https://m2.mtmt.hu/ hun 2026-09-22 12:43 JournalArticle 30828891 VALIDATED true BHF Cardiovascular Research Centre, University of Glasgow, 126 University Pl., Glasgow, G128TA, United Kingdom Cardiovascular Division, TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, United States Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States Rigshospitalet Copenhagen University Hospital, Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark Department of Medicine, Saarland University Hospital, Homburg-Saar, Germany Saint Luke's Mid America Heart Institute, University of Missouri, Kansas City, United States National University of Cordoba, Cordoba, Spain Division of Cardiology, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina Wroclaw Medical University, Wroclaw, Poland Department of Cardiology, Medical University of Lodz, Lodz, Poland Department of Cardiology, University of Minnesota, Minneapolis, United States 2nd Department of Internal Medicine, Department of Cardiovascular Medicine, General Teaching Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic Division of Cardiology, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan Department of Cardiology, Medanta, Gurgaon, India Department of Cardiology, University Medical Center, University of Groningen, Groningen, Netherlands 5th Department of Internal Medicine, Comenius University in Bratislava, Bratislava, Slovakia Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada Department of Cardiology, Montreal Heart Institute, Montreal, Canada Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria Cardiovascular Division of Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan Department of Molecular and Clinical Medicine and Cardiology, Sahlgrenska Academy, AstraZeneca, Gothenburg, Sweden Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden Heart and Vascular Center, Semmelweis University, Budapest, Hungary Instituto Do Coracao, Hospital das Clinicas, Faculdade de Medicina, Universidade de Saõ Paolo, Saõ Paolo, Brazil Department of Internal Medicine, Tan Tao University, Tan Duc, Viet Nam Department of Myocardial Disease and Heart Failure, National Medical Research Center of Cardiology, Moscow, Russian Federation Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, United States Division of Cardiac Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada Cited By :1420 Export Date: 6 October 2021 CODEN: NEJMA Correspondence Address: McMurray, J.J.V.; BHF Cardiovascular Research Centre, 126 University Pl., United Kingdom; email: john.mcmurray@glasgow.ac.uk Chemicals/CAS: dapagliflozin, 461432-26-8; digitalis, 8031-42-3, 8053-83-6; sacubitril plus valsartan, 936623-90-4; glucoside, 50986-29-3; glycosylated hemoglobin, 9062-63-9; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol; Benzhydryl Compounds; Cardiovascular Agents; Glucosides; Glycated Hemoglobin A; Sodium-Glucose Transporter 2 Inhibitors 0 false 2026-09-18T12:55:44.802+0000 2022-11-24T18:58:45.448+0000 2019-10-03T07:21:25.155+0000 true 10055096 Nagy Regina /api/admin/10055096 Admin true 10055096 2023-10-05T13:55:36.253+0000 2023-10-05T13:55:36.253+0000 2022-11-24T18:58:46.454+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 McMurray, John J V Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 381 21 1995 2008 1995 14 2019 In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the presence or absence of type 2 diabetes.In this phase 3, placebo-controlled trial, we randomly assigned 4744 patients with New York Heart Association class II, III, or IV heart failure and an ejection fraction of 40% or less to receive either dapagliflozin (at a dose of 10 mg once daily) or placebo, in addition to recommended therapy. The primary outcome was a composite of worsening heart failure (hospitalization or an urgent visit resulting in intravenous therapy for heart failure) or cardiovascular death.Over a median of 18.2 months, the primary outcome occurred in 386 of 2373 patients (16.3%) in the dapagliflozin group and in 502 of 2371 patients (21.2%) in the placebo group (hazard ratio, 0.74; 95% confidence interval [CI], 0.65 to 0.85; P<0.001). A first worsening heart failure event occurred in 237 patients (10.0%) in the dapagliflozin group and in 326 patients (13.7%) in the placebo group (hazard ratio, 0.70; 95% CI, 0.59 to 0.83). Death from cardiovascular causes occurred in 227 patients (9.6%) in the dapagliflozin group and in 273 patients (11.5%) in the placebo group (hazard ratio, 0.82; 95% CI, 0.69 to 0.98); 276 patients (11.6%) and 329 patients (13.9%), respectively, died from any cause (hazard ratio, 0.83; 95% CI, 0.71 to 0.97). Findings in patients with diabetes were similar to those in patients without diabetes. The frequency of adverse events related to volume depletion, renal dysfunction, and hypoglycemia did not differ between treatment groups.Among patients with heart failure and a reduced ejection fraction, the risk of worsening heart failure or death from cardiovascular causes was lower among those who received dapagliflozin than among those who received placebo, regardless of the presence or absence of diabetes. 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31535829&dopt=Abstract false true SjrRating 10990189 /api/sjrrating/10990189 4 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/30828891 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >McMurray John J V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span 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(38) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10033861"><a href="/gui2/?type=authors&mode=browse&sel=10033861" target="_blank">Masszi Gabriella (<span class="authorship-author-name">Masszi Gabriella</span> <span class="authorAux-mtmt"> Belgyógyászat, kardiológia</span>) </a> </span> <span class="author-affil">Nyírő Gyula Országos Pszichiátriai és Addiktológiai Intézet</span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">DAPA-HF Trial Committees and Investigators</span> </div> <div><a target="_blank" href="/api/publication/30828891?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30828891" target="_blank">Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">381</span> <span class="journal-issue">21</span> <span class="page"> pp 1995-2008 </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa1911303" target="_blank" href="https://doi.org/10.1056/NEJMoa1911303"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000505218800004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000505218800004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85073118508" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85073118508"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31535829" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31535829&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5,867</span> | Független: 5,315 | Függő: 552 | Nem jelölt: 0 | WoS jelölt: 5,390 | Scopus jelölt:&nbsp;5,499 | WoS/Scopus jelölt:&nbsp;5,866 | DOI jelölt:&nbsp;5,722 (Nem nyilvános:&nbsp;67) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30828891&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30828891</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed (pubmed_result.xml, 2019-10-03)</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/30828891/notduplums">1 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2022.11.24. 19:58 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: BHF Cardiovascular Research Centre, University of Glasgow, 126 University Pl., Glasgow, G128TA, United Kingdom Cardiovascular Division, TIMI Study Group, Brigham and Women's Hospital, Harvard Medical School, Boston, United States Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States Rigs...</pre> </div></div>