOST 107-2320-B-182A-008-MY3 , MOST 106-2320-B-255-003-MY3 , MOST 108-2320-B-255-003-MY3 , MOST 106-2320-B-182A-002-MY2 , and MOST 107-2320-B-182A-003 ), Ministry of Education ( EMRPD1I0501 and EMRPD1I0441 ), and Chang Gung Memorial Hospital ( CMRPG3J1001~3 , CMRPF1J0051~3 , CMRPF1G0241~3 , BMRP450 , and CMRPG3G1201 ), Taiwan. Appendix A\nExport Date: 18 December 2019 \n CODEN: FRBME \n Correspondence Address: Hwang, T.-L.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259 Wenhwa 1st Road, Kweishan, Taiwan; email: htl@mail.cgu.edu.tw \n Chemicals/CAS: Bruton tyrosine kinase, 149147-12-6; protein tyrosine kinase, 80449-02-1; resveratrol, 501-36-0; Vav protein, 282122-55-8 \n Funding details: 107-2320-B-182A-003 \n Funding details: Ministry of Education, MOE, EMRPD1I0501, EMRPD1I0441 \n Funding details: Ministry of Science and Technology, Taiwan, MOST \n Funding details: 106-2320-B-255-003-MY3 \n Funding details: 108-2320-B-255-003-MY3 \n Funding details: Chang Gung Memorial Hospital, CGMH, BMRP450, CMRPG3J1001~3, CMRPG3G1201 \n Funding details: 107-2320-B-182A-008-MY3 \n Funding details: 106-2320-B-182A-002-MY2 \n Funding text 1: Funding: This work was supported by the grants from the Ministry of Science Technology ( MOST 107-2320-B-182A-008-MY3 , MOST 106-2320-B-255-003-MY3 , MOST 108-2320-B-255-003-MY3 , MOST 106-2320-B-182A-002-MY2 , and MOST 107-2320-B-182A-003 ), Ministry of Education ( EMRPD1I0501 and EMRPD1I0441 ), and Chang Gung Memorial Hospital ( CMRPG3J1001~3 , CMRPF1J0051~3 , CMRPF1G0241~3 , BMRP450 , and CMRPG3G1201 ), Taiwan. Appendix A\nExport Date: 4 February 2020 \n CODEN: FRBME \n Correspondence Address: Hwang, T.-L.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259 Wenhwa 1st Road, Kweishan, Taiwan; email: htl@mail.cgu.edu.tw \n Chemicals/CAS: Bruton tyrosine kinase, 149147-12-6; protein tyrosine kinase, 80449-02-1; resveratrol, 501-36-0; Vav protein, 282122-55-8 \n Funding details: 107-2320-B-182A-003 \n Funding details: Ministry of Education, MOE, EMRPD1I0501, EMRPD1I0441 \n Funding details: Ministry of Science and Technology, Taiwan, MOST \n Funding details: 106-2320-B-255-003-MY3 \n Funding details: 108-2320-B-255-003-MY3 \n Funding details: Chang Gung Memorial Hospital, CGMH, BMRP450, CMRPG3J1001~3, CMRPG3G1201 \n Funding details: 107-2320-B-182A-008-MY3 \n Funding details: 106-2320-B-182A-002-MY2 \n Funding text 1: Funding: This work was supported by the grants from the Ministry of Science Technology ( MOST 107-2320-B-182A-008-MY3 , MOST 106-2320-B-255-003-MY3 , MOST 108-2320-B-255-003-MY3 , MOST 106-2320-B-182A-002-MY2 , and MOST 107-2320-B-182A-003 ), Ministry of Education ( EMRPD1I0501 and EMRPD1I0441 ), and Chang Gung Memorial Hospital ( CMRPG3J1001~3 , CMRPF1J0051~3 , CMRPF1G0241~3 , BMRP450 , and CMRPG3G1201 ), Taiwan. Appendix A\nCited By :1 \n Export Date: 12 May 2020 \n CODEN: FRBME \n Correspondence Address: Hwang, T.-L.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259 Wenhwa 1st Road, Kweishan, Taiwan; email: htl@mail.cgu.edu.tw \n Chemicals/CAS: Bruton tyrosine kinase, 149147-12-6; protein tyrosine kinase, 80449-02-1; resveratrol, 501-36-0; Vav protein, 282122-55-8 \n Funding details: EMRPD1I0501, EMRPD1I0441 \n Funding details: 106-2320-B-255-003-MY3, 108-2320-B-255-003-MY3, 107-2320-B-182A-008-MY3, MOST 107-2320-B-182A-003, 106-2320-B-182A-002-MY2 \n Funding details: Chang Gung Memorial Hospital, CGMH, BMRP450, CMRPG3J1001~3, CMRPF1J0051~3, CMRPF1G0241~3, CMRPG3G1201 \n Funding text 1: Funding: This work was supported by the grants from the Ministry of Science Technology ( MOST 107-2320-B-182A-008-MY3 , MOST 106-2320-B-255-003-MY3 , MOST 108-2320-B-255-003-MY3 , MOST 106-2320-B-182A-002-MY2 , and MOST 107-2320-B-182A-003 ), Ministry of Education ( EMRPD1I0501 and EMRPD1I0441 ), and Chang Gung Memorial Hospital ( CMRPG3J1001~3 , CMRPF1J0051~3 , CMRPF1G0241~3 , BMRP450 , and CMRPG3G1201 ), Taiwan.\nCited By :1 \n Export Date: 26 June 2020 \n CODEN: FRBME \n Correspondence Address: Hwang, T.-L.; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, 259 Wenhwa 1st Road, Kweishan, Taiwan; email: htl@mail.cgu.edu.tw \n Chemicals/CAS: Bruton tyrosine kinase, 149147-12-6; protein tyrosine kinase, 80449-02-1; resveratrol, 501-36-0; Vav protein, 282122-55-8 \n Funding details: EMRPD1I0501, EMRPD1I0441 \n Funding details: 106-2320-B-255-003-MY3, 108-2320-B-255-003-MY3, 107-2320-B-182A-008-MY3, MOST 107-2320-B-182A-003, 106-2320-B-182A-002-MY2 \n Funding details: Chang Gung Memorial Hospital, CGMH, BMRP450, CMRPG3J1001~3, CMRPF1J0051~3, CMRPF1G0241~3, CMRPG3G1201 \n Funding text 1: Funding: This work was supported by the grants from the Ministry of Science Technology ( MOST 107-2320-B-182A-008-MY3 , MOST 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}, "volume" : "145", "firstPage" : "67", "lastPage" : "77", "firstPageOrInternalIdForSort" : "67", "pageLength" : 11, "publishedYear" : 2019, "abstractText" : "The natural stilbenoid, Resveratrol (RSV; 3,5,4′-trihydroxystilbene) has been shown to have beneficial effects on inflammatory diseases as well as cancer, neurodegenerative diseases, and cardiovascular disorders. The underlying mechanism by which RSV affects neutrophil activation has yet to be fully elucidated. In this study, we tested the hypothesis that RSV modulates the inflammatory activities of formyl-Met-Leu-Phe-stimulated human neutrophils. We employed a well-established isolated-neutrophil model to investigate the effects of RSV on neutrophil functions and the underlying mechanism of signaling transduction. The lipopolysaccharide-induced ALI murine model was employed to evaluate the therapeutic effects of RSV. Experiment results demonstrate that RSV reduces respiratory burst, degranulation, integrin expression, and cell adhesion in activated neutrophils in dose-dependent manners. RSV inhibited phosphorylation of Src family kinases (SFKs) and reduced their enzymatic activities. Moreover, RSV and a selective inhibitor of SFKs (PP2) reduced the phosphorylation of Bruton's tyrosine kinase and Vav. There results indicated that the inhibitory effects of RSV are mediated through the inhibition of the SFKs-Btk-Vav pathway. This study also revealed that RSV attenuates endotoxin-induced lung injury. We surmise that the therapeutic effects of RSV on ALI may derive from its anti-neutrophilic inflammation function and free radical-scavenging effects. © 2019 Elsevier Inc.", "keywords" : [ { "otype" : "Keyword", "mtid" : 4581, "link" : "/api/keyword/4581", "label" : "neutrophil", "published" : true, "oldId" : 4581, "snippet" : true }, { "otype" : "Keyword", "mtid" : 8285, "link" : "/api/keyword/8285", "label" : "SUPEROXIDE ANION", "published" : true, "oldId" : 8285, "snippet" : true }, { "otype" : "Keyword", "mtid" : 15242, "link" : "/api/keyword/15242", "label" : "Reactive oxygen species", "published" : true, "oldId" : 15242, "snippet" : true }, { "otype" : "Keyword", "mtid" : 18943, "link" : "/api/keyword/18943", "label" : "LUNG INJURY", "published" : true, "oldId" : 18943, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1001049, "link" : "/api/keyword/1001049", "label" : "RESVERATROL", "published" : true, "oldId" : 1001049, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1720285, "link" : "/api/keyword/1720285", "label" : "Src family kinase", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2022-02-12", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 2, "citedCount" : 2, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10750566, "link" : "/api/sjrrating/10750566", "label" : "sjr:Q1 (2019) Scopus - Biochemistry FREE RADICAL BIOLOGY AND MEDICINE 0891-5849 1873-4596", "listPos" : 63, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1303, "link" : "/api/classificationexternal/1303", "label" : "Scopus - Biochemistry", "published" : true, "oldId" : 1303, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q1", "referenceList" : "Dvorakova, M., Landa, P., Anti-inflammatory activity of natural stilbenoids: a review (2017) Pharmacol. 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Ther., 332 (3), pp. 829-839 ;\n Martin, A.R., Villegas, I., La Casa, C., de la Lastra, C.A., Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats (2004) Biochem. Pharmacol., 67 (7), pp. 1399-1410 ;\n Sanchez-Fidalgo, S., Cardeno, A., Villegas, I., Talero, E., de la Lastra, C.A., Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice (2010) Eur. J. Pharmacol., 633 (1-3), pp. 78-84 ;\n Martin, A.R., Villegas, I., Sanchez-Hidalgo, M., de la Lastra, C.A., The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model (2006) Br. J. Pharmacol., 147 (8), pp. 873-885 ;\n Wang, K.T., Chen, L.G., Tseng, S.H., Huang, J.S., Hsieh, M.S., Wang, C.C., Anti-inflammatory effects of resveratrol and oligostilbenes from Vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis (2011) J. Agric. 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